Mostrando 61 - 80 Resultados de 326 Para Buscar '"Suramin"', tiempo de consulta: 0.13s Limitar resultados
  1. 61
    “…The cyclin A2 and cyclin B1 mRNAs were destabilized by suramin. Furthermore, the motile and invasive activities of a tongue carcinoma cell line treated with suramin were markedly lower than those of control cells. …”
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    Suramin, screened from an approved drug library, inhibits HuR functions and attenuates malignant phenotype of oral cancer cells
  2. 62
    “…This study aimed to investigate the effect of suramin on chondrocyte differentiation and its underlying mechanism. …”
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    Suramin enhances chondrogenic properties by regulating the p67(phox)/PI3K/AKT/SOX9 signalling pathway
  3. 63
    “…Suramin was previously shown to bind to the EV-A71 capsid through its naphthalenetrisulfonic acid groups, thereby reducing virus-cell binding and inhibiting viral replication. …”
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    Suramin interacts with the positively charged region surrounding the 5-fold axis of the EV-A71 capsid and inhibits multiple enterovirus A
  4. 64
    “…Suramin (Sur) acts as an ecto-NTPDase inhibitor in Trypanosoma cruzi and a P2-purinoceptor antagonist in mammalian cells. …”
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    Purinergic Antagonist Suramin Aggravates Myocarditis and Increases Mortality by Enhancing Parasitism, Inflammation, and Reactive Tissue Damage in Trypanosoma cruzi-Infected Mice
  5. 65
    “…In vitro bacterial tests showed that when CM15⋅suramin complex formation dominates over membrane binding, antimicrobial activity is abolished. …”
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    Manipulating Active Structure and Function of Cationic Antimicrobial Peptide CM15 with the Polysulfonated Drug Suramin: A Step Closer to in Vivo Complexity
  6. 66
    “…Suramin treatment failures has been observed among HAT patients in Tbr foci in Uganda. …”
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    Physiological and proteomic profiles of Trypanosoma brucei rhodesiense parasite isolated from suramin responsive and non-responsive HAT patients in Busoga, Uganda
  7. 67
    “…Specifically, heparan sulfate and suramin had enhanced preferential binding for Omicron RBD, and suramin is most potent against the live SARS-CoV-2 Omicron variant (B.1.1.529) when compared to wild type and Delta (B.1.617.2) variants in vitro. …”
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    Suramin binds and inhibits infection of SARS-CoV-2 through both spike protein-heparan sulfate and ACE2 receptor interactions
  8. 68
    “…Suramin has long been used in the treatment of various human diseases. …”
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    The effects of Suramin on Ca(2+) activated force and sarcoplasmic reticulum Ca(2+) release in skinned fast‐twitch skeletal muscle fibers of the rat
  9. 69
    “…NF449, a sulfated compound derived from the antiparasitic drug suramin, was previously reported to inhibit infection by enterovirus A71 (EV-A71). …”
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    The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate
  10. 70
    “…Suramin precluded interaction of RdRp with RNA and even displaced RdRp from RNA.…”
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    Surface plasmon resonance approach to study drug interactions with SARS-CoV-2 RNA-dependent RNA polymerase highlights treatment potential of suramin
  11. 71
    “…We studied the growth characteristics and hypoxic fractions of DLD-2 human colon tumours xenografted into male nude mice either in the unperturbed state or after i.p. injection (q.i.d. x 7) of basic fibroblast growth factor (0.25 mg kg-1) or suramin (50 mg kg-1). Hypoxic fractions were measured by clonogenic excision assay 1 day after administration b FGF or suramin was stopped. …”
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    Modification of the volumetric growth responses and steady-state hypoxic fractions of xenografted DLD-2 human colon carcinomas by administration of basic fibroblast growth factor or suramin.
  12. 72
    por El-Ajouz, S, Ray, D, Allsopp, RC, Evans, RJ
    Publicado 2012
    “…These chimeras and mutations were also involved in determining sensitivity to the antagonist suramin. Reciprocal chimeras and mutations in the P2X2 receptor produced modest increases in antagonist sensitivity. …”
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    Molecular basis of selective antagonism of the P2X1 receptor for ATP by NF449 and suramin: contribution of basic amino acids in the cysteine-rich loop
  13. 73
    Publicado 1989
    “…Treatment of the transformed transfected NIH 3T3 cells with suramin, which blocks the interaction of bFGF with its receptor, reversed the morphological transformation and restored receptors almost to normal numbers. …”
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    Transformation of NIH 3T3 cells with basic fibroblast growth factor or the hst/K-fgf oncogene causes downregulation of the fibroblast growth factor receptor: reversal of morphological transformation and restoration of receptor number by suramin
  14. 74
    “…However, ISG75 null cells present only modest attenuation of suramin sensitivity, have unaltered viability in vivo and in vitro and no alteration to suramin-invoked proteome responses. …”
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    The role of invariant surface glycoprotein 75 in xenobiotic acquisition by African trypanosomes
  15. 75
    “…These data show good uptake of suramin into the central nervous system at the level of the brainstem. …”
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    Reversal of autism-like behaviors and metabolism in adult mice with single-dose antipurinergic therapy
  16. 76
    “…Furthermore, our results suggest that HMGA2 may be one of suramin’s cellular targets.…”
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    Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays
  17. 77
    por Taylor, John M., Han, Ziying
    Publicado 2010
    “…This study began with evidence that suramin, a symmetrical hexasulfated napthylurea, could block HDV entry into primary human hepatocytes (PHH) and was then extrapolated to incorporate findings of others that suramin is one of many compounds that can block activation of purinergic receptors. …”
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    Purinergic Receptor Functionality Is Necessary for Infection of Human Hepatocytes by Hepatitis Delta Virus and Hepatitis B Virus
  18. 78
    “…Commercially available suramin analogs also show antiviral effects against HAdV-D37. …”
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    Decoy Receptor Interactions as Novel Drug Targets against EKC-Causing Human Adenovirus
  19. 79
    “…Moreover, we have compared NhPV with another compound, Suramin, for their anti-SARS-CoV-2 activities and the mode of their actions, and found that both NhPV and Suramin are able to directly interrupt SCoV-2–SP binding to its receptor ACE2 and block the viral entry step. …”
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    Identification and evaluation of the inhibitory effect of Prunella vulgaris extract on SARS-coronavirus 2 virus entry
  20. 80
    “…Suramin (100μM) blocked the NO response to acute hypoxia by 53%. …”
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    Increased Endogenous Nitric Oxide Release by Iron Chelation and Purinergic Activation in the Rat Carotid Body
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