“…SUMO1P3 enhances Wnt/β‐catenin pathway through sponging miR‐320a, thus contributing to aggressive progression of HCC.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Finally, we constructed a co-expression network and a ceRNA network of DEmRNAs and DElncRNAs to exhibit a potential regulatory mechanism of DElncRNAs, directly regulating protein coding gene expression in cis or in trans and indirectly regulating protein coding gene expression by sponging miRNA. In conclusion, our study provided a landscape of dysregulated lncRNA and mRNA in spinal cord of bone cancer pain and detected novel potential targets for treatment in the future.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Regarding the mechanism, SNHG16 served as a ceRNA by sponging miR-16–5p, which led to the derepression of its target gene SMAD5 and resulted in potentiation of the TGF-β1/SMAD5 pathway to upregulate CD73 expression in Vδ1 T cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSIONS: Our study firstly showed that lncRNA MSC-AS1 aggravated NPC progression by sponging miR-524-5p to increase NR4A2 expression, indicating MSC-AS1 as a novel target for the lncRNA-targeted therapy in NPC.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Mechanistically, circBFAR upregulated mesenchymal-epithelial transition factor (MET) expression via sponging miR-34b-5p. Additionally, circBFAR overexpression increased the expression of MET and activated downstream phosphorylation of Akt (Ser 473) and further activated the MET/PI3K/Akt signaling pathway, which ultimately promoted the progression of PDAC cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Mechanistically, we found that high level of circ_0020710 could upregulate the CXCL12 expression via sponging miR-370-3p. CXCL12 downregulation could reverse the malignant behavior of melanoma cells conferred by circ_0020710 over expression. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Mechanistically, LINC00173 increased insulin receptor substrate 4 (IRS4) expression by sponging microRNA-493 (miR-493), thereby acting as a competing endogenous RNA. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Thus, MCF2L-AS1 positively regulated the expression of Runx2 by sponging miR-33a, and promoted osteogenic differentiation in BMSCs. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSIONS: MALAT1 may modulate HCC cell proliferation, apoptosis, and autophagy via sponging miR-146a, which regulates HCC progression.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…DANCR was found to be sub-localized in cytoplasmic matrix and to mediate murine double minute 2 (MDM2) expression through sponging miR-518a-3p in CC cells, during which the Smad2/3 signaling was activated. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…SNHG17 positively regulated SNORA71B in PC cell lines and other cell lines. SNHG17 sponged miR-339-5p to upregulate STAT5A and therefore to cause transactivation of SNORA71B. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSION: Knockdown of circUBAP2 impeded proliferation and invasion of OS cells by downregulating the expression of YAP1 via sponging miR-641.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSION: The data of this study demonstrated that the hsa_circRNA_000166 could upregulated the expression of gene ELK1 by sponging miR-330-5p, which may contribute to a better understanding of the regulatory circRNA/miRNA/mRNA network and CC pathogenesis.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Mechanistically, miR-507 and miR-515-5p could be sponged by circ_0005394. Furthermore, E2F Transcription Factor 3 (E2F3) and C-X-C motif chemokine ligand 6 (CXCL6) were confirmed as the target of miR-507 and miR-515-5p, respectively. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Moreover, following rescue assays disclosed that circ-DENND4C mediated malignant phenotypes in HCC cells via up-regulating TCF4 through sponging miR-195-5p. CONCLUSION: circ-DENND4C boosted TCF4 expression to modulate malignant behaviors of HCC cells via activating Wnt/β-catenin pathway, which might offer a promising target for HCC treatment.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Repurposed nets served as chicken coops (33% highlands, 20% lowlands), fences (37% highlands, 25% lowlands), tree covers (22% lowlands), curtains (3% highlands), covering bathrooms (1.5% highlands, 9% lowlands), and washing sponges (13% lowlands). No association was found between repurposing and universal access or household net use. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Moreover, LINC00261 was confirmed as a spong of miR23b‐3p and thereby positively regulates NRF2 expression in cardiomyocytes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Additionally, rescue experiments revealed that PCAT-1 served as an oncogene partly through sponging miR-324-5p and upregulating RAP1A in lung cancer cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Collectively, these data indicated that MAFG-AS1 served as a ceRNA to elevate LASP1 levels by sponging miR143, and played an oncogenic role in ESCC. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Thus, the present study demonstrated that NEAT1 regulates TJP3 expression by sponging miR-1321 and enhances the epithelial-mesenchymal transition, invasion and migration of OC cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso