Mostrando 81 - 100 Resultados de 326 Para Buscar '"Suramin"', tiempo de consulta: 0.08s Limitar resultados
  1. 81
    “…Expression of a proposed suramin transporter, located in T. brucei lysosomes, in T. congolense, did not alter its suramin sensitivity. …”
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    Differences in Transporters Rather than Drug Targets Are the Principal Determinants of the Different Innate Sensitivities of Trypanosoma congolense and Trypanozoon Subgenus Trypanosomes to Diamidines and Melaminophenyl Arsenicals
  2. 82
    “…TER reduction was observed in suramin-treated IPEC-J2 cell monolayers, which could be attributed to cell cytotoxic properties of 48 hr 50 μM suramin administration. …”
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    Reinforced Epithelial Barrier Integrity via Matriptase Induction with Sphingosine-1-Phosphate Did Not Result in Disturbances in Physiological Redox Status
  3. 83
    por Steverding, Dietmar
    Publicado 2010
    “…Only four drugs are available for the chemotherapy of human African trypanosomiasis or sleeping sickness; Suramin, pentamidine, melarsoprol and eflornithine. …”
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    The development of drugs for treatment of sleeping sickness: a historical review
  4. 84
    “…Validation confirmed that the best hit, suramin, inhibits the RNA binding ability of SND1. …”
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    Inhibition of RNA Binding in SND1 Increases the Levels of miR-1-3p and Sensitizes Cancer Cells to Navitoclax
  5. 85
    “…Suramin and Cav3.2/USP5 Tat-disruptor peptides were also tested in models of diabetic neuropathy and visceral pain, and provided remarkable protection. …”
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    Small organic molecule disruptors of Cav3.2 - USP5 interactions reverse inflammatory and neuropathic pain
  6. 86
    “…Using a multidisciplinary approach we report herein that the approved drug suramin acts as a non-competitive in vitro inhibitor of the hPIV-3 haemagglutinin-neuraminidase (HN). …”
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    A dual drug regimen synergistically blocks human parainfluenza virus infection
  7. 87
    “…Heparanase (HPSE), a heparan sulfate-specific endo-β-D-glucuronidase, plays an important role in tumor cell metastasis through the degradation of extracellular matrix heparan sulfate proteoglycans. Suramin, a polysulfonated naphthylurea, is an inhibitor of HPSE with suramin analogues. …”
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    The close relationship between heparanase and epithelial mesenchymal transition in gastric signet-ring cell adenocarcinoma
  8. 88
    “…Thus, the study concludes that suramin might be helpful as a potential inhibitor against RNA-dependent RNA polymerase of SRAS-CoV-2. …”
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    In silico identification of promising inhibitor against RNA-dependent RNA polymerase target of SARS-CoV-2
  9. 89
    “…Our study showed that suramin, an inhibitor of PTP1B, could improve neuronal damage. …”
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    Therapeutic Role of Protein Tyrosine Phosphatase 1B in Parkinson's Disease via Antineuroinflammation and Neuroprotection In Vitro and In Vivo
  10. 90
    “…However, the suramin- and PPADS-insensitive receptor activated by UTP and UDP does not correspond to any of the known P2Y subtypes. …”
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    Multiple P2Y receptors couple to calcium-dependent, chloride channels in smooth muscle cells of the rat pulmonary artery
  11. 91
    “…Pre-treatment with the P2R antagonist suramin significantly reduced the expression and release of MUC5AC. …”
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    Extracellular ATP is involved in dsRNA-induced MUC5AC production via P2Y2R in human airway epithelium
  12. 92
    “…Stx induced the release of toxin-positive HeLa cell- and platelet-derived microvesicles, detected by flow cytometry, an effect significantly reduced by NF449 or suramin. Suramin decreased microvesicle levels in mice injected with Stx or inoculated with Stx-producing EHEC. …”
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    Shiga toxin signals via ATP and its effect is blocked by purinergic receptor antagonism
  13. 93
    “…The structure of the L–VP35–suramin complex reveals that suramin can bind at the highly conserved NTP entry channel to prevent substrates from entering the active site. …”
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    Structure of the Ebola virus polymerase complex
  14. 94
    “…Finally, we reveal that the drug suramin, by virtue of its structural similarities, is an inhibitor of DNA-dependent inflammation and propose that suramin could be rapidly repurposed to meet an increasing clinical need.…”
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    Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome
  15. 95
    “…Eflornithine crossed the healthy blood–CNS interfaces poorly, but this could be improved by co-administering suramin, but not nifurtimox, pentamidine or melarsoprol. …”
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    The blood–brain barrier significantly limits eflornithine entry into Trypanosoma brucei brucei infected mouse brain(1)
  16. 96
    “…Pretreatment of C.roseus cells with variety of agents such as suramin, N-acetyl cysteine, and inhibitors of calcium fluxes and protein kinases and MAP kinase prevented this effect of UV-B irriadiation. …”
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    UV-B induced transcript accumulation of DAHP synthase in suspension-cultured Catharanthus roseus cells
  17. 97
    “…In addition, ovalbumin (OVA) challenge induced neutrophilic inflammation and Th17 polarization in DO11.10 mice, whereas administration of suramin before challenge alleviated these parameters. …”
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    Adenosine Triphosphate Promotes Allergen-Induced Airway Inflammation and Th17 Cell Polarization in Neutrophilic Asthma
  18. 98
    “…Naphthalene polysulfonated compounds (NPS) such as suramin have previously been explored as antibiotic adjuvants targeting RecA, although the underlying structural bases for RecA-ligand interactions remain obscure. …”
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    Structural insights into the inhibition of bacterial RecA by naphthalene polysulfonated compounds
  19. 99
    Publicado 1993
    “…NIH 3T3 cells transformed by the signal/anchor-sis constructs exhibited morphological reversion upon treatment with suramin, indicating a requirement for ligand/receptor interactions in a suramin- sensitive compartment, most likely the cell surface. …”
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    The v-sis protein retains biological activity as a type II membrane protein when anchored by various signal-anchor domains, including the hydrophobic domain of the bovine papilloma virus E5 oncoprotein
  20. 100
    “…Blocking of purinergic signalling with suramin inhibited BSMC expression of IL-33 induced by dsRNA and BEC-derived medium. …”
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    Rhinoviral stimuli, epithelial factors and ATP signalling contribute to bronchial smooth muscle production of IL-33
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