“…Here, we demonstrated that pDCs could be efficiently generated in vitro from common lymphoid progenitors (CLPs) using Flt3 ligand (FL) in three different culture systems, namely feeder-free, BM-feeder and AC-6-feeder. This was in stark contrast to common DC progenitors (CDPs), in which cDCs were prominently generated under the same conditions. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…To assess the in vivo role of SAFB2, and to identify unique functions of the two paralogs, we generated SAFB2(−/−) mice. In stark contrast to SAFB1(−/−), SAFB2(−/−) offspring were born at expected Mendelian ratios and did not show any obvious defects in growth or fertility. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This diverging signaling pattern compared to classical PDGF-receptor signaling is partially coupled to the aberrant cytoplasmic localization of the oncogene, since membrane targeting of FIP1L1-PDGFRα restores activation of MAPK- and PI3K-pathways. In stark contrast to the classical cytokine-induced STAT activation process, STAT activation by FIP1L1-PDGFRα does neither require Janus kinase activity nor Src kinase activity. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Sptlc2(-/-) DC2.4 cells exhibited a stark defect in phagocytosis, were unable to bind fungal particles and failed to form a normal phagocytic cup to engulf C. albicans. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…As the pore size is reduced toward the 1D limit, we observe the following: (i) a suppression of the pressure dependence of the superfluid velocity; (ii) a temperature dependence of v(s) that surprisingly can be well-fitted by a power law with a single exponent over a broad range of temperatures; and (iii) decreasing critical velocities as a function of decreasing radius for channel sizes below R ≃ 20 nm, in stark contrast with what is observed in micrometer-sized channels. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In the UK, much of the debate around these issues has focussed on the established trope of a long-standing ‘north-south divide’, a divide which appears to have deepened in recent decades with the inexorable de-industrialisation of northern Britain presented in stark counterpoint to the burgeoning concentration of wealth in London and the south-east, driven by the financial and ancillary services sectors. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The difference between developed and developing nations is most stark in the realm of healthcare, which translates into CKD hotspots in many regions of South Asian countries. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Studies were largely inconsistent regarding spindle activity differences between clinical and nonclinical groups, with some reporting greater or less activity, while many others reported no group differences. Stark inconsistencies in sample characteristics (e.g., age range and diagnostic criteria) and methods of analysis (e.g., spindle bandwidth selection, visual detection versus digital filtering, absolute versus relative spectral power, and NREM2 versus NREM3) suggest a need for greater use of event-based detection methods and increased research standardization. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In past decades, stark differences in practice pattern, cost, and outcomes of care across regions with similar health demographics have prompted calls for reform. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These assertions, however, stand in stark contrast to the widely held support of TCa screening among practicing public health professionals, advocacy groups, and clinicians. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Although network topology remained constant across the invasion gradient, composition of bacterial communities associated with native legumes changed dramatically as acacias increasingly dominated the landscape. In stark contrast to aboveground interaction networks (e.g. pollination and seed dispersal) we show that invasive legumes do not infiltrate existing native legume–rhizobium networks but rather form novel modules. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Although all of the Cx43 variants could traffic to the cell surface, there were stark differences in gap junction plaque formation, gap junctional intercellular communication, Cx43 phosphorylation, and hemichannel activity among Cx43 variants, as well as subtle differences in myofibroblast differentiation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…When sounds were heard frequently and deviated minimally from the prevailing pattern of covariance among attributes, they were poorly discriminated from one another. In stark contrast, when sounds were heard rarely and markedly violated the pattern of covariance, they became hyperdiscriminable with discrimination performance beyond apparent limits of the auditory system. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Our results demonstrated that ROS-dependent activation of p38, JNK1/2 and Notch3 promoted basal and TGF-β1-induced differentiation and expression of extracellular matrix proteins. In stark contrast, ERK1/2 was suppressed by ROS and exhibited an inhibitory effect on the differentiation but showed a weak promotion on the expression of extracellular matrix proteins. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Both, the pattern of proliferating cells and the expression domain of twist demonstrate the existence of extensive and long‐lived mesodermal bands in a worm‐shaped aculiferan, a situation which is similar to annelids but in stark contrast to conchiferans, where the mesodermal bands are usually rudimentary and ephemeral. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Although subjects showed some improvements in their visual Braille reading accuracy and speed following the course, the effect of word length on reading speed (typically observed in beginning readers) was remained very sizeable through all testing sessions. These results are in stark contrast to Cyrillic, a natural script, where only 3 months of learning were sufficient to achieve relative proficiency. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This qualitative study draws on 22 semi-structured interviews with nine certified nurse-midwives, one neonatologist, nine obstetrician-gynecologists, one psychiatrist, one psychologist, and one sociologist who provide care during gestation, pregnancy, delivery, and post-delivery in the public and private sectors, plus three interviews with two women and the former partner of a woman who underwent the experience. These interviews starkly illustrate the plight facing women carrying nonviable fetuses, including women’s shock upon receiving the diagnosis, their feelings of bereavement and loss, and the clinical practices used in an attempt to ease their suffering under the weight of exceedingly difficult legal restrictions. …”
Enlace del recurso
Enlace del recurso

“…We define dimensionless parameters—capillary, Fourier, Stark, Biot, and Peclet numbers—to characterize the competition between heat transfer within the particle, heat transfer at the particle rim, and capillary motion, for particles of different sizes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Comparisons between strains revealed a stark area of conservation across the ainS-ainR junction, including a large inverted repeat in ainR. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…There has been considerable variability in the components of muscle health which have been investigated in addition to variability in the tools of assessment and protocol for measurement. This is in stark contrast to the validated measurement of bone health across the adult life span. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso