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  1. 316061
    “…We aimed to describe trends in absolute and relative COVID-19-related mortality risks across clinical and demographic population subgroups during successive SARS-CoV-2 pandemic waves. METHODS: We did a retrospective cohort study in England using the OpenSAFELY platform with the approval of National Health Service England, covering the first five SARS-CoV-2 pandemic waves (wave one [wild-type] from March 23 to May 30, 2020; wave two [alpha (B.1.1.7)] from Sept 7, 2020, to April 24, 2021; wave three [delta (B.1.617.2)] from May 28 to Dec 14, 2021; wave four [omicron (B.1.1.529)] from Dec 15, 2021, to April 29, 2022; and wave five [omicron] from June 24 to Aug 3, 2022). …”
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    Changes in COVID-19-related mortality across key demographic and clinical subgroups in England from 2020 to 2022: a retrospective cohort study using the OpenSAFELY platform
  2. 316062
    “…AUTHORS' CONCLUSIONS: There is high‐certainty evidence that using combination NRT versus single‐form NRT and 4 mg versus 2 mg nicotine gum can result in an increase in the chances of successfully stopping smoking. Due to imprecision, evidence was of moderate certainty for patch dose comparisons. …”
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    Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation
  3. 316063
    “…Further study that includes larger sample sizes, confirmation of successful gene transfer to meniscal cells around the tear site, and investigations of both later time points of wound healing and the mechanisms by which local TGF-β1 gene therapy may modulate augmented meniscus healing in this rat model of meniscal defect is necessary to better determine the potential future clinical utility of local TGF-β1 gene therapy to treat of meniscus tears with poor healing capacity.…”
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    Poster 136: Augmented Meniscus Radial Tear Healing via Local Transforming Growth Factor-beta 1 (TGF- β1) Gene Therapy in a Rat Model
  4. 316064
    “…Three bilateral patients were unable to be matched, resulting in a 21:42 match with respective bilateral and unilateral cohorts having a mean age (22.5 ± 5.7 vs 23.3 ± 6.6 years; p = 0.65), sex (males 9/21 vs 18/42; p = 1.00), BMI (25.87 ± 6.39 vs 25.21 ± 4.78 kg/m(2); p = 0.65), and concomitant TTO (9/18 vs 18/42; p = 1.00) that did not significantly differ, indicating successful matching. When comparing matched cohorts, bilateral MPFLR patients returned-to-sport at a similar rate to unilaterals following both their first (61.1% vs 63.2%; p = 0.98) and second MPFLR (72.7% vs 63.2%; p = 0.82). …”
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    Poster 251: Patients who Undergo Bilateral Medial Patellofemoral Ligament Reconstruction Return to Sport at a Similar Rate to Unilaterals: A Matched Cohort Study
  5. 316065
    “…OBJECTIVES: There has been an increased focus on the significance of meniscal extrusion in medial meniscal root repairs, as meniscal extrusion is often still present following a successful medial meniscal root repair. If the meniscus is extruded, the function of the meniscus as a shock absorber and secondary knee stabilizer can be compromised. …”
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    Poster 134: Biomechanical Analysis of Meniscotibial Ligament Tenodesis to Treat Meniscal Extrusion in the Setting of Posterior Medial Meniscal Root Repair
  6. 316066
    “…Further follow-up is required to determine the success of this program over the longer term in promoting quality of care and achieving cost reductions and improved health outcomes.…”
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    Evaluation of a Program to Improve Diabetes Care Through Intensified Care Management Activities and Diabetes Medication Copayment Reduction
  7. 316067
    “…The clinical course of scleromyxoedma is usually chronic and progressive, with variable success of therapies including IVIG, cyclophosphamide, methotrexate and thalidomide. …”
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    P22 Will the real scleroderma please stand up?: a case of a rare scleroderma mimic in ED
  8. 316068
    por Rajeswaran, Thurkka, Mackie, Sarah
    Publicado 2023
    “…All three of these actions needed to occur simultaneously for the plan to be successful. On trying to unpick what “feeling-safe” came down to, we felt it largely boiled down to effective communication between all parties involved, as well having the access to appropriate care. …”
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    OA04 Muscle weakness in chronic rheumatic diseases: the need for early diagnosis and tailored exercise programme
  9. 316069
    “…In addition, HE staining and oil red O staining showed obvious AS plaque formation in the vessel wall, and a large amount of fat deposition in VSMC, thus indicating that the hyperhomocysteinemia As an animal model was successfully established. Furthermore, CTRP9 were downregulated, while GRP78, p-PERK, ATF6a, p-IRE1α, SREBP1c, SREBP2 was upregulated in aortic VSMC in the ApoE(−/−) + HMD group. …”
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    Hypermethylation of the CTRP9 promoter region promotes Hcy induced VSMC lipid deposition and foam cell formation via negatively regulating ER stress
  10. 316070
    “…A "ZLJT-compound-target-disease" network was successfully constructed using Cytoscape 3.7.0. GO enrichment analysis revealed that ZLJT mainly affected biological processes such as adenylate cyclase-modulating G protein-coupled receptor. …”
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    A real-world study and network pharmacology analysis of EGFR-TKIs combined with ZLJT to delay drug resistance in advanced lung adenocarcinoma
  11. 316071
    “…Penicillin is FDA approved for NVTs and was the most often used drug (44/53). The successful use of azithromycin in some cases (7) indicates its potential as a second-line agent if resistance to penicillin arises. …”
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    1382. The Lesser Known Treponemal Infections: A Review Of Non-Syphilitic Cases
  12. 316072
    por Duval, Charles W., Gurd, Eraser B.
    Publicado 1911
    “…In this manner, we have been successful in the production of lesions in the monkey, goat, horse, guinea pig, and mouse. …”
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    EXPERIMENTAL IMMUNITY WITH REFERENCE TO THE BACILLUS OF LEPROSY : PART I. A STUDY OF THE FACTORS DETERMINING INFECTION IN ANIMALS.
  13. 316073
    por Winternitz, M. C., Kline, B. S.
    Publicado 1915
    “…—A normal rabbit that has been previously benzolized, and in this way deprived of its myeloid elements, can not be successfully immunized. Here the immune serum injected even in excessive quantities is followed by the immediate reaction, but the ultimate result is entirely different, —the animal dies. …”
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    STUDIES UPON EXPERIMENTAL PNEUMONIA IN RABBITS : IX. THE PART OF THE LEUCOCYTE IN THE IMMUNITY REACTION.
  14. 316074
    por Zinsser, Hans, Parker, Julia T.
    Publicado 1917
    “…This we eliminate as negative evidence inasmuch as we believe that the toxic substances need at no given time be present in the blood stream in sufficient concentration to render such an experiment successful. They are probably absorbed and do their injury almost as rapidly as formed, an assumption which is based on the speed with which symptoms develop. …”
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    STUDIES ON BACTERIAL ANAPHYLAXIS AND INFECTION
  15. 316075
    por Noguchi, Hideyo
    Publicado 1920
    “…Monovalent immune sera prepared by several successive injections in an animal naturally refractory to Leptospira icteroides possess the power to agglutinate in vitro not only the homologous strains, but also all other strains of icteroides tested. …”
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    ETIOLOGY OF YELLOW FEVER : X. COMPARATIVE IMMUNOLOGICAL STUDIES ON LEPTOSPIRA ICTEROIDES AND LEPTOSPIRA ICTEROHÆMOORRHAGIÆ.
  16. 316076
    “…Back school programs, which in addition to theoretical instructions offer intensive exercising may in the short term, be successful in reducing the incidence of new episodes of back pain. …”
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    Prevention of relapsing backache
  17. 316077
    por Kones, Richard
    Publicado 2011
    “…Given the current obstacles, success of primordial prevention remains uncertain. …”
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    Primary prevention of coronary heart disease: integration of new data, evolving views, revised goals, and role of rosuvastatin in management. A comprehensive survey
  18. 316078
    “…WHAT IS KNOWN AND WHAT THIS PAPER ADDS: HB sperm demonstrate enhanced developmental parameters which have been associated with successful fertilization and embryogenesis. Sperm selected for ICSI using a liquid source of hyaluronan achieved an improvement in IR. …”
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    Use of hyaluronan in the selection of sperm for intracytoplasmic sperm injection (ICSI): significant improvement in clinical outcomes—multicenter, double-blinded and randomized controlled trial
  19. 316079
    “…Such markers may reflect and/or be a proxy for the core biology of suicide. We were successful in this endeavor, using a comprehensive stepwise approach, leading to a wealth of findings. …”
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    Precision medicine for suicidality: from universality to subtypes and personalization
  20. 316080
    “…The OA QI (UK) supports the NICE quality standards for OA and they have been successfully used to assess the quality of OA consultations in primary care in the MOSAICS study. …”
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    Patient-reported quality indicators for osteoarthritis: a patient and public generated self-report measure for primary care
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