“…METHODS: All specimens were tested with 22C3, 28-8, and SP142 assays following the manufacturer’s established staining protocols. RESULTS: The same PD-L1 status (defined as tumor cell expression (TC) scores with all three assays ≥1% or all <1%) was observed in 60.0% (251/418) tumor specimens (45.9% (192/418) were triple negative and 14.1% (59/418) were triple positive). …”
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“…PTEN protein was unaffected by miR-21 inhibition.In further experiments, transfected cells were exposed to BPA, and apoptosis was examined. Using Annexin V/PI staining, a significant decrease in healthy cells and an increase in early apoptotic cells within inhibited untreated groups was shown (p=0.0395 and 0.0193, n=3). …”
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“…Immunohistochemistry and immunofluorescence studies were performed in pubertal female mice. Abundant staining for Mecp2 was demonstrated in multiple hypothalamic nuclei (arcuate, suprachiasmatic, and paraventricular) and in the median eminence. …”
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“…The histology was diagnostic of an adenoma, and immunohistochemical staining was positive for GH and PRL, but not ACTH. …”
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“…We performed a retrospective study in patients with Cushing's disease (CD) and those with a clinically non-functioning ACTH-staining adenoma (NF-ACTH+) who underwent endoscopic endonasal resection at a large academic health center from 1/2015-7/2021 to investigate whether there are differences in weight-gain trajectories that can help differentiate patients with Cushing's from those without, even in a population that is predominantly overweight-obese. …”
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“…Kaplan-Meier survival curve analysis shows strong statistical correlation in the recurrence free survival (p<0. 0001) and the nuclear positive staining of β-catenin pSer552 with a hazard ratio of 3.1 (95% CI 1.5-6.3). …”
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“…The precaval node was a paraganglioma (PGL) with a preserved SDHB staining, negative cytokeratine 8/18 and a Ki-67 of 1.65%. …”
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“…IHC slides were imaged and observed to score the level of c-MET staining (-, 1+ to 5+). A score of 3+ or higher was considered consistent with overexpression. …”
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“…To identify changes in the number and/or type of proliferating cells as a result of gestational BPA exposure and diet changes, brains from mice sacrificed at P54 and P75 were co-stained for BrdU and cell type specific markers to label neurons, oligodendrocytes, or astrocytes. …”
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“…Parathyroid glands were normal on gross exam. PTH staining could not be performed given degree of tumor necrosis DISCUSSION: Hypercalcemia with elevated PTH and negative localization studies, should raise suspicion for ectopic PTH production from underlying malignancy. …”
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“…Median ratios of C5AR1, CLEC4A and NLRP3 specific antibody staining to CD3 positive cells in early-stage NSCLC patients compared to healthy controls were 0.014 [0–0.37] vs. 0.01 [0–0.07, p = 0.13], 0.03 [0–0.87] vs. 0.02 [0–0.13, p = 0.10] and 0.19 [0–0.60] vs. 0.09 [0.02–0.31, p < 0.0001], respectively. …”
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“…Finger-prick blood was screened for Plasmodium falciparum and non-falciparum species using rapid diagnostic tests (RDTs), and duplicate Giemsa-stained thick and thin blood films were examined for malaria parasites. …”
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“…(D) Frequency of mitochondrial superoxide positive lymphocytes and level of mitochondrial superoxide (MFI) were determined by staining the CD8+ T lymphocytes with mitosox red dye. …”
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“…The visual acuity, intraocular pressure (IOP), corneal fluorescein staining scores (CFS), breakup time of tear film (BUT), Schirmer I test, corneal thickness and tear meniscus height (TMH) were observed at 1 day, 1 and 3 months after injury. …”
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“…Bacterial re-colonization was followed by live/dead (SYTO(TM)9 + propidium iodide) bacterial staining and measured by confocal laser scanning microscopy and fluorometry. …”
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“…Stenotrophomonas spp. have primarily been reported as non-pathogenic, plant-probiotic bacteria, despite the presence of some opportunistic human pathogens in the genus. Here, three Gram-stain negative, rod-shaped, non-spore-forming bacteria, designated as strains CPCC 101365(T), CPCC 101269(T), and CPCC 101426 were isolated from surface-sterilized medicinal plant roots of a mulberry plant in Chuxiong of the Yunnan Province, freshwater from Erhai Lake in the Yunnan Province, and sandy soils in the Badain Jaran desert in Inner Mongolia Autonomous Region, China, respectively. …”
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“…Eosinophil infiltration was observed under microscope after hematoxylin and eosin staining of nasal mucosa. Quantitative PCR and Western blot were employed for determination of histamine receptors mRNA expression and PI3K/PKB associated protein levels, respectively. …”
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“…Eligible patients had tumors with at least 20 MUC5AC staining by centralized immunohistochemistry review. …”
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“…Wound healing properties were measured and wound tissue samples were collated, formalin-fixed, wax-embedded, stained (Hematoxylin and Eosin; Van Gieson) and examined for the healing process. …”
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“…METHODS: Multiplex immunofluorescence staining and flow cytometry were used to detect the expression of inhibitory molecules (IMs) and active markers (AMs) in CD8(+)TILs and PBLs, respectively. …”
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