Mostrando 1 - 20 Resultados de 326 Para Buscar '"Suramin"', tiempo de consulta: 0.57s Limitar resultados
  1. 1
    “…CONCLUSIONS: Delayed administration of a single dose of suramin in a model of T2DN attenuated inflammation and fibrosis as well as improved renal function, supporting the use of suramin in T2DN.…”
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    Suramin: A Potential Therapy for Diabetic Nephropathy
  2. 2
    “…Numerous studies have reported the broad antiviral activities of suramin; however, inhibition effects against CHIKV have not yet been demonstrated. …”
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    Suramin Inhibits Chikungunya Virus Entry and Transmission
  3. 3
    “…On the second week after surgery, rats were randomly divided into suramin treatment and non-treatment groups. Suramin was given at 10 mg/kg once per week for two weeks. …”
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    Suramin Alleviates Glomerular Injury and Inflammation in the Remnant Kidney
  4. 4
    “…Suramin also interfered with Hsp104 disaggregase, unfoldase, and translocase activities, and the inhibitory effect of Suramin was not rescued by Hsp70 and Hsp40. …”
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    Suramin Inhibits Hsp104 ATPase and Disaggregase Activity
  5. 5
    Publicado 2014
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    Correction: Suramin: A Potential Therapy for Diabetic Nephropathy
  6. 6
    “…Suramin is a trypan blue analogon originally developed to treat protozoan infections, which was found to have diverse antitumor effects. …”
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    Suramin-Induced Neurotoxicity: Preclinical Models and Neuroprotective Strategies
  7. 7
    “…METHODS: In the rat model of peritoneal fibrosis induced by CG, suramin or saline was administered at day 21 and 28. …”
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    Delayed administration of suramin attenuates peritoneal fibrosis in rats
  8. 8
    por De Clercq, Erik
    Publicado 2021
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    1984—Discovery of the First Anti-HIV Drug, Suramin
  9. 9
    “…Using a multidisciplinary approach, we found that the approved pediatric antiparasitic drug suramin blocked EV71 infectivity by a novel mechanism of action that involves binding of the naphtalentrisulonic acid group of suramin to the viral capsid. …”
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    The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection—suramin inhibits EV71 infection in vitro and in vivo
  10. 10
    por Choe, G., Kim, W. H., Park, J. G., Kim, Y. I.
    Publicado 1997
    “…The amount of CEA released by a cell was increased in suramin-containing culture. Suramin inhibited heterotransplantation, and a transplant from suramin-containing culture revealed a much higher degree of differentiation than that from suramin-absent culture. …”
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    Effect of suramin on differentiation of human stomach cancer cell lines.
  11. 11
    “…We found that suramin inhibited RTK and ERK1/2 phosphorylation in cultured human PA-SMCs. …”
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    The Beneficial Effect of Suramin on Monocrotaline-Induced Pulmonary Hypertension in Rats
  12. 12
    “…Suramin has been a primary early-stage treatment for African trypanosomiasis for nearly one hundred years. …”
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    Structure of Trypanosome Coat Protein VSGsur and Function in Suramin Resistance
  13. 13
    “…Tau:suramin condensates do not seed Tau aggregation in a HEK cell model for Tau aggregation, even after extended incubation. …”
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    Initiation and modulation of Tau protein phase separation by the drug suramin
  14. 14
    “…In CCA and RMZ-RC2 cells suramin was able to induce a significant increase (up to 3-fold) in the proportion of myosin-positive cells over control cultures. …”
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    Redundancy of autocrine loops in human rhabdomyosarcoma cells: induction of differentiation by suramin.
  15. 15
    “…Suramin had little effect on the mouse receptor. Suramin and NF449 are polysulfonates, with six and eight negative charges, respectively. …”
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    Ectodomain Lysines and Suramin Block of P2X(1) Receptors
  16. 16
    “…As a competitive inhibitor of heparin, suramin has been described to have anti-viral activity. …”
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    Suramin is a potent inhibitor of Chikungunya and Ebola virus cell entry
  17. 17
    “…With virtual-screening docking simulations on a library of pharmacologically active compounds, we identified suramin as a potential NF-Y inhibitor. We focused on suramin given its high water-solubility that is an important factor for in vitro testing, since NF-Y is sensitive to DMSO. …”
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    Structural Basis of Inhibition of the Pioneer Transcription Factor NF-Y by Suramin
  18. 18
    “…In the present study, we evaluated the long-term (11 weeks) effects of suramin (10 mg/kg, i.p., once-weekly) in diabetic rats. …”
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    Long-Term Effects of Suramin on Renal Function in Streptozotocin-Induced Diabetes in Rats
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    “…Phosphorothioate oligonucleotides and suramin bind to heparin binding proteins including DNA polymerases, and inhibit their functions. …”
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    Phosphorothioate oligonucleotides, suramin and heparin inhibit DNA-dependent protein kinase activity
  20. 20
    “…We have therefore tested whether the growth inhibiting effect of suramin on ovarian and cervical cancer cells is due to downregulation of Hpa expression. …”
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    Suramin inhibits cell proliferation in ovarian and cervical cancer by downregulating heparanase expression
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