Mostrando 121 - 140 Resultados de 326 Para Buscar '"Suramin"', tiempo de consulta: 0.18s Limitar resultados
  1. 121
    por Chakraborty, Sandeep
    Publicado 2016
    “…The conformational changes in the suramin molecule on binding highlights the challenges in docking flexible ligands into an already ’plastic’ binding site. …”
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    DOCLASP - Docking ligands to target proteins using spatial and electrostatic congruence extracted from a known holoenzyme and applying simple geometrical transformations
  2. 122
    “…In agreement with this in vitro observation, pretreatment with apyrase or suramin suppressed the high IVP‐induced urothelial ERK activation in vivo. …”
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    Intravital imaging of mouse urothelium reveals activation of extracellular signal‐regulated kinase by stretch‐induced intravesical release of ATP
  3. 123
    “…In present study, four-month-old APP/PS1 mice were administered resveratrol (RSV) or suramin once daily for two months, following which their spatial learning and memory were assessed using the Morris water maze test. …”
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    The neuroprotective effects of SIRT1 in mice carrying the APP/PS1 double-transgenic mutation and in SH-SY5Y cells over-expressing human APP670/671 may involve elevated levels of α7 nicotinic acetylcholine receptors
  4. 124
    por Ullah, Anwar, Ullah, Kifayat
    Publicado 2021
    “…The global binding energy of Suramin, 2S albumin, and flocculating proteins were −41.96, −9.12, and −14.78 kJ/mol, respectively. …”
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    Inhibition of SARS-CoV-2 3CL M(pro) by Natural and Synthetic Inhibitors: Potential Implication for Vaccine Production Against COVID-19
  5. 125
    “…These changes of both cells at 3 dpi were mostly decayed at 7 dpi and were suppressed by any of IL-10, IL-4, suramin (P2 receptor inhibitor) and 4-AP (K(+) channel blocker). …”
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    Roles of Cytokines in the Temporal Changes of Microglial Membrane Currents and Neuronal Excitability and Synaptic Efficacy in ATP-Induced Cortical Injury Model
  6. 126
    “…In addition, treatment of C. elegans wild-type N2 and the oga-1 mutant with PUGNAc + suramin and suramin (an ubiquitination inhibitor), respectively has resulted in increased sensitivity to S. aureus infection. …”
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    O-GlcNAcylation confers protection against Staphylococcus aureus infection in Caenorhabditis elegans through ubiquitination
  7. 127
    “…This depressant effect was antagonized by CPZ and suramin, but not by the P(2)X antagonist, 2', 3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP). …”
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    Depression of presynaptic excitation by the activation of vanilloid receptor 1 in the rat spinal dorsal horn revealed by optical imaging
  8. 128
    “…A 7-min OGD induced tissue anoxic depolarization and was invariably followed by irreversible loss of fEPSP. PPADS, suramin, MRS2179 or BBG (brilliant blue G) significantly prevented the irreversible failure of neurotransmission induced by 7-min OGD. …”
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    Role of P2 purinergic receptors in synaptic transmission under normoxic and ischaemic conditions in the CA1 region of rat hippocampal slices
  9. 129
    por Sharma, Bechan
    Publicado 2011
    “…The sensitivity of PFK from S. cervi towards antifilarials/anthelmintics was comparatively higher than that of mammalian PFK. With suramin, the Ki value for rat liver PFK was 40 times higher than PFK from S. cervi. …”
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    Modulation of phosphofructokinase (PFK) from Setaria cervi, a bovine filarial parasite, by different effectors and its interaction with some antifilarials
  10. 130
    “…The extracellular H+ fluxes induced by ATP were mimicked by the P2Y1 agonist MRS 2365 and were significantly reduced by the P2 receptor blockers suramin and PPADS, suggesting activation of P2Y receptors. …”
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    Activation of retinal glial (Müller) cells by extracellular ATP induces pronounced increases in extracellular H+ flux
  11. 131
    “…The binding of s-adenosyl-L-methionine was examined along with the competitive binding of adenine, dATP, and suramin. Based on fluorescence spectroscopy experiments the dissociation constant for the four ligands and the target protein could be determined; SAM (1.4 ± 0.7 µM), adenine (17.8 ± 1.5 µM), dATP (15.8 ± 2.0 µM), and Suramin (6.3 ± 1.1 µM). …”
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    Binding studies of a putative C. pseudotuberculosis target protein from Vitamin B(12) Metabolism
  12. 132
    por Cruz, Ana Miguel, Beall, Craig
    Publicado 2020
    “…Acute and chronic treatment with ATPγS increased glycolytic rate in a manner that was differentially inhibited by PPADs and suramin, suggesting heterogeneous P2R activation in the control of cellular metabolism. …”
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    Extracellular ATP Increases Glucose Metabolism in Skeletal Muscle Cells in a P2 Receptor Dependent Manner but Does Not Contribute to Palmitate-Induced Insulin Resistance
  13. 133
    “…Results showed that, in general, hydrophobic drugs, such as remdesivir and sofosbuvir, bind better to both binding sites than relatively less hydrophobic drugs, such as alovudine, molnupiravir, zidovudine, favilavir, and ribavirin. However, suramin, which is a highly hydrophobic drug, unexpectedly showed overall weaker binding affinities in both binding sites when compared to other drugs. …”
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    The Unusual Architecture of RNA-Dependent RNA Polymerase (RdRp)’s Catalytic Chamber Provides a Potential Strategy for Combination Therapy against COVID-19
  14. 134
    “…The ineffectiveness of suramin at the concentration used was consistent with P2Y(4 )but not P2Y(2). …”
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    Apical membrane P2Y4 purinergic receptor controls K(+ )secretion by strial marginal cell epithelium
  15. 135
    “…At non-toxic concentrations, all significantly inhibited invasion (P< 0.05), although to varying degrees, suramin and Å5 almost completely and N-acetylcysteine the least. …”
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    Human bladder cancer invasion model using rat bladder in vitro and its use to test mechanisms and therapeutic inhibitors of invasion
  16. 136
    “…On the other hand, ATPγS stimulated Jak2 and STAT3 activation which were inhibited by pretreatment with PPADS, suramin, Gö6983, Gö6976, Ro318220, GF109203X, Rottlerin, Edaravone, DPI, and apocynin in A549 cells. …”
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    ATP Mediates NADPH Oxidase/ROS Generation and COX-2/PGE(2) Expression in A549 Cells: Role of P2 Receptor-Dependent STAT3 Activation
  17. 137
    “…Furthermore, our simulations predict that suramin may interfere ligand binding on P(2)Y(2) receptors or accelerate P(2)Y(2) receptor phosphorylation, which may partially be the reason for Ca(2+) wave attenuation by suramin. …”
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    Computational Model of Ca(2+) Wave Propagation in Human Retinal Pigment Epithelial ARPE-19 Cells
  18. 138
    “…Despite relapsing 6 weeks after completing amphotericin B therapy, the patient made a complete recovery after 5 weeks of suramin. The patient was found to have 2 wild-type APOL1 alleles and a normal serum APOL1 concentration. …”
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    A Clinical and Epidemiological Investigation of the First Reported Human Infection With the Zoonotic Parasite Trypanosoma evansi in Southeast Asia
  19. 139
    “…The effects of the P2 receptor antagonists suramin and PPADS, the P2Y(14) receptor antagonist PPTN, and the P2Y(6) receptor antagonist MRS2578, were investigated. …”
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    UDP-sugars activate P2Y(14) receptors to mediate vasoconstriction of the porcine coronary artery
  20. 140
    “…The propagation distance was decreased when the purinergic receptor antagonists pyridoxalphosphate‐6‐azophenyl‐2′,4′‐disulfonic acid (PPADS; 50 μm) or suramin (150 μm) were added to the extracellular buffer. …”
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    Intercellular Ca(2+) signalling in the adult mouse cochlea
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