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  1. 9261
    “…Studies have demonstrated that circRNA can function as microRNA (miRNA) sponges or competing endogenous RNAs. Although circRNA has been explored in some species and tissues, the genetic basis of testis development and spermatogenesis in donkeys remain unknown. …”
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    Identification of Circular RNAs of Testis and Caput Epididymis and Prediction of Their Potential Functional Roles in Donkeys
  2. 9262
    por Sjakste, Nikolajs, Gajski, Goran
    Publicado 2023
    “…Alkaloids and terpenoids isolated from sponges such as avarol, ingenamine G or variolin B manifest the capability to bind DNA in vitro and produce DNA breaks. …”
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    A Review on Genotoxic and Genoprotective Effects of Biologically Active Compounds of Animal Origin
  3. 9263
    “…Mechanistic analysis revealed that LINC00460 promoted myelin and lymphocyte protein 2 (MAL2) expression by sponging miR-320a. Moreover, both miR-320a knockdown and MAL2 overexpression could reverse the effects of LINC00460 silencing on cell proliferation and ferroptosis. …”
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    LINC00460 Facilitates Cell Proliferation and Inhibits Ferroptosis in Breast Cancer Through the miR-320a/MAL2 Axis
  4. 9264
    “…In vivo, HKE(2) induced the growth of blood vessels into polyacetal sponges implanted in mice. HKE(2)-mediated effects in vitro and in vivo were blocked by the VEGFR2 inhibitor vatalanib, indicating that the pro-angiogenic effect of HKE(2) was mediated by VEGFR2. …”
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    The 5-lipoxygenase/cyclooxygenase-2 cross-over metabolite, hemiketal E(2), enhances VEGFR2 activation and promotes angiogenesis
  5. 9265
    “…MAAs were mainly identified in algae, sponges, sea cucumber and corals that showed significant UV-absorbing activities. …”
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    Advances on marine-derived natural radioprotection compounds: historic development and future perspective
  6. 9266
    “…We additionally identify SgrS and FnrS as potential new sRNA sponges of CsrA. Overall, our results further support the expanding impact of the Csr system on cellular physiology via CsrA impact on the regulatory roles of these sRNAs.…”
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    CsrA Shows Selective Regulation of sRNA-mRNA Networks
  7. 9267
    “…Scaffold-2s are homogeneous volumetric hard sponges (pore size 30–300 [Formula: see text] m) with more structured pores. …”
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    Poly(3-hydroxybutyrate) 3D-Scaffold–Conduit for Guided Tissue Sprouting
  8. 9268
    por Davies, Sarah W., Gamache, Matthew H., Howe-Kerr, Lauren I., Kriefall, Nicola G., Baker, Andrew C., Banaszak, Anastazia T., Bay, Line Kolind, Bellantuono, Anthony J., Bhattacharya, Debashish, Chan, Cheong Xin, Claar, Danielle C., Coffroth, Mary Alice, Cunning, Ross, Davy, Simon K., del Campo, Javier, Díaz-Almeyda, Erika M., Frommlet, Jörg C., Fuess, Lauren E., González-Pech, Raúl A., Goulet, Tamar L., Hoadley, Kenneth D., Howells, Emily J., Hume, Benjamin C. C., Kemp, Dustin W., Kenkel, Carly D., Kitchen, Sheila A., LaJeunesse, Todd C., Lin, Senjie, McIlroy, Shelby E., McMinds, Ryan, Nitschke, Matthew R., Oakley, Clinton A., Peixoto, Raquel S., Prada, Carlos, Putnam, Hollie M., Quigley, Kate, Reich, Hannah G., Reimer, James Davis, Rodriguez-Lanetty, Mauricio, Rosales, Stephanie M., Saad, Osama S., Sampayo, Eugenia M., Santos, Scott R., Shoguchi, Eiichi, Smith, Edward G., Stat, Michael, Stephens, Timothy G., Strader, Marie E., Suggett, David J., Swain, Timothy D., Tran, Cawa, Traylor-Knowles, Nikki, Voolstra, Christian R., Warner, Mark E., Weis, Virginia M., Wright, Rachel M., Xiang, Tingting, Yamashita, Hiroshi, Ziegler, Maren, Correa, Adrienne M. S., Parkinson, John Everett
    Publicado 2023
    “…In the dinoflagellate family Symbiodiniaceae, which can form endosymbioses with cnidarians (e.g., corals, octocorals, sea anemones, jellyfish), other marine invertebrates (e.g., sponges, molluscs, flatworms), and protists (e.g., foraminifera), molecular data have been used extensively over the past three decades to describe phenotypes and to make evolutionary and ecological inferences. …”
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    Building consensus around the assessment and interpretation of Symbiodiniaceae diversity
  9. 9269
    “…Wound fibroblasts from subcutaneously implanted sponges were used for comparison. The M1/M2 macrophage plasma cytokines were analyzed. …”
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    Ileocolonic Healing after Small Ileocecal Resection in Mice: NOD2 Deficiency Impairs Anastomotic Healing by Local Mechanisms
  10. 9270
    “…Marine organisms (i.e., fish, jellyfish, sponges or seaweeds) represent an abundant and eco-friendly source of collagen. …”
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    Marine Collagen-Based Bioink for 3D Bioprinting of a Bilayered Skin Model
  11. 9271
    por Qin, Meiying, Zhang, Chunmei, Li, Yang
    Publicado 2023
    “…Recent studies have shown that circRNAs can act as miRNA sponges, sequestering miRNAs and preventing them from binding to their target mRNAs. …”
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    Circular RNAs in gynecologic cancers: mechanisms and implications for chemotherapy resistance
  12. 9272
    “…Mechanistically, circGNB1 upregulated the expression of oncogene XPR1 via sponging miR-515-5p and miR-582-3p. The following experiments proved XPR1 could promote the malignant phenotype of GSCs via upregulating IL6 expression and activating JAK2/STAT3 signaling. …”
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    CircGNB1 facilitates the malignant phenotype of GSCs by regulating miR-515-5p/miR-582-3p-XPR1 axis
  13. 9273
    “…RNA immunoprecipitation and dual‐luciferase reporter assays demonstrated that circ‐TNRC6B sponges oncogenic miR‐452‐5p to upregulate the expression and activity of DAG1. …”
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    Circular RNA circ‐TNRC6B inhibits the proliferation and invasion of esophageal squamous cell carcinoma cells by regulating the miR‐452‐5p/DAG1 axis
  14. 9274
    “…Of these, 179 circRNAs were predicted to function as “miRNA sponges”. Some distinctive circRNAs and mRNAs found by ceRNA analysis might be involved in autophagy in SICM. …”
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    Identification of autophagy-associated circRNAs in sepsis-induced cardiomyopathy of mice
  15. 9275
    “…Manoalide is a natural sesterterpenoid isolated from marine sponges. It is a phospholipase A2 inhibitor with anti-inflammatory, analgesic, and anti-cancer properties. …”
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    Manoalide Induces Intrinsic Apoptosis by Oxidative Stress and Mitochondrial Dysfunction in Human Osteosarcoma Cells
  16. 9276
    “…Mechanistically, circ_0042881 promoted BC progression by sponging miR-217 to relieve its inhibition effect in son of sevenless 1 (SOS1), which further activated RAS protein and initiated downstream signaling cascades, including MEK/ERK pathway and PI3K/AKT pathway. …”
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    EIF4A3-mediated circ_0042881 activates the RAS pathway via miR-217/SOS1 axis to facilitate breast cancer progression
  17. 9277
    por Li, Guosheng, Chen, Qiang
    Publicado 2023
    “…CONCLUSION: PCA3 served as a biomarker of CAS and regulates the function of VSMCs through sponging miR-124-3p/ITGB1 and indirectly influence the stability of plaque.…”
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    lncRNA PCA3 Suppressed Carotid Artery Stenosis and Vascular Smooth Muscle Cell Function via Negatively Modulating the miR-124-3p/ITGB1 Axis
  18. 9278
    “…Mechanically, this work demonstrates that LINC02568 regulates estrogen/ERα‐induced gene transcriptional activation in trans by stabilizing ESR1 mRNA through sponging miR‐1233‐5p in the cytoplasm. Meanwhile, LINC02568 contributes to tumor‐specific pH homeostasis by regulating carbonic anhydrase CA12 in cis in the nucleus. …”
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    Estrogen‐Induced LncRNA, LINC02568, Promotes Estrogen Receptor‐Positive Breast Cancer Development and Drug Resistance Through Both In Trans and In Cis Mechanisms
  19. 9279
    por Xia, Shaofeng, Wang, Chenliang
    Publicado 2023
    “…For the purpose of the mechanism study, hsa_circ_0003489 knockdown substantially reduced IGF2 expression via miR-98-5p sponging, improving PTX sensitivity in PR NSCLC. CONCLUSION: Through miR-98-5p/IGF2 axis control, hsa_circ_0003489 knockdown helped NSCLC overcome PTX resistance, suggesting a potential circRNA-targeted therapy for the disease.…”
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    Hsa_circ_0003489 Drives PTX Resistance of Human NSCLC Cells Through Modulating miR-98-5p/IGF2
  20. 9280
    “…Circular RNAs (circRNAs) are produced by back-splicing and influence the interactive RNA network by microRNA and protein sponging. In the present study, we aimedto identify circRNAs that derive from the LSD1-encoding KDM1A gene, and to investigate their potential to be released and uptaken by lung cancer versus non-cancer epithelial cells. …”
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    Vesicular Release and Uptake of Circular LSD1-RNAs from Non-Cancer and Cancer Lung Cells
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