“…However, directing hPSCs into specific neuronal types is complex and requires an accurate protocol that mimics endogenous neuronal development. Here we describe step-by-step a fast feeder-free neuronal differentiation protocol to direct hPSCs to mature forebrain neurons in 37 days in vitro (DIV). …”
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“…We carried out Mendelian randomisation (MR) analyses in two steps using a two-sample approach with SNPs as instrumental variables (IVs) in each step. In step 1 MR, we estimated the causal effect of BMI on peripheral blood DNA methylation (measured at genome-wide level) using 95 BMI-associated SNPs as IVs. …”
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“…The technique of using TBS inhaler was evaluated step by step. Incorrect use was defined as the patient’s inability to complete the key steps in the inhalation manoeuvre. …”
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“…Syphilis self-test kits have step-by-step instructions and an instructional video. …”
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“…The present study sought to provide more explicit evidence and factors of different grades and weights by a series of step-by-step analysis through χ(2) test, logistic regression analysis and decision-tree model. …”
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“…METHODS: We developed a sequential assessment of the risk reduction provided by face coverings using a step‐by‐step approach. The UK Office of National Statistics (ONS) Population Survey data were utilised to determine the baseline total number of community‐derived infections. …”
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“…Of the DSDs, nonclassical congenital adrenal hyperplasia occurs most often. Provide a step-by-step diagnostic workup plan including repeated and expanded biochemical and genetic tests to solve complex cases. …”
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“…Results: The formulas for CF from model are as follows: CF1 = 0.29 * TG + 1.55 * HbA(1) + 1.81 * ADT_Type + 0.04 * Leptin + 0,34* Adiponectin + 0,91* Resistin – 13,82; CF2 = 0.05*TG + 1.36 * HbA(1) + 3.01 * ADT_Type + 0.08 * Leptin + 0,35* Adiponectin + 1,01 * Resistin – 15.95. A step-by-step approach to diagnostic decision making should be used. …”
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“…On the basis of the key parameters for the one-pot synthesis strategy of {Bi(3)W(43)}, a rational step-by-step approach was developed using the known Krebs-type polyoxotungstate (POT) K(12)[Sb(V)(2)W(VI)(22)O(74)(OH)(2)]·27H(2)O {Sb(2)W(22)} as a nonlacunary precursor leading to the synthesis and characterization of {Sb(3)W(43)} and {Co(3)Sb(3)W(42)}. …”
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“…There would likely be value in developing a population-based operational definition of CE, with a step-by-step manual on ‘how to do CE.’ The data from this study also indicate the importance of including CE indicators in national datasets and developing a compendium documenting CE best-practices. …”
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“…Most of these participants were sexual minority cisgender males (91%), and the remainder were identified as members of gender minority groups. We outlined step-by-step instructions on training staff, engaging users, and scheduling and tracking recruitment activities. …”
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“…Exertional Rehabilitation (EP) is a graded protocol of aerobic exercise ranging from light linear exertion (Step 1) to submaximal linear exertion (Step 4)(1,2). In our 5 Step Protocol, Step 4 is followed by standardized multi-directional functional movements at high intensity intervals (Step 5) to rule out ongoing exertional intolerance. …”
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“…However, the burnout of village doctors is gravely threatening the stability of rural primary medical system step by step. This study systematically evaluated the effects of personality, work engagement and alexithymia on burnout of village doctors, and further measured and assessed the mediating effect of alexithymia and work engagement in the association between personality and burnout. …”
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“…They identified nonjudgmental support, peer companionship, and access to step-by-step guidance as facilitators of youth mental wellness. …”
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“…On the other hand, there are also mandatory requirements as a stable internet connection and technical equipment (i.e. webcam, microphone). Overall, a step by step development of a web-based workshop, based on the experience of the live workshop, can be regarded as advantageous. …”
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“…In Ontario, the actions that would most likely encourage the respondent to start PrEP were short waiting time (63%), the healthcare provider informing about their HIV risk being higher than perceived (62%) and a written step-by-step guide (60%). In British Columbia, the actions that would most likely encourage the respondent to start PrEP were short waiting time (68%), people speaking publicly about PrEP (68%) and their healthcare provider counselling about: their HIV risk being higher than perceived (64%), side effects of PrEP (64%) and about how PrEP works (62%). …”
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“…In collaboration with maternity care experts and individuals with recent breastfeeding experience, we designed a one-page toolkit that describes the process of BMHE and includes step-by-step instructions and images to illustrate the technique. …”
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“…However, there is still a lack of comparison of the short and long-term efficacy between the “One-step” and “Step-up” approach. Consequently, we are conducting this clinical trial to provide a reference for IPN treatment. …”
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“…During each simulation, the students’ step-by-step actions were logged into the program database for offline analysis. …”
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“…Researchers aiming to develop a complex psychosocial intervention for a vulnerable target group could use the step-by-step approach described in this paper. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12887-022-03247-9.…”
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