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9561por Crane, Meredith J., Xu, Yun, Henry, William L., Gillis, Sean P., Albina, Jorge E., Jamieson, Amanda M.“…We used two complimentary models of injury: the excisional tail wound and subcutaneous implantation of polyvinyl alcohol (PVA) sponges. These models allow for assessment of the rate of closure and measurement of cellular and cytokine responses during acute wound healing, respectively. …”
Publicado 2018
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9562por Chiarello, Marlène, Auguet, Jean-Christophe, Bettarel, Yvan, Bouvier, Corinne, Claverie, Thomas, Graham, Nicholas A. J., Rieuvilleneuve, Fabien, Sucré, Elliot, Bouvier, Thierry, Villéger, Sébastien“…While such microbiomes have been deeply examined in marine invertebrates such as corals and sponges, the microbiomes living on marine vertebrates have received less attention. …”
Publicado 2018
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9563por Fan, Zhimin, Gao, Shanshan, Chen, Yequn, Xu, Bayi, Yu, Chengzhi, Yue, Minghui, Tan, Xuerui“…Additionally, lncRNAs can function as ceRNAs by sponging miRNAs to affect the expression level of mRNAs, implicating in numerous biological processes. …”
Publicado 2018
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9564por Ren, Yongzhe, Yue, Huifang, Li, Le, Xu, Yanhua, Wang, Zhiqiang, Xin, Zeyu, Lin, Tongbao“…Moreover, seven DECs were predicted to have miRNA binding sites and may serve as miRNA sponges to capture miRNAs from their target genes. …”
Publicado 2018
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9565por Chen, Junzheng, Huang, Xitian, Wang, Weijun, Xie, Hongcheng, Li, Jianfeng, Hu, Zhenfen, Zheng, Zhijian, Li, Huiyong, Teng, Lingfang“…Additionally, CDKN2BAS upregulated the expression of Rho GTPase activating protein 18 (ARHGAP18) by sponging microRNA-153-5p (miR-153-5p), and thus promoted HCC cell migration. …”
Publicado 2018
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9566por Ezzat, Shahira M., Bishbishy, Mahitab H. El, Habtemariam, Solomon, Salehi, Bahare, Sharifi-Rad, Mehdi, Martins, Natália, Sharifi-Rad, Javad“…Hence, several marine organisms, including macro and microalgae, sponges, marine invertebrates, sea urchins, seaweeds, soft corals, lichens, and sea grasses, have been recently evaluated as potential drug sources. …”
Publicado 2018
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9567por Pang, Feng, Zhang, Mengmeng, Yang, Xiaojian, Li, Guohua, Zhu, Shu, Nie, Xin, Cao, Ruiyong, Yang, Xiaohong, Zhang, Zhenxing, Huang, Haifeng, Li, Baobao, Wang, Chengqiang, Du, Li, Wang, Fengyang“…The constructed circRNA-miRNA-mRNA network suggested that circRNAs may function as miRNA sponges indirectly regulating gene expression following ORFV infection. …”
Publicado 2019
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9568“…Our analyses point to a potential for circRNA-mediated sponging of miRNAs known to regulate apoptosis. In conclusion, this is the first transcriptomics study that provides a complete circRNA profile of apoptotic cells that might shed light onto the potential role of circRNAs in apoptosis.…”
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9569por Ren, Wen, Yang, Lan, Deng, Tian, Wu, Caijuan, Li, Yuanjing, Wu, Jingwen, Huang, Zhu, Du, Faliang, Guo, Lvhua“…The results demonstrated that mmu_circRNA_003795 can indirectly regulate FOSL2 expression via sponging of miR-504-3p, resulting in alterations in BMSC proliferation.…”
Publicado 2019
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9570por Wen, Juyi, Wang, Hongwei, Dong, Tingjun, Gan, Panpan, Fang, Henghu, Wu, Sudong, Li, Jingjiao, Zhang, Yuanyuan, Du, Rui, Zhu, Qi“…ABHD11‐AS1 acted as a competitive endogenous (ce) RNA to upregulate STAT3 by sponging miR‐1301‐3p. CONCLUSIONS: STAT3‐induced lncRNA ABHD11‐AS1 promoted PTC progression by regulating PI3K/AKT signalling pathway and miR‐1301‐3p/STAT3 axis.…”
Publicado 2019
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9571por Voellenkle, Christine, Perfetti, Alessandra, Carrara, Matteo, Fuschi, Paola, Renna, Laura Valentina, Longo, Marialucia, Sain, Simona Baghai, Cardani, Rosanna, Valaperta, Rea, Silvestri, Gabriella, Legnini, Ivano, Bozzoni, Irene, Furling, Denis, Gaetano, Carlo, Falcone, Germana, Meola, Giovanni, Martelli, Fabio“…Circular RNAs (circRNAs) constitute a recently re-discovered class of non-coding RNAs functioning as sponges for miRNAs and proteins, affecting RNA splicing and regulating transcription. …”
Publicado 2019
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9572“…Virus-encoded miRNA seed sponges (vSSs) can potentially bind to host miRNA seed sites and prevent interaction with their native targets thereby relieving native miRNA suppression. …”
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9573“…Moreover, circCDR1as promoted autophagy in OSCC cells by sponging miR-671-5p. Collectively, these results revealed that high expression of circCDR1as enhanced the viability of OSCC cells under a hypoxic microenvironment by promoting autophagy, suggesting a novel treatment strategy involving circCDR1as and the inhibition of autophagy in OSCC cells.…”
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9574por Chen, Yangzong, Bao, Chunchun, Zhang, Xiuxing, Lin, Xinshi, Huang, Hongou, Wang, Zhiqiang“…HCG11 was predominantly enriched in the cytoplasm of glioma cells and acted as a competing endogenous RNAs (ceRNAs) by sponging micro‐496 to upregulate cytoplasmic polyadenylation element binding protein 3 (CPEB3). …”
Publicado 2019
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9575por Ma, Xuelian, Zhao, Xiaomin, Wang, Kaili, Tang, Xiaoyi, Guo, Jianxiong, Mi, Mi, Qi, Yanping, Chang, Lingling, Huang, Yong, Tong, Dewen“…CONCLUSIONS: The data showed that differentially expressed lncRNAs might be involved in inflammatory response induced by TGEV through acting as miRNA sponges, regulating their up/down-stream genes, or directly binding proteins.…”
Publicado 2019
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9576por Cao, Chuanwu, Han, Shilong, Yuan, Yifeng, Wu, Yongfa, Lian, Weishuai, Zhang, Xiaojun, Pan, Long, Li, Maoquan“…Our results showed that the downregulation of hsa_circ_0000291 suppressed integrin beta 1 (ITGB1) expression via miR-183 “sponging,” which was validated by rescue experiments using the luciferase reporter assay. …”
Publicado 2019
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9577por Wu, Xinquan, Xia, Tianfang, Cao, Meng, Zhang, Pengbo, Shi, Guodong, Chen, Lei, Zhang, Jingjing, Yin, Jie, Wu, Pengfei, Cai, Baobao, Lu, Zipeng, Miao, Yi, Jiang, Kuirong“…We further identified that BRAF-activated noncoding RNA played a vital role in activating the Wnt/β-catenin pathway by sponging miR-195-5p. Collectively, our study showed that BRAF-activated noncoding RNA promotes pancreatic cancer tumorigenesis through miR-195-5p/Wnt/β-catenin axis may serve as a potential target for diagnostics and therapeutics in pancreatic cancer.…”
Publicado 2019
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9578por Ou, Rongying, Lv, Jiangmin, Zhang, Qianwen, Lin, Fan, Zhu, Li, Huang, Fangfang, Li, Xiangyun, Li, Tian, Zhao, Liang, Ren, Yi, Xu, Yunsheng“…Mechanically, circAMOTL1 served as a competing endogenous RNA (ceRNA) to prompt the expression of AMOTL1 through sponging miR-485-5p. Rescue assays revealed that miR-485-5p/AMOTL1 axis was involved in circ_AMOTL1-mediated cervical cancer progression. …”
Publicado 2019
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9579por Li, Yinhui, Yan, Guiling, Zhang, Jie, Chen, Wei, Ding, Tao, Yin, Yupeng, Li, Minghan, Zhu, Yiqing, Sun, Shuhan, Yuan, Ji Hang, Guo, Zhiyong“…Furthermore, rescue experiment results revealed that HOXA11‐AS functioned as a competing endogenous RNA to regulate MCP‐1 expression through sponging miR‐124‐3p and that overexpression of miR‐124‐3p restored the inhibitory effect of proliferation, promotion effects of apoptosis and cell damage induced by HOXA11‐AS overexpression. …”
Publicado 2019
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9580por Donelson, Nathan C., Dixit, Richa, Pichardo-Casas, Israel, Chiu, Eva Y., Ohman, Robert T., Slawson, Justin B., Klein, Mason, Fulga, Tudor A., Van Vactor, David, Griffith, Leslie C.“…In order to define the microRNAs required for normal locomotion in Drosophila melanogaster, we utilized a set of transgenic Gal4-dependent competitive inhibitors (microRNA sponges, or miR-SPs) to functionally assess ca. 140 high-confidence Drosophila microRNAs using automated quantitative movement tracking systems followed by multiparametric analysis. …”
Publicado 2019
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