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9921por Xing, Ying, Sun, Xianhua, Li, Feng, Jiang, Xuan, Jiang, Afang, Li, Xiaofan, Lv, Ruiting, Shao, Liwei“…HOXB-AS3 can upregulate ADAM9 expression by sponging miR-498-5p.…”
Publicado 2021
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9922por Wang, Anpeng, Zhang, Te, Wei, Wei, Wang, Hui, Zhang, Zeyu, Yang, Wenming, Xia, Wenjie, Mao, Qixing, Xu, Lin, Jiang, Feng, Dong, Gaochao“…Additionally, our findings showed that LINC00665 was predominately localized in the cytoplasm so as to interact with Ago2 protein, which could function as miRNA sponges. The results of bioinformatics prediction and RNA pull-down assay indicated that LINC00665 directly interacted with miR-195-5p. …”
Publicado 2021
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9923por Yang, Yu-wei, Meng, Xin, Meng, Yuan-yuan, Tang, Hai-kang, Cheng, Ming-hui, Zhang, Zi-qi, Xu, Wen-qing, Long, Wei“…We identified two novel circular RNAs (circRNAs) (circRNA_2909 and circRNA_0323) and two long non-coding RNAs (lncRNAs) (NONMMUT140549.1 and NONMMUT148249.1) that promote expression of HIF1A and NOS2 in the HIF-1 pathway by sponging microRNAs (miRNAs), especially mmu-miR-92a-1-5p. …”
Publicado 2021
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9924“…CONCLUSIONS: SNHG20 promoted cell proliferation and invasion by sponging miR-217 in ovarian cancer. These results suggested that SNHG20 and miR-217 might provide new targets for therapeutic application in ovarian cancer. …”
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9925por Hung, Huey-Shan, Kung, Mei-Lang, Chen, Fang-Chung, Ke, Yi-Chun, Shen, Chiung-Chyi, Yang, Yi-Chin, Tang, Chang-Ming, Yeh, Chun-An, Hsieh, Hsien-Hsu, Hsu, Shan-hui“…Our results showed that Au-deposited GO nanocomposites, especially GO-Au (×2), significantly exhibited increased cell viability of MSCs, had good anti-oxidative ability, sponged the immune response toward monocyte-macrophage transition, as well as inhibited the activity of platelets. …”
Publicado 2021
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9926por Zhang, Peng-peng, Han, Qiu, Sheng, Ming-xuan, Du, Chun-yu, Wang, Ya-ling, Cheng, Xiao-fang, Xu, Hai-xia, Li, Cen-cen, Xu, Yong-jie“…Following rigorous selection, we found that many up-regulated circRNAs contain multiple miRNAs binding sites, such as miR17, miR-30c, and miR-130, indicating they may potentially facilitate their regulatory functions by acting as miRNA sponges. These results suggest that plenty of circRNAs are expressed in white adipogenesis and the DECs may serve as new candidates for future adipogenesis regulation.…”
Publicado 2021
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9927“…Moreover, LINC00520 positively upregulated FOXP3 expression via sponging miR-3611 in LUAD cells. Subsequently, rescue experiments delineated that miR-3611 downregulation or FOXP3 overexpression reversed the effects of silenced LINC00520 on proliferative and migratory capabilities in LUAD cells. …”
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9928“…Mechanistically, LINC00963 sponged miR-1281 and repressed its expression in CRC cells, resulting in the upregulation of TRIM65. …”
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9929por Kong, Wencheng, Li, Hui, Xie, Lesi, Cui, Guangxing, Gu, Weigang, Zhang, Hongchen, Ma, Wencong, Zhou, Yifeng“…RESULTS: MCF2L-AS1 was highly expressed in CRC cells, and it could enhance the proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) process of CRC cells. MiR-105-5p was sponged by MCF2L-AS1 in CRC cells and Ras-related protein Rab-22A (RAB22A) was verified to be the downstream target of miR-105-5p. …”
Publicado 2021
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9930por Lin, Jiewei, Zhai, Shuyu, Zou, Siyi, Xu, Zhiwei, Zhang, Jun, Jiang, Lingxi, Deng, Xiaxing, Chen, Hao, Peng, Chenghong, Zhang, Jiaqiang, Shen, Baiyong“…Mechanistic investigations revealed that FLVCR1-AS1 acts as a ceRNA to sequester miR-513c-5p or miR-514b-5p from the sponging KLF10 mRNA, thereby relieving their suppressive effects on KLF10 expression. …”
Publicado 2021
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9931“…In conclusion, ST8SIA6-AS1 was indicated to exert an oncogenic function in liver cancer by competitively sponging miR-142-3p.…”
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9932“…DLGAP1‐AS1 depletion inhibited cell proliferation, but induced apoptosis. MiR‐515‐5p could be sponged by DLGAP1‐AS1 in GBM cells and to repress cell proliferation in GBM. …”
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9933“…Barnacles have a calcareous or chitinous membranous base, and their substratum varies from biotic (e.g. corals/sponges) to abiotic surfaces. In this study, we tested the hypothesis that the cement protein (CP) composition and chemical properties of different species vary according to the attachment substrate and/or the basal structure. …”
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9934“…We also showed that OTUD6B-AS1 up-regulated the expression of CCND2 by sponging miR-206. Low miR-206 and high OTUD6B-AS1 expression were associated with significantly poorer overall survival. …”
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9935“…SNHG20 enhanced ROCK1 expression by sponging miR-148a, and the direct binding between SNHG20/ROCK1 and miR-148a was identified. …”
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9936“…This study aimed to explore the mechanism of lncRNA Kcnq1ot1 in AKI by sponging microRNA (miR)-204-5p as a competitive endogenous RNA (ceRNA). …”
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9937“…Further, miR-3614-5p was proven to be sponged by LOXL1-AS1. Additionally, Yin Yang 1 (YY1) was proven as the target gene of miR-3614-5p, and YY1 depletion could repress HCC cell malignant behaviors. …”
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9938por Yuan, Shuang, Zheng, Panchan, Sun, Xiao, Zeng, Judan, Cao, Wenjiao, Gao, Wuyuan, Wang, Yudong, Wang, Lihua“…Mechanistically, hsa_circ_0001860 promoted Smad7 expression by sponging miR-520 h. Conclusion: Hsa_circ_0001860 plays an important role in the development of MPA resistance in EC through miR-520h/Smad7 axis, and it could be targeted to reverse the MPA resistance in endometrial cancer.…”
Publicado 2021
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9939por Yang, Jian, Tian, Shuaiwei, Wang, Baocheng, Wang, Jiajia, Cao, Liangliang, Wang, Qinhua, Xie, Wanqun, Liang, Zhuangzhuang, Zhao, Heng, Zhao, Yang, Liao, Keman, Ma, Jie“…CircPIK3C2A function as competitive endogenous RNA via sponging miR-877-5p through certain binding sites, thereby modulating the expression of FOXM1. …”
Publicado 2021
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9940por Yu, Jia, Zhang, Haining, Zhao, Chunsheng, Li, Guanghui, Zhang, Yingying, Sun, Yang“…Mechanically, circ_0008037 regulated nuclear ubiquitous casein kinase and cyclin‐dependent kinase substrate 1 (NUCKS1) expression via sponging miR‐433‐3p. Furthermore, MiR‐433‐3p inhibitor reversed the inhibiting influence of circ_0008037 silencing on proliferation, migration, invasion, and the Warburg effect of NSCLC cells. …”
Publicado 2021
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