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2921“…One of the most common functions of circular RNA is to regulate microRNA expression by acting as a microRNA sponge. However, the circular RNA expression profile and function remain mostly unclear in gastric cancer. …”
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2922
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2923por Huang, Zhen, Liu, Fen, Wang, Wenjuan, Ouyang, Shaobo, Sang, Ting, Huang, Zikun, Liao, Lan, Wu, Jun“…The presence of miR-1231, miR-31 and miR-647 all obviously inhibited the expression of circ_003912, which was validated to sponge the expression of above miRNAs. Also, FOXP3 mRNA was proved to be targeted by miR-1231, miR-31 and miR-647. …”
Publicado 2021
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2924por Al-Khalaf, Areej A., Hassan, Hossam M., Alrajhi, Aisha M, Mohamed, Rania Ali El Hadi, Hozzein, Wael N.“…Purpose: To investigate the anti-cancer and anti-inflammatory potential of the Red Sea sponges, in their bulk and silver nanostructure. Metabolomics analysis of the selected sponge followed by molecular docking studies, will be conducted to explore and predict the secondary metabolites that might provide its capability of inhibiting cancer. …”
Publicado 2021
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2925por Wang, Yi, Ding, Minghong, Yuan, Xiaoqing, Jiao, Ruibao, Zhu, Dagao, Huang, Wanzhong, Deng, Wenxia, Liu, Yulong“…Mechanistically, SNHG15 promotes proliferation through upregulated CDK6 via sponging miR-370-3p. Taken together, our findings emphasize the important role of SNHG15 in ovarian cancer, suggesting that SNHG15 may be a promising target for ovarian cancer.…”
Publicado 2021
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2926“…CONCLUSIONS: DLEU1 is overexpressed in POF and sponges miR-146b-5p to increase KGN cell apoptosis.…”
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2927“…CONCLUSION: LncRNA STXBP5-AS1 is upregulated by Rh2 via promoter hypomethylation and acts as a ceRNA, sponging the oncogenic miR-4425. Therefore, Rh2 controls the STXBP5-AS1/miR-4425/RNF217 axis to suppress breast cancer cell growth.…”
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2928por Gao, Wenhui, Li, Rong, Yu, Jingjing, He, Xijie, Xu, Duo, Zhong, Hai, Dong, Wenwen, Cui, Hanbin“…CONCLUSION: Therefore, SCIRT is downregulated in atherosclerosis and it suppresses the proliferation of HAOSMCs by sponging miR-146a in cytoplasm.…”
Publicado 2021
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2929por Xu, Zhenjun, Zhong, Kai, Guo, Guanjun, Xu, Can, Song, Zhizhao, Wang, Dongjin, Pan, Jun“…Circ_TGFBR2 served as a sponge for miR-29a targeting KLF4. MiR-29a mimics rescued biological roles induced by circ_TGFBR2 overexpression. …”
Publicado 2021
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2930
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2931por Zhang, Nuobei, Shen, Hao, Huang, Shenan, Wang, Fenfen, Liu, Huifang, Xie, Fen, Jiang, Lei, Chen, Xin“…The long non-coding FGD5-AS1 (LncFGD5-AS1) has been reported to be a novel carcinogenic gene and participant in regulating tumor progression by sponging microRNAs (miRNAs). However, the pattern of expression and the biological role of FGD5-AS1 in hepatocellular carcinoma (HCC) remains largely unknown. …”
Publicado 2021
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2932por Wang, Jingui, Zhang, Xiaoqian, Zhang, Junling, Chen, Shangwen, Zhu, Jing, Wang, Xin“…Previously, we first detected that lncRNA cetuximab resistance-associated RNA transcript 16 (CRART16) could contribute to cetuximab resistance by upregulating V-Erb-B2 erythroblastic leukemia viral oncogene homologue 3 (ERBB3) expression by sponging miR-371a-5p in CRC cells. The current study aimed to explore the role of CRART16 in acquired 5-FU resistance in CRC cells and its possible mechanism. …”
Publicado 2021
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2933por Ji, Yang, Yang, Shikun, Yan, Xueqi, Zhu, Li, Yang, Wenjie, Yang, Xinchen, Yu, Fei, Shi, Longqing, Zhu, Xi, Lu, Yunjie, Zhang, Chuanyong, Lu, Hao, Zhang, Feng“…Moreover, circCRIM1 upregulated the expression of SKP2 by functioning as a sponge for miR-378a-3p. These findings suggest that circCRIM1 boosts the HCC progression via the miR-378-3p/SKP2 axis and may act as a crucial epigenetic therapeutic molecule target in HCC.…”
Publicado 2021
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2934“…CircRNA75 and circRNA72 suppressed coelomocyte apoptosis by sponging miR-200 to promote Tollip expression. The ability of circRNA to adsorb miRNA might be positively related to the number of binding sites for miRNA.…”
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2935
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2936
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2937por Ren, Jing, Qi, Hanping, Song, Chao, Ba, Lina, Liu, Renling, Feng, Xiang, Wang, Lixin, Zhang, Meitian, Xie, Yawen, Sun, Hongli“…Furthermore, lncRNAA02Rik acted as a competing endogenous RNA by sponging miR-135a, while forced expression of lncRNAA02Rik could repress its activity and expression. …”
Publicado 2021
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2938por Zhang, Yi, Tian, Kaisai, Zhou, Enhui, Xue, Xiaocheng, Yan, Shiling, Chen, Yixin, Qiao, Peipei, Yang, Liyun, Chen, Xiaoping“…Our team validated that hsa_circ_0023305 functioned as a miR-218-5p sponge from a mechanistic perspective, targeting the melastatin-related transient receptor potential 7 (TRPM7) in LSCC cells. …”
Publicado 2021
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2939“…In the course of our continuing efforts to identify bioactive secondary metabolites from Red Sea marine sponges, we have investigated the sponge Hemimycale sp. …”
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2940