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3081
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3082por Chen, Liang, Kong, Ruijiao, Wu, Cong, Wang, Shuo, Liu, Zixin, Liu, Shupeng, Li, Shuiping, Chen, Tian, Mao, Chuanbin, Liu, Shanrong“…The discovered braking mechanism of a circRNA, termed mRNA braking, along with its more traditional role of miRNA sponging, uncovers a dual‐faceted pattern of circRNA‐mediated post‐transcriptional regulation for maintaining a specific cell state.…”
Publicado 2019
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3083“…Mechanistically, RGMB-AS1 functioned as a competing endogenous RNA upregulating histone deacetylase 4 (HDAC4) by sponging microRNA-574 (miR-574). Rescue experiments indicated that miR-574 inhibition and HDAC4 reintroduction reversed the effects of the RGMB-AS1 knockdown on GC cells. …”
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3084por He, Jin Hua, Han, Ze Ping, Luo, Jin Gen, Jiang, Jian Wei, Zhou, Jia Bin, Chen, Wei Ming, Lv, Yu Bing, He, Meng Ling, Zheng, Lei, Li, Yu Guang, Zuo, Ji Dong“…Taken together, this study demonstrated that hsa_circ_0007843 acted as an miRNA sponge to regulate MMP2 expression by removing the inhibitory effect of miR-518c-5p on MMP2 gene translation, which further affected the invasive capability of SW480 cells.…”
Publicado 2020
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3085
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3086“…CONCLUSIONS: SNHG1 may promote cell invasion and migration in HCC cells by sponging miR-195. These results can provide deeper understanding of SNHG1 in hepatocellular cancer and give new potential targets for treatment of HCC.…”
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3087“…ASB16-AS1 increased HDGF expression by sponging miR-760, thereby conferring cancer-promoting roles in OS. …”
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3088por Yang, Yi, Ren, Jiandong, Huang, Qilin, Wu, Jun, Yuan, Xiaohui, Jiang, Wen, Wen, Yi, Tang, Lijun, Sun, Hongyu“…Circular RNAs (circRNAs) are emerging as vital regulators of gene expression in various diseases by sponging microRNAs (miRNAs). However, the roles of circRNAs in the pathophysiology of SAP remain unknown. …”
Publicado 2020
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3089por Shen, Xianjuan, Kong, Shan, Yang, Qian, Yin, Qingqing, Cong, Hui, Wang, Xudong, Ju, Shaoqing“…In addition, lncRNA PCAT‐1 functioned to sponge miR‐129 and thereby lowered its expression. …”
Publicado 2020
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3090por Yang, Bairen, Du, Ke, Yang, Chuanhua, Xiang, Lili, Xu, Ying, Cao, Chen, Zhang, Junhui, Liu, Wenneng“…CircPRTM5 exerts critical regulatory role in CRC progression by sponging miR‐377 to induce E2F3 expression.…”
Publicado 2020
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3091
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3092
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3093
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3094por Huang, Tao, Cao, Yanwei, Wang, Hongyang, Wang, Qinghai, Ji, Jianlei, Sun, Xiaoxia, Dong, Zhen“…We demonstrated that circYAP1 activated PI3K/AKT/mTOR pathway and secured HK‐2 cells from I/R injury via sponging miR‐21‐5p.…”
Publicado 2020
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3095“…FOSL2 downregulation and miR-342-3p overexpression suppressed cell proliferation and migratory and invasive abilities while promoting apoptosis and autophagy, all of which were consistent with the effects of LINC00313 knockdown. miR-342-3p, sponged by LINC00313, inversely modulated FOSL2 by targeting MG-63 cells, and FOSL2 expression was positively controlled by LINC00313. …”
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3096por Liu, Minfeng, Luo, Can, Dong, Jianyu, Guo, Jingyun, Luo, Qing, Ye, Changsheng, Guo, Zhaoze“…Taken together, this study showed that circRNA_103809 could inhibit cell proliferation and metastasis in breast cancer by sponging miR-532-3p, and circRNA_103809 might be a prospective target of breast cancer therapy.…”
Publicado 2020
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3097
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3098“…However, the upregulation of MEG3 increased the expression of LAMA4 by sponging miR-30e-3p, which alleviated the malignancy of OC cells. …”
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3099por Wang, Hui, Zhang, Jianming, Xu, Zhiyong, Yang, Jingxin, Xu, Yong, Liu, Yang, Li, Bohong, Xie, Jiansheng, Li, Jing“…CONCLUSIONS: hsa_circ_0000848 expression is significantly down-regulated in the FGR placenta. hsa_circ_0000848 promotes trophoblast cell migration and invasion, and inhibits cell apoptosis via the sponging of hsa-miR-6768-5p. Our study provided a novel insight into mechanisms underlying the pathogenesis of FGR, as well as into new strategies for the treatment of FGR.…”
Publicado 2020
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3100por Zou, Fang-Wen, Yang, Shi-Ze, Li, Wen-Ya, Liu, Chao-Yuan, Liu, Xu-Hong, Hu, Chun-Hong, Liu, Zheng-Hua, Xu, Shun“…RT-qPCR and western blotting further demonstrated that circRNA_001275 serves as an miR-370-3p sponge to upregulate Wnt7a expression. In conclusion, the present study revealed that circRNA_001275 was upregulated in cisplatin-resistant esophageal cancer and promoted cisplatin resistance by sponging miR-370-3p to upregulate Wnt7a expression. …”
Publicado 2020
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