Mostrando 21 - 40 Resultados de 326 Para Buscar '"Suramin"', tiempo de consulta: 0.15s Limitar resultados
  1. 21
    “…Introduced about a century ago, suramin remains a frontline drug for the management of early-stage East African trypanosomiasis (sleeping sickness). …”
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    Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes
  2. 22
    “…In addition, L. donovani infected BALB/c mice were administered suramin and a host of immunological parameters determined to estimate the antileishmanial potency of the drug. …”
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    In vivo experiments demonstrate the potent antileishmanial efficacy of repurposed suramin in visceral leishmaniasis
  3. 23
    “…Electron microscopy shows that Suramin inhibits the formation in vitro of RNP complex-like condensates by SARS-CoV-2 N with a synthetic ssRNA. …”
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    Suramin inhibits SARS-CoV-2 nucleocapsid phosphoprotein genome packaging function
  4. 24
    “…Suramin is a polypharmacological molecule that inhibits diverse proteins. …”
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    Suramin action in African trypanosomes involves a RuvB-like DNA helicase
  5. 25
    “…Suramin is an antitrypanosomal agent with antineoplastic activity, but with serious systemic side effects. …”
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    Phase I trial of intravesical Suramin in recurrent superficial transitional cell bladder carcinoma
  6. 26
    “…BACKGROUND: Epidural fibrosis often causes serious complications in patients after lumbar laminectomy and discectomy and is associated with the proliferation of fibroblasts. Suramin is known to have an obvious inhibitory effect on the coactions of many growth factors and their receptors, but little was previously known about the effect of suramin on fibroblast proliferation and the progress of epidural fibrosis. …”
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    The effect of suramin on inhibiting fibroblast proliferation and preventing epidural fibrosis after laminectomy in rats
  7. 27
    “…The anti-parasitic drug suramin was previously shown to inhibit CHIKV replication. …”
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    Suramin Inhibits Chikungunya Virus Replication by Interacting with Virions and Blocking the Early Steps of Infection
  8. 28
    “…Treatment of neurospheres with suramin induced a significant increase in neurosphere diameter and in NPC number attributed to a decrease in apoptosis. …”
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    Purinergic Receptor Blockade with Suramin Increases Survival of Postnatal Neural Progenitor Cells In Vitro
  9. 29
    “…The rats received suramin 7 and 14 days after a single STZ injection (65 mg/kg, ip). …”
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    Suramin enhances the urinary excretion of VEGF-A in normoglycemic and streptozotocin-induced diabetic rats
  10. 30
    “…However, effective treatment options for IDD are limited. Suramin is used to treat African sleeping sickness. …”
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    Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway
  11. 31
    “…Whether suramin could have a therapeutic effect on ADPKD has not been fully investigated. …”
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    Effects of Suramin on Polycystic Kidney Disease in a Mouse Model of Polycystin-1 Deficiency
  12. 32
    “…Suramin in diabetes restored acetylcholine relaxation properties to non-diabetic levels. …”
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    Suramin Affects the Renal VEGF-A/VEGFR Axis in Short-Term Streptozotocin-Induced Diabetes
  13. 33
    “…PURPOSE: Suramin is a multifunctional molecule with a wide range of potential applications, including parasitic and viral diseases, as well as cancer. …”
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    Phase I, Single-Dose Study to Assess the Pharmacokinetics and Safety of Suramin in Healthy Chinese Volunteers
  14. 34
    “…The study had 3 treatment arms: 10 mg/kg suramin, 20 mg/kg suramin, and placebo given at baseline, week 4, and week 8. …”
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    Randomized clinical trial of low dose suramin intravenous infusions for treatment of autism spectrum disorder
  15. 35
    “…The polyanionic compound suramin can inhibit the proliferation of cells of various origin, including from breast cancer. …”
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    Effects of suramin on cell-cycle kinetics of MCF-7 human breast cancer cells in vitro.
  16. 36
    “…The effects of suramin, an inhibitor of growth factor mitogenic activity, were evaluated on basic fibroblast growth factor (bFGF)-induced proliferation of bovine aortic endothelial cells and on angiogenesis in the chorioallantoic membrane (CAM) of chick embryos. …”
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    Suramin inhibits bFGF-induced endothelial cell proliferation and angiogenesis in the chick chorioallantoic membrane.
  17. 37
    “…Suramin was able to reduce tumour growth and tumour induced angiogenesis, and exogenous administration of bFGF countered suramin effects. …”
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    Suramin prevents neovascularisation and tumour growth through blocking of basic fibroblast growth factor activity.
  18. 38
    “…Several drug examples for their hormetic effects in vivo were listed as resveratrol, suramin, and tamoxifen. The action of suramin in the present study could be evaluated as one of the hormetic examples of suramin in vivo.…”
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    Suramin Increased Telomerase Activity in the C6 Glioma/Wistar Experimental Brain Tumor Model
  19. 39
    “…We previously identified Suramin (9) as a potent inhibitor of NV-RNA dependent RNA polymerase (NV-RdRp). …”
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    Structural Bases of Norovirus RNA Dependent RNA Polymerase Inhibition by Novel Suramin-Related Compounds
  20. 40
    “…Suramin was initially used to treat African sleeping sickness and has been clinically tested to treat human cancers and HIV infection in the recent years. …”
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    Suramin Targets the Conserved Ligand-Binding Pocket of Human Raf1 Kinase Inhibitory Protein
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