“…Blockade of P(2X) and NPY(1) receptors with suramin (0.5 mM) and BIBP3226 (1.0 µM) respectively, reduced tone by a further 22%, leaving 16% of basal tone unaffected at these concentrations of antagonists. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Sensitivity to the antagonists NF449, suramin, and PPADS was conferred by the nature of the extracellular loop (e.g. nanomolar for NF449 at P2X1 and P2X2-1EXT and micromolar at P2X2 and P2X1-2EXT). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The [Ca(2+)](i) oscillations were sensitive also to P2-receptor inhibition by suramin. Taken together, these data confirm that mechanosensitive Cx30 hemichannels mediate tubular ATP release and purinergic calcium signaling in the CD which mechanism plays an important role in the regulation of CD salt and water reabsorption.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Secondly, we demonstrate pharmacological stimulation of sympathetic nerves in situ (by tyramine) evokes pericyte-mediated vasoconstriction of vasa recta capillaries; inhibited by the application of the P2 receptor antagonist suramin. Lastly, tyramine-evoked vasoconstriction of vasa recta by pericytes is significantly less than ATP-evoked vasoconstriction. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, β-catenin-regulated transcriptional (CRT) activity is significantly inhibited by casein kinase II inhibitor DRB, MEK inhibitor PD98059, G-proteins and their receptor uncoupling agent suramin, protein tyrosine kinase inhibitor genistein, and PI-3 kinase inhibitor wortmannin, suggesting that these cellular pathways may participate in regulating β-catenin signaling. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…UTP incubation resulted in unchanged Na,K-ATPase activity in humans, but pre-incubation with the antagonist suramin resulted in inhibition with UTP, suggesting that P2Y receptors are involved. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Indiscriminate blockade of the P2 purinergic receptors with suramin abrogated rucaparib-induced vasodilation in rat arterial tissue without affecting ML-9-evoked dilation, although the specific receptor subtypes responsible have not been unequivocally identified. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These responses were not altered by the cyclooxygenase inhibitor, indomethacin (5 μM), the vasoactive intestinal polypeptide receptor antagonist, [(d)-p-Cl-Phe6,Leu17]-vasoactive intestinal peptide (PheLeu-VIP; 100 nM), or the purinoceptor antagonists, 8-phenyltheophyline (P1 receptors) or suramin (P2 receptors). However, relaxation responses were reduced by Nω-nitro-L-arginine (L-NNA; 100 μM), an inhibitor of nitric oxide synthesis (40–50% reduction), zinc protoprophyrin IX (10 μM), an inhibitor of carbon monoxide synthesis (20–40% reduction), and also propargylglycine (30 μM) and aminooxyacetic acid (30 μM), inhibitors of hydrogen sulphide synthesis (15–20% reduction). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These effects were blocked by suramin. Interestingly, the anti-oxidant agent superoxide dismutase (SOD) blocked TGF-β1 induced proliferation and collagen gel contraction without modulating the gene expression of α-SMA, collagen type I, TGF-β1, TGF-β R1 and TGF-β R2. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…There are several synthetic derivatives of the natural agonist ATP and some structurally-complex antagonists including compounds such as PPADS, NTP-ATP, suramin and its derivatives (e.g. NF279, NF449). NF449 is the most potent and selective ligand, but potencies of many others are not particularly high and they can also act at other P2X, P2Y and non-purinergic receptors. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In CII-treated dendritic cells (DCs) and DC/CD4(+) T coculture system, pretreatment with pharmacological antagonists of P2X7R (Suramin and A-438079) caused strong inhibition of production of Th17-promoting cytokines (IL-1β, TGF-β1, IL-23p19 and IL-6). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Inhibition of purinergic signaling by treating retina explants with either apyrase, a nucleotide-hydrolyzing enzyme, or suramin, a broad spectrum antagonist of purinergic receptors, significantly prevents the entry of microglial cells into the retina. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Apyrase (ATP/ADP-hydrolyzing enzyme), suramin (broad-spectrum P2 receptor antagonist), 2-APB (IP(3) receptor blocker) and thapsigargin (endoplasmic reticulum calcium pump inhibitor) potently inhibited these ICWs, respectively, indicating the dependence of nucleotide signals and P2Y receptors. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A virtual screening of commercially available drug-like compounds (~300,000) was performed on the suramin and PPNDS binding-sites of the norovirus RNA-dependent RNA polymerase (RdRp). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Apyrase, an ATP-degrading enzyme, and suramin, a non-selective P2 purinergic receptor antagonist, did not exert inhibitory effects on these [Ca(2+)](i) increases in the TGs following MC stimulation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Importantly, SCD1 and SLCO2A1 have been previously shown to be potently and selectively inhibited by compounds such as CAY10566 and suramin, respectively. We also uncovered cancer-selective metabolic liabilities in central carbon, amino acid, and lipid metabolism. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Walrycin B (IC(50) = 0.26 μM), Hydroxocobalamin (IC(50) = 3.29 μM), Suramin sodium (IC(50) = 6.5 μM), Z-DEVD-FMK (IC(50) = 6.81 μM), LLL-12 (IC(50) = 9.84 μM), and Z-FA-FMK (IC(50) = 11.39 μM) are the most potent 3CL(pro) inhibitors. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Walrycin B (IC(50) = 0.26 μM), hydroxocobalamin (IC(50) = 3.29 μM), suramin sodium (IC(50) = 6.5 μM), Z-DEVD-FMK (IC(50) = 6.81 μM), LLL-12 (IC(50) = 9.84 μM), and Z-FA-FMK (IC(50) = 11.39 μM) are the most potent 3CL(pro) inhibitors. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…UTP-induced responses were near completely inhibited by the P2Y(2) receptor antagonists, suramin and AR-C118925. P2Y(2) receptor-mediated Ca(2+) mobilization was inhibited by U-73122 and 2-aminoethoxydiphenyl borate (2-APB), indicating P2Y(2) receptor coupling to the phospholipase C and inositol triphosphate signal transduction pathway. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Results: Of the proposed inhibitors, chebulinic acid, CD-437 and suramin are the most potent with IC(50)-values in the low micromolar range, whereas another six are effective at a concentration of 100 μM. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso