Mostrando 41 - 60 Resultados de 326 Para Buscar '"Suramin"', tiempo de consulta: 0.50s Limitar resultados
  1. 41
    “…Only three drugs were identified as inhibitors of MAYV: β-D-N(4)-hydroxycytidine (EIDD-1931), favipiravir and suramin. The in vitro anti-MAYV activity of these antiviral compounds was further confirmed in a virus yield assay. …”
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    Repurposing Drugs for Mayaro Virus: Identification of EIDD-1931, Favipiravir and Suramin as Mayaro Virus Inhibitors
  2. 42
    “…Suramin was originally used as an antiparasitic drug in clinics. …”
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    Suramin Disturbs the Association of the N-Terminal Domain of SARS-CoV-2 Nucleocapsid Protein with RNA
  3. 43
    “…Suramin is thus a promising scaffold for the development of novel therapeutics to increase TIMP-3 levels and inhibit cartilage degradation in osteoarthritis.…”
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    Suramin Inhibits Osteoarthritic Cartilage Degradation by Increasing Extracellular Levels of Chondroprotective Tissue Inhibitor of Metalloproteinases 3
  4. 44
    “…Binding of suramin analogues to Mcm10 was confirmed by surface plasmon resonance (SPR). …”
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    The anti-parasitic agent suramin and several of its analogues are inhibitors of the DNA binding protein Mcm10
  5. 45
    por El-Kordy, Eman Ali
    Publicado 2019
    “…Group I served as a control, group II received suramin alone (10 mg/kg). Groups III, IV and V were administered cisplatin once (5 mg/kg, intraperitoneally) alone or combined with low dosage suramin (5 mg/kg) or high dosage suramin (10 mg/kg) once intravenously respectively. …”
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    Effect of Suramin on Renal Proximal Tubular Cells Damage Induced by Cisplatin in Rats (Histological and Immunohistochemical Study)
  6. 46
    “…Thus, these novel suramin derivatives may be considered superior anti-metastasis molecules than those of suramin.…”
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    Synthesis of Novel Suramin Analogs With Anti-Proliferative Activity via FGF1 and FGFRD2 Blockade
  7. 47
    “…Since suramin reduces both enzyme-dependent and enzyme-independent effects of the toxins, suramin is not acting as a simple enzyme inhibitor. …”
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    Suramin inhibits the early effects of PLA(2) neurotoxins at mouse neuromuscular junctions: A twitch tension study
  8. 48
    “…Interest has recently been focused on the potential therapeutic effect of mouse adult renal progenitor cells (MRPC), erythropoietin (EPO) and suramin in the recovery of ischemia-induced AKI. The aim of the present study is to compare MRPC with MRPC/EPO or MRPC/suramin concomitantly in the treatment of a mouse model of ischemia/reperfusion (I/R) AKI. …”
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    Improving outcomes of acute kidney injury using mouse renal progenitor cells alone or in combination with erythropoietin or suramin
  9. 49
    “…The Suramin Autism Treatment‐1 (SAT‐1) trial was a double‐blind, placebo‐controlled, translational pilot study to examine the safety and activity of low‐dose suramin in children with ASD. …”
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    Low‐dose suramin in autism spectrum disorder: a small, phase I/II, randomized clinical trial
  10. 50
    “…This work reports the in vitro antileishmanial activity for the aminoglycoside netilmicin (for some Leishmania parasites) and the anti-trypanosomatid suramin. Synergism was also observed between paromomycin–suramin and netilmicin–curcumin. …”
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    In vitro screening of known drugs identified by scaffold hopping techniques shows promising leishmanicidal activity for suramin and netilmicin
  11. 51
    “…In a primary human airway epithelial cell culture model, suramin also inhibited the progression of infection. …”
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    Suramin Inhibits SARS-CoV-2 Infection in Cell Culture by Interfering with Early Steps of the Replication Cycle
  12. 52
    “…In the present study, we developed a novel suramin fragment and deoxycholic acid conjugate (SFD) that exhibited the potential to bind to the heparin-binding site (HBD) of vascular endothelial growth factor (VEGF) and to inhibit its pathogenic action for the first time. …”
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    Molecular Targeting of VEGF with a Suramin Fragment–DOCA Conjugate by Mimicking the Action of Low Molecular Weight Heparins
  13. 53
    “…Surface plasmon resonance (SPR) experiments demonstrated that quinacrine and suramin alone possessed a moderate or weak affinity with SARS-CoV-2 3CL(pro) but suramin binding increased quinacrine interaction by around a factor of eight. …”
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    The Repurposed Drugs Suramin and Quinacrine Cooperatively Inhibit SARS-CoV-2 3CL(pro) In Vitro
  14. 54
    “…Although neither ATP nor suramin affected NLRP3 expression in MMCs, suramin inhibited ATP‐induced NLRP3 complex formation and the downstream expression of caspase‐1 and IL‐18 in MMCs. …”
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    Suramin prevents the development of diabetic kidney disease by inhibiting NLRP3 inflammasome activation in KK‐Ay mice
  15. 55
    “…A short-term exposure to suramin 300 micrograms ml-1 produced a modest reduction in 3H-thymidine incorporation but suppressed the mitogenic effect of bFGF on V79/AP4 cells. …”
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    Involvement of basic fibroblast growth factor in suramin-induced inhibition of V79/AP4 fibroblast cell proliferation.
  16. 56
    “…Suramin was introduced into the clinic a century ago and is still used to treat the first stage of acute human sleeping sickness. …”
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    Expression of a specific variant surface glycoprotein has a major impact on suramin sensitivity and endocytosis in Trypanosoma brucei
  17. 57
    “…However, compounds with two bridging aromatic groups were 5- to 10-fold less toxic than suramin in mice, suggesting a potential for an improved therapeutic ratio. …”
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    A structure-activity analysis of antagonism of the growth factor and angiogenic activity of basic fibroblast growth factor by suramin and related polyanions.
  18. 58
    por Wang, Pei-Rong
    Publicado 2013
    “…Experimental evidence has indicated a role of adult renal progenitor cells in kidney regeneration and a protective role of the kidney by erythropoietin (EPO) and suramin in animal models and in humans after acute kidney injury (AKI). …”
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    Mouse adult renal progenitor cells in combination with erythropoietin or suramin - a potential new strategy for the treatment of acute kidney injury
  19. 59
    “…OBJECTIVES: Suramin is an old drug used for the treatment of African sleeping sickness. …”
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    Suramin increases cartilage proteoglycan accumulation in vitro and protects against joint damage triggered by papain injection in mouse knees in vivo
  20. 60
    “…The crystal structure of the MjTX-I/suramin showed a totally different interaction mode compared to other PLA(2)-like/suramin complexes. …”
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    Structural and functional characterization of suramin-bound MjTX-I from Bothrops moojeni suggests a particular myotoxic mechanism
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