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141por Alshebremi, Mohammad, Tomchuck, Suzanne L, Myers, Jay T, Kingsley, Daniel T, Eid, Saada, Abiff, Muta, Bonner, Melissa, Saab, Shahrazad T, Choi, Sung Hee, Huang, Alex Yee-Chen“…Our data also highlight an urgent need to further characterize tumor cell-intrinsic STING pathways and the associated downstream inflammatory response evoked by cryoablation and other STING-dependent therapy approaches.…”
Publicado 2023
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142por Reus, Joshua B., Trivino-Soto, Guillermo S., Wu, Lily I., Kokott, Kristiana, Lim, Efrem S.“…Several DNA viruses have evolved antagonists to inhibit the cyclic GMP–AMP synthase (cGAS)-stimulator of interferon genes (STING) DNA-sensing immune pathway. This includes DNA viral oncogenes that antagonize the cGAS-STING pathway by binding STING through the LxCxE motif. …”
Publicado 2020
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143por Gkitsaki, Ioanna, Papachristoforou, Alexandros, Michailidou, Sofia, Karamvalis, Nikolaos, Iliadis, Ioannis, Graikini, Dimitra, Sakarikou, Christina, Tsoukis, Evangelos, Argyriou, Anagnostis, Giaouris, EfstathiosEnlace del recurso
Publicado 2023
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144por Neshich, Goran, Mancini, Adauto L., Yamagishi, Michel E. B., Kuser, Paula R., Fileto, Renato, Pinto, Ivan P., Palandrani, Juliana F., Krauchenco, João N., Baudet, Christian, Montagner, Arnaldo J., Higa, Roberto H.“…The Sting Report is a versatile web-based application for extraction and presentation of detailed information about any individual amino acid of a protein structure stored in the STING Database. …”
Publicado 2005
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145por Nandakumar, Ramya, Tschismarov, Roland, Meissner, Felix, Prabakaran, Thaneas, Krissanaprasit, Abhichart, Farahani, Ensieh, Zhang, Bao-cun, Assil, Sonia, Martin, Amandine, Bertrams, Wilhelm, Holm, Christian K, Ablasser, Andrea, Klause, Tanja, Thomsen, Martin K, Schmeck, Bernd, Howard, Kenneth A, Henry, Thomas, Gothelf, Kurt V, Decker, Thomas, Paludan, Søren R“…Here we report that Listeria DNA is sorted into extracellular vesicles (EV)s in infected cells and delivered to bystander cells to stimulate the cGAS-STING pathway. This was also observed during infections with Francisella tularensis and Legionella pneumophila. …”
Publicado 2019
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146por Liu, Yong, Shu, Hongmei, Long, Youlin, Nie, Xiaoqin, Tang, Hongfu, Tu, Lang, Zhang, Hao, Qiu, Gang, He, Daihua, Huang, Qiang, Zhang, Qi, Qing, Shuang, Xu, Donglin, Xia, Hongtao“…BACKGROUND: In recent years, the incidence of wasp sting has increased annually in China. Organ damage and high mortality due to mass wasp envenomation remain major challenges. …”
Publicado 2021
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147“…SIMPLE SUMMARY: Information about fatalities due to stinging insects is scarce. Hymenopteran-related deaths (n = 1691) in 32 European countries based on official registers over a 23-year period (1994–2016) are described. …”
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148por Zheng, Wanglong, Xia, Nengwen, Zhang, Jiajia, Cao, Qi, Jiang, Sen, Luo, Jia, Wang, Hui, Chen, Nanhua, Zhang, Quan, Meurens, François, Zhu, Jianzhong“…Further, the results indicated that ASFV p17 was located in ER and Golgi apparatus, and interacted with STING. ASFV p17 could interfere the STING to recruit TBK1 and IKKϵ through its interaction with STING. …”
Publicado 2022
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151por Govindarajulu, Manoj, Ramesh, Sindhu, Beasley, McNeil, Lynn, Graham, Wallace, Caleigh, Labeau, Sammie, Pathak, Suhrud, Nadar, Rishi, Moore, Timothy, Dhanasekaran, Muralikrishnan“…We discuss the principal elements of the cGAS–STING signaling pathway and the mechanisms underlying the association between cGAS–STING activity and various AD pathologies. …”
Publicado 2023
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152por Ferecskó, Alex S., Smallwood, Miranda J., Moore, Adrian, Liddle, Corin, Newcombe, Jia, Holley, Janet, Whatmore, Jacqueline, Gutowski, Nicholas J., Eggleton, Paul“…Background: Some neurodegenerative diseases have an element of neuroinflammation that is triggered by viral nucleic acids, resulting in the generation of type I interferons. In the cGAS-STING pathway, microbial and host-derived DNA bind and activate the DNA sensor cGAS, and the resulting cyclic dinucleotide, 2′3-cGAMP, binds to a critical adaptor protein, stimulator of interferon genes (STING), which leads to activation of downstream pathway components. …”
Publicado 2023
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153“…METHODS: The candidate molecule, STING (stimulator of interferon genes, encoded by Sting1), was identified by microarray analysis of OA-like mouse chondrocytes. …”
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154“…The use of STING agonists is gaining momentum in breast cancer research. …”
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155por Hsiao, Wan-Chi, Niu, Guang-Hao, Lo, Chen-Fu, Wang, Jing-Ya, Chi, Ya-Hui, Huang, Wei-Cheng, Tung, Chun-Wei, Sung, Ping-Jyun, Tsou, Lun Kelvin, Zhang, Mingzi M.“…We showed that the epoxylactone warhead of excB is required to covalently engage STING at its membrane-proximal Cys91, inhibiting STING palmitoylation and signaling. …”
Publicado 2023
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156“…The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway plays a significant role in health and disease. …”
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157“…The cGAS/STING pathway provides a key host defense mechanism by detecting the accumulation of cytoplasmic double‐stranded DNA (dsDNA) and mediating innate and adaptive immune signaling. …”
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158por Varga, Kornél Z., Gyurina, Katalin, Radványi, Ádám, Pál, Tibor, Sasi-Szabó, László, Yu, Haidong, Felszeghy, Enikő, Szabó, Tamás, Röszer, Tamás“…Cytosolic DNA activates the stimulator of interferon response genes (STING), a key signal transducer which triggers type I interferon (IFN-I) expression; hence, STING activation is expected to induce IFN-I response and adipocyte dysfunction. …”
Publicado 2023
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159por Sun, Chuanchuan, Shi, Heng, Zhao, Xinhai, Chang, Yu-Ling, Wang, Xianghong, Zhu, Shiping, Sun, Shengyun“…The activation of the cGAS-STING pathway is associated with many sterile inflammatory and inflammatory conditions, including acute kidney injury. …”
Publicado 2023
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160por Izquierdo, José M.Enlace del recurso
Publicado 2023
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