“…Likewise, the desaturation of the C9-C10 bond in the macrocycle to an E double bond produces a substantial reduction in antiproliferative activity. This is in stark contrast to the effect exerted by the same modification in the natural epothilone macrocycle. …”
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“…Australia’s harsh response to asylum seekers, including indefinite mandatory detention and denial of permanent protection for those found to be refugees, starkly demonstrates the ineluctable intersection of mental health, human rights, ethics and social policy, a complexity that the profession is uniquely positioned to understand and hence reflect back to government and the wider society.…”
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“…Here, we report an all-dielectric active metasurface based on electro-optically tunable III–V multiple-quantum-wells patterned into subwavelength elements that each supports a hybrid Mie-guided mode resonance. The quantum-confined Stark effect actively modulates this volumetric hybrid resonance, and we observe a relative reflectance modulation of 270% and a phase shift from 0° to ~70°. …”
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“…In study five (N = 197), we show that, in stark contrast to our empirical findings, people hold strong lay theories that hunger undermines prosociality.…”
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“…In the past two decades, the region has shown balanced to slightly positive glacier budgets, an increase in glacier ice-flow speeds, stable to partially advancing glacier termini, and widespread glacier surge activity. This is in stark contrast to the rest of High Mountain Asia, where glacier retreat and slowdown dominate, and glacier surging is largely absent. …”
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“…Furthermore, to reduce the quantum confined Stark effect (QCSE), nonpolar AlGaN nanowire UV LEDs exploiting the nonpolar nanowire sidewalls have been demonstrated. …”
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“…From resonant elastic X-ray scattering measurements on Cu(2)OSeO(3) with an in-plane magnetic field, we find that a state of perpendicularly ordered skyrmions forms, in stark contrast to the well-studied bulk state. The surface state is stable over a wide temperature range, unlike the bulk state in out-of-plane fields which is confined to a narrow region of the temperature-field phase diagram. …”
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“…Der Virusstamm von 1918 löste im menschlichen Immunsystem eine besonders starke Reaktion aus. Infolge dieser Überreaktion waren Menschen mit einem leistungsfähigen Immunsystem tendenziell stärker betroffen.…”
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“…RNA–protein interactions are the crucial basis for many steps of bacterial gene expression, including post‐transcriptional control by small regulatory RNAs (sRNAs). In stark contrast to recent progress in the analysis of Gram‐negative bacteria, knowledge about RNA–protein complexes in Gram‐positive species remains scarce. …”
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“…There have been reports of M=E/M≡E multiple bonds for the majority of the transition metals, and even some actinide metals. In stark contrast, as the largest subgroup in the periodic table, rare-earth metals (Ln) were scarcely involved in Ln=E/Ln≡E multiple bonds. …”
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“…Here, we now show that, in stark contrast to results published for other PRC2 subunits, genetic depletion of Phf19 increases HSC identity and quiescence. …”
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“…[Image: see text] The contribution of ligand–ligand electrostatic interaction to transition state formation during enzyme catalysis has remained unexplored, even though electrostatic forces are known to play a major role in protein functions and have been investigated by the vibrational Stark effect (VSE). To monitor electrostatic changes along important steps during catalysis, we used a nitrile probe (T46C-CN) inserted proximal to the reaction center of three dihydrofolate reductases (DHFRs) with different biophysical properties, Escherichia coli DHFR (EcDHFR), its conformationally impaired variant (EcDHFR-S148P), and Geobacillus stearothermophilus DHFR (BsDHFR). …”
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“…COVID-19 is respiratory disease that can result in a cytokine storm with stark differences in morbidity and mortality between younger and older patient populations. …”
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“…This finding stood in stark contrast to normally sighted controls and sight-recovery individuals who had developed cataracts later in childhood: both groups exhibited the typical bias of perceiving vision as delayed compared to audition. …”
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“…This commentary shall deal with the basics of COVID-19 ARDS, basics of an ICU ventilator, innovative low-cost ventilators, and the stark differences between the two and why their use may not be appropriate in the condition of our concern. …”
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“…The efforts of science are in stark contrast to those of populism that has introduced division and a self-serving attitude that are not simply ill-matched to tackle the pandemic, but foster its spread and severity. …”
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“…Pandemic related misinformation has previously been associated with decreased adherence to public health recommendations and adverse health effects and evidence from the current pandemic indicates that adherence to public health recommendations is starkly partisan. This study suggests that the political and informational polarization further facilitated by social media platforms such as Twitter may have dire consequences for public health.…”
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“…Through light-sheet microscopy and large-scale imaging quantification, we demonstrate that crypt formation coincides with stark lumen volume reduction. We develop a 3D biophysical model to computationally screen different mechanical scenarios of crypt morphogenesis. …”
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“…The teeth of all vertebrates predominantly comprise the same materials, but their lifespans vary widely: in stark contrast to mammals, shark teeth are functional only for weeks, rather than decades, making lifelong durability largely irrelevant. …”
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“…For a given carbon budget over several decades, different transformation rates for the energy system yield starkly different results. Here we consider a budget of 33 GtCO(2) for the cumulative carbon dioxide emissions from the European electricity, heating, and transport sectors between 2020 and 2050, which represents Europe’s contribution to the Paris Agreement. …”
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