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10141“…BACKGROUND: Circular RNAs (circRNAs) may regulate the onset and progression of human malignancies by competitively binding to microRNA (miRNA) sponges, thus regulating the downstream genes. However, aberrant circRNA expression patterns and their biological functions in prostate cancer (PCa) warrant further studies. …”
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10142por Sanchez-Briñas, Alejandra, Duran-Ruiz, Carmen, Astola, Antonio, Arroyo, Marta Marina, Raposo, Fátima G., Valle, Antonio, Bolivar, Jorge“…Among them, ZNF330/NOA36 stand out because it is a highly evolutionarily conserved nucleolar zinc-finger protein found in the genome of ancient animal phyla like sponges or cnidarians, up to humans. Firstly described as a human autoantigen, NOA36 is expressed in all tissues and human cell lines, and it has been related to apoptosis in human cells as well as in muscle morphogenesis and hematopoiesis in Drosophila. …”
Publicado 2023
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10143“…CircERBB2IP could mediate PSAT1 expression via sponging miR‐5195‐3p. CONCLUSION: In conclusion, circERBB2IP may drive NSCLC growth by the miR‐5195‐3p/PSAT1 axis in NSCLC, shedding light on a diagnostic biomarker and therapeutic target for NSCLC.…”
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10144“…Mechanistically, circFGFR4 competitively sponged miR-185-5p and prevented miR-185-5p from decreasing the levels of C-X-C motif chemokine receptor 4 (CXCR4). …”
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10145por Tan, Cheng, Wei, Jun, Li, Zhaohui, Tian, Nan, Wang, Zhengming, Wang, Guan, Han, Liang, Tian, Yu“…Mechanistic analysis revealed that circ_0021350 sponged miR-1207-3p to regulate PIK3R3, whose overexpression reversed the reduction in the malignant biological behavior of glioma cells caused by silencing circ_0021350. …”
Publicado 2023
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10146por Meng, Li-Wei, Yuan, Guo-Rui, Chen, Meng-Ling, Zheng, Li-Sha, Dou, Wei, Peng, Yu, Bai, Wen-Jie, Li, Zhen-Yu, Vontas, John, Wang, Jin-Jun“…Our analyses find an upstream transcriptional regulatory signal of miR-994 cascade, long noncoding RNA (lnc19419), that indirectly upregulates CPCFC in cuticle of the resistant strain by sponging miR-994. Thus, we elucidate the mechanism of cuticular competing endogenous RNAs for regulating insecticide penetration and demonstrate it also exists in field strain of oriental fruit fly. …”
Publicado 2023
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10147por Li, Jingwei, Lin, Jiewei, Ji, Yuchen, Wang, Xuelong, Fu, Da, Wang, Weishen, Shen, Baiyong“…LINC01133 functioned as a competing endogenous RNA to sequester miR-30b-5p from sponging SIRT1 mRNA to inhibit PAAD pyroptosis. CONCLUSION: With significant prognostic value, our PRL signature are involved in the biological processes of PAAD cells and associated with the immune environment. …”
Publicado 2023
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10148por Furtado, Daniel P., Vieira, Edson A., Nascimento, Wildna Fernandes, Inagaki, Kelly Y., Bleuel, Jessica, Alves, Marco Antonio Zanata, Longo, Guilherme O., Oliveira, Luiz S.“…Corals are colonial animals within the Phylum Cnidaria that form coral reefs, playing a significant role in marine environments by providing habitat for fish, mollusks, crustaceans, sponges, algae, and other organisms. Global climate changes are causing more intense and frequent thermal stress events, leading to corals losing their color due to the disruption of a symbiotic relationship with photosynthetic endosymbionts. …”
Publicado 2023
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10149“…The two seamount sites and the Shackleton Fracture Zone showed high numbers of stylasterid (lace) and alcyonacean (soft) corals, as well as large numbers of sponges. Though data are preliminary, the geological and environmental variability (particularly in temperature) between sample sites may be influencing cold-water coral biogeography in this region. …”
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10150por Seaton, Kelly E., Ballweber, Lamar, Lan, Audrey, Donathan, Michele, Hughes, Sean, Vojtech, Lucia, Moody, M. Anthony, Liao, Hua-Xin, Haynes, Barton F., Galloway, Christine G., Richardson, Barbra A., Karim, Salim Abdool, Dezzutti, Charlene S., McElrath, M. Juliana, Tomaras, Georgia D., Hladik, Florian“…METHODS AND FINDINGS: We first conducted a pilot study to compare three sampling devices (Dacron swabs, flocked nylon swabs and Merocel sponges) for detection of HIV-1-specific IgG and IgA antibodies in vaginal secretions. …”
Publicado 2014
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10151por Xu, Dongbo, Han, Linna, Li, Chunhui, Cao, Qi, Zhu, Duolong, Barrett, Nolan H., Harmody, Dedra, Chen, Jing, Zhu, Haining, McCarthy, Peter J., Sun, Xingmin, Wang, Guojun“…In this study, we evaluated 50 actinobacteria strains derived from diverse deep water sponges and environmental niches for their anti-microbial activities against a panel of pathogens including Candida albicans, Clostridium difficile, Staphylococcus aureus, and methicillin-resistant S. aureus (MRSA), and Pseudomonas aeruginosa. …”
Publicado 2018
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10152por Liu, Yi-Sheng, Lin, Chia-Ying, Chuang, Ming-Tsung, Lin, Chia-Ying, Tsai, Yi-Shan, Wang, Chien-Kuo, Ou, Ming-Ching“…We evaluated the efficacy and safety of conventional transarterial chemoembolization using gelatin sponges or microspheres plus lipiodol-doxorubicin (cTACE) and TACE with doxorubicin-loaded drug eluting beads (DEB-TACE). …”
Publicado 2018
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10153por Tang, Hailin, Huang, Xiaojia, Wang, Jin, Yang, Lu, Kong, Yanan, Gao, Guanfeng, Zhang, Lijuan, Chen, Zhe-Sheng, Xie, Xiaoming“…Luciferase reporter assay and RNA immunoprecipitation assay revealed that circKIF4A and KIF4A could bind to miR-375 and that circKIF4A regulated the expression of KIF4A via sponging miR-375. CONCLUSIONS: The circKIF4A-miR-375-KIF4A axis regulates TNBC progression via the competitive endogenous RNA (ceRNA) mechanism. circKIF4A may therefore serve as a prognostic biomarker and therapeutic target for TNBC. …”
Publicado 2019
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10154por Qi, Xuefei, Chen, Huilong, Fu, Bohua, Huang, Zhenli, Mou, Yong, Liu, Juan, Xu, Yongjian, Xiong, Weining, Cao, Yong“…They might affect RAPGEF3 as miRNA sponges to regulate COPD development.…”
Publicado 2019
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10155“…Conclusion: SNHG6 knockdown suppressed cell migration, invasion, and EMT at least partly by sponging miR-26a and regulating EZH2 expression in CRC cells, providing a strategy for blocking CRC metastasis.…”
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10156“…Besides, MALAT1 promoted proliferation, mobility, migration, and invasion of NSCLC cells via sponging miR-200a-3p. PD-L1 was validated as a target of miR-200a-3p, and indirectly modulated by MALAT1. …”
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10157“…CONCLUSION: Taken together, these findings suggested that DLEU1 regulated MEF2D expression to promote glioma progression by sponging miR-421 and that DLEU1 might be a potential therapeutic target for glioma.…”
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10158por Rausch, Philipp, Rühlemann, Malte, Hermes, Britt M., Doms, Shauni, Dagan, Tal, Dierking, Katja, Domin, Hanna, Fraune, Sebastian, von Frieling, Jakob, Hentschel, Ute, Heinsen, Femke-Anouska, Höppner, Marc, Jahn, Martin T., Jaspers, Cornelia, Kissoyan, Kohar Annie B., Langfeldt, Daniela, Rehman, Ateequr, Reusch, Thorsten B. H., Roeder, Thomas, Schmitz, Ruth A., Schulenburg, Hinrich, Soluch, Ryszard, Sommer, Felix, Stukenbrock, Eva, Weiland-Bräuer, Nancy, Rosenstiel, Philip, Franke, Andre, Bosch, Thomas, Baines, John F.“…The goal of the Collaborative Research Center “Origin and Function of Metaorganisms” is to understand why and how microbial communities form long-term associations with hosts from diverse taxonomic groups, ranging from sponges to humans in addition to plants. METHODS: In order to optimize the choice of analysis procedures, which may differ according to the host organism and question at hand, we systematically compared the two main technical approaches for profiling microbial communities, 16S rRNA gene amplicon and metagenomic shotgun sequencing across our panel of ten host taxa. …”
Publicado 2019
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10159“…Mechanistically, SNHG14 sponged miR-5590-3p to upregulate Zinc finger E-box binding homeobox 1 (ZEB1), and ZEB1 transcriptionally activated SNHG14 and PD-L1 to promote the immune evasion of DLBCL cells. …”
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10160por Zhang, Lei, Zhou, Qing, Qiu, Qiongzi, Hou, Ling, Wu, Mengting, Li, Jia, Li, Xufan, Lu, Bingjian, Cheng, Xiaodong, Liu, Pengyuan, Lu, Weiguo, Lu, Yan“…Further analyses showed that circPLEKHM3 sponged miR-9 to regulate the endogenous expression of BRCA1, DNAJB6 and KLF4, and consequently inactivate AKT1 signaling. …”
Publicado 2019
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