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  1. 2121
    “…We outline the methodologies implemented for their establishment, the culture protocols for their long-term maintenance, and their basic molecular characterization. Further, we spotlight any cell lines that express fluorescent reporters. …”
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    An expedition in the jungle of pluripotent stem cells of non-human primates
  2. 2122
    “…Particularly, ACT using T cells equipped with chimeric antigen receptors (CARs) has moved into the spotlight in clinical studies. However, the efficacy of ACT is challenged by ACT-intrinsic factors, like lack of activation or T cell exhaustion, as well as immune evasion strategies of paediatric solid tumours, such as their highly immunosuppressive microenvironment. …”
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    Adoptive cell therapy in paediatric extracranial solid tumours: current approaches and future challenges
  3. 2123
    por Morell, Emily A., Balkin, Daniel M.
    Publicado 2010
    “…Staphylococcus aureus (S. aureus) has entered the spotlight as a globally pervasive drug-resistant pathogen. …”
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    Methicillin-Resistant Staphylococcus Aureus: A Pervasive Pathogen Highlights the Need for New Antimicrobial Development
  4. 2124
    por Blignaut, Marguerite
    Publicado 2012
    “…Advances in sequencing and detection technology over the past two decades, highlighted by the data explosion brought about by the human genome project, have transformed what was previously assumed to be a relatively simple genetic landscape into a new picture where the so-called “dark matter” of the genome has stolen the spotlight from the not so hip protein-coding genes. …”
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    Review of Non-coding RNAs and the epigenetic regulation of gene expression: A book edited by Kevin Morris
  5. 2125
    por Oldenborg, Per-Arne
    Publicado 2013
    “…By binding to another cell surface glycoprotein, signal regulatory protein alpha (SIRPα), CD47 can regulate the function of cells in the monocyte/macrophage lineage. In this spotlight paper, several functions of CD47 will be reviewed, although some functions may be more briefly mentioned. …”
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    CD47: A Cell Surface Glycoprotein Which Regulates Multiple Functions of Hematopoietic Cells in Health and Disease
  6. 2126
    “…BACKGROUND: Congenital chloride diarrhea (CCD), a rare autosomal recessive disorder, is characterized by sustained watery diarrhea (due to defect of active Chloride/HCO3 exchange in the ileum and colon) with high fecal chloride. OBJECTIVE: To spotlight the common presentation of CCD for early management and prevention of complications. …”
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    Congenital chloride diarrhea: a review of twelve Arabian children
  7. 2127
    por Sakhrani, Niraj M, Padh, Harish
    Publicado 2013
    “…Nanoparticles play a crucial role by acting as a vehicle for delivery of drugs to target sites inside tumor cells. In this review, we spotlight active and passive targeting, followed by discussion of the importance of targeting to specific cell organelles and the potential role of cell-penetrating peptides. …”
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    Organelle targeting: third level of drug targeting
  8. 2128
    por Gressner, A M, Weiskirchen, R
    Publicado 2006
    “…The present review summarises the actual knowledge on the pathogenesis of hepatic fibrogenesis, the role of transforming growth factor-β and its signalling pathways in promoting the fibrogenic response, and the therapeutic modalities that are presently in the spotlight of many investigations and are already on the way to take the plunge into clinical studies.…”
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    Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-β as major players and therapeutic targets
  9. 2129
    “…Plant-based compounds have been in the spotlight in search of new and promising drugs. Flavokawain A, B and C are naturally occurring chalcones that have been isolated from several medicinal plants; namely the piper methysticum or commercially known as the kava-kava. …”
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    The flavokawains: uprising medicinal chalcones
  10. 2130
    por Loebrich, Sven
    Publicado 2014
    “…Recent evidence from human genetics puts postsynaptic organization, glutamate receptor trafficking, and F-actin remodeling in the spotlight as candidate mechanisms underlying neuropsychiatric disorders. …”
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    The role of F-actin in modulating Clathrin-mediated endocytosis: Lessons from neurons in health and neuropsychiatric disorder
  11. 2131
    “…We examine the impact on target protein function and regulation by mitochondrial sirtuins. Finally, we spotlight work in the heart and cardiac mitochondria, and consider the roles acetylation and other newly-found modifications may play in heart disease.…”
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    Metabolism leaves its mark on the powerhouse: recent progress in post-translational modifications of lysine in mitochondria
  12. 2132
    “…Moreover, we provide a spotlight on the future perspectives in systemic therapy for advanced GC/GEJ cancer.…”
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    Critical evaluation of ramucirumab in the treatment of advanced gastric and gastroesophageal cancers
  13. 2133
    “…A current model for the microcephaly phenotype invokes a stem cell proliferation and differentiation defect, which has moved the disease into the spotlight of stem cell biology and neurodevelopmental science. …”
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    Novel Alternative Splice Variants of Mouse Cdk5rap2
  14. 2134
    “…Visual attention spreads over a range around the focus as the spotlight metaphor describes. Spatial spread of attentional enhancement and local selection/inhibition are crucial factors determining the profile of the spatial attention. …”
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    Visual attention spreads broadly but selects information locally
  15. 2135
    “…Our findings suggest that high-frequency binaural beats bias the individual attentional processing style towards a reduced spotlight of attention.…”
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    More attentional focusing through binaural beats: evidence from the global–local task
  16. 2136
    “…Rather than remove the spotlight from the patients, it widens that light to illuminate moral interests of all healthcare participants as persons whose welfare is interdependent. …”
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    Beyond patient-centered care: person-centered care for Parkinson’s disease
  17. 2137
    “…Similarly, vitamin D deficiency (VDD) has been in the spotlight as a major global public healthcare burden. …”
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    Vitamin D and Infectious Diseases: Simple Bystander or Contributing Factor?
  18. 2138
    “…In this review, we will outline structural and functional features of coding and noncoding macrosatellite repeats, and highlight recent findings that bring these sequences into the spotlight of genome organization and disease development.…”
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    Emerging roles of macrosatellite repeats in genome organization and disease development
  19. 2139
    “…Several particles, within the spotlight of the researchers, have been SCCA, Ki-67, Bcl-2, Wnt proteins, and many more. …”
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    Risk Factors of Recurrence and Malignant Transformation of Sinonasal Inverted Papilloma
  20. 2140
    “…Therefore, extending health span with pharmacological agents targeting aging-related pathological changes, are now in the spotlight of gerosciences. Panax notoginseng (Burk.) …”
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    Therapeutic Potential and Cellular Mechanisms of Panax Notoginseng on Prevention of Aging and Cell Senescence-Associated Diseases
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