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  1. 18501
    “…Due to strong clinical suspicion and family history of thyroid dysfunction that never needed a treatment, we tested her genetically for familial dysalbumineic hyperthyroxinemia (FDH) using mutation surveyor and fluorescent sequence analysis showed her to be heterozygous for c.725G>A ALB variant confirming diagnosis of FDH. …”
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    MON-480 Isolated Hyperthyroxinemia - Does Everyone Needs Treatment?
  2. 18502
    por Jamal, Issra
    Publicado 2020
    “…Conclusion: POEMS syndrome is a rare condition that involves multiple endocrine organs, currently there are no guidelines or recommendations to obtain baseline endocrine labs once the diagnosis is confirmed, but it might be appropriate if there is a high clinical suspicion. References: 1. Castillo JJ (2016). “Plasma Cell Disorders”. …”
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    SAT-LB117 POEMS Syndrome: Rare Presentation of New Onset Diabetes Mellitus
  3. 18503
    “…Conclusion: This case demonstrates the potential for chronic opioid use to suppress the hypothalamic-pituitary-thyroid axis and highlights the importance of maintaining an index of suspicion for hypothyroidism in this population. Reference: (1) de Vries, F., Bruin, M., Lobatto, DJ., Dekkers, OM., Schoones, JW., van Furth, WR., Pereira, AM., Karavitaki, N., Biermasz, NR., Najafabadi, AHZ. …”
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    SAT-LB45 Chronic Opioid Use as a Cause of Severe Hypothyroidism: A Case Report
  4. 18504
    por Ghanta, Neelima, Adams, Derick
    Publicado 2020
    “…Conclusion: Although a rare disorder, clinicians should have a high index of suspicion for PHP to prevent complications of hypocalcemia (tetany, arrhythmias, seizures) and metabolic bone disease from PTH resistance. …”
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    SAT-371 Severe Hypocalcemia Secondary to Pseudohypoparathyroidism
  5. 18505
    “…Conclusion: A high clinical index of suspicion is required for TIO in the setting of phosphaturic osteomalacia, particularly with a normal serum FGF23. …”
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    SAT-385 A Normal FGF23 Does Not Preclude Tumor Induced Osteomalacia (TIO)
  6. 18506
    por Salameh, Rami, Prater, Janna
    Publicado 2020
    “…Elevated 11-Deoxycortisol level raised a suspicion for 11-OHD CAH, or adrenal vs ovarian hormone-producing mass. …”
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    SUN-204 Case of Non-Classic Congenital Adrenal Hyperplasia with Compound CYP21A2 Mutations Combined with CYP11B1 Mutation
  7. 18507
    “…Unlike PHP type 1A, PHP1B often presents later in life and features of AHO are usually absent, so diagnosis requires a high degree of clinical suspicion. It is recommended that patients with suspected PHP have molecular confirmation with sequencing, methylation, and/or copy number variant analysis of GNAS. …”
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    SAT-343 Diagnosis and Management of Pseudohypoparathyroidism Type 1B
  8. 18508
    “…GnRH (100 μg i.v) stimulation test showed a supranormal basal FSH level and a normal to higher LH response (FSH at baseline/peak were 23.0/38.6 IU/L; LH at baseline/peak were 8.81/47.7 IU/L). Under the clinical suspicion of aromatase deficiency, we performed genetic sequencing of CYP19A1 (NM_031226) and found a homozygous missense variant c.1108G>A (V370M), a previously reported pathogenic mutation. …”
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    SUN-033 A Rare Case: Bone Pain and Continued Linear Growth in a Young Adult Male Due to Aromatase Deficiency
  9. 18509
    “…In cases with strong suspicion of FHH despite negative CASR and AP2S1 analyses, genetic analysis of GNA11 should also be considered. …”
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    SAT-340 Familial Hypocalciuric Hypercalcemia Due to a C.571G>A (p.Glu191Lys) Variant in the GNA11 Gene
  10. 18510
    “…CONCLUSION MODY remains underdiagnosed. A high index of suspicion should be maintained in nonobese, DAA-negative patients diagnosed with DM before 25yo. …”
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    MON-057 MODY Diagnosis: Missed Opportunity to Avert Insulin Therapy. A Case Series
  11. 18511
    “…On April 1st of 2019, with suspicion of neuroleptic malignant syndrome, the patient was transferred to ICU at our institution. …”
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    S216. CASE REPORT OF TREATMENT OF NEUROLEPTIC MALIGNANT SYNDROME IN CHILD ADOLESCENT
  12. 18512
    “…Duplex ultrasonography should be reserved for patients with a high clinical suspicion of venous thromboembolism for whom anticoagulation therapy could result in life-threatening consequences. …”
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    Deep vein thrombosis in hospitalized patients with coronavirus disease 2019
  13. 18513
    “…Findings of complicated appendicitis on radiographic imaging including suspicion of perforation (41.7% vs 9.8%, p < 0.001) and intra-abdominal abscess (27.1% vs 7.3%, p = 0.025) were higher in patients presenting in 2020. …”
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    Delayed presentation and sub-optimal outcomes of pediatric patients with acute appendicitis during the COVID-19 pandemic
  14. 18514
    “…Seizures were defined as clinical events with a high-degree of suspicion to be true seizures, and were entirely comprised of generalized tonic-clonic seizures. …”
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    346. Eastern Equine Encephalitis and Use of Intravenous Immunoglobulin Therapy and High-Dose Steroids
  15. 18515
    “…Both imaging tests were reported on a validated 5-point scale of suspicion. If any test result was positive, a systematic 12-core biopsy was performed. …”
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    Population-Based Prostate Cancer Screening With Magnetic Resonance Imaging or Ultrasonography: The IP1-PROSTAGRAM Study
  16. 18516
    por Martínez-Gamboa, Areli, Niembro-Ortega, María Dolores, Torres-González, Pedro, Santiago-Cruz, Janeth, Velázquez-Zavala, Nancy Guadalupe, Rangel-Cordero, Andrea, Crabtree-Ramírez, Brenda, Gamboa-Domínguez, Armando, Reyes-Gutiérrez, Edgardo, Reyes-Terán, Gustavo, Lozano-Fernandez, Víctor Hugo, Ahumada-Topete, Víctor Hugo, Martínez-Ayala, Pedro, Manríquez-Reyes, Marisol, Ramírez-Hinojosa, Juan Pablo, Rodríguez-Zulueta, Patricia, Hernández-León, Christian, Ruíz-Quiñones, Jesús, Rivera-Martínez, Norma Eréndira, Chaparro-Sánchez, Alberto, Andrade-Villanueva, Jaime, González-Hernández, Luz Alicia, Cruz-Martínez, Sofia, Flores-Barrientos, Oscar, Gaytán-Martínez, Jesús Enrique, Magaña-Aquino, Martín, Cervantes-Sánchez, Axel, Olivas-Martínez, Antonio, Araujo-Meléndez, Javier, del Rocío Reyes-Montes, María, Duarte-Escalante, Esperanza, Frías-De León, María Guadalupe, Ramírez, José Antonio, Taylor, María Lucia, de León-Garduño, Alfredo Ponce, Sifuentes-Osornio, José
    Publicado 2021
    “…METHODOLOGY/PRINCIPAL FINDINGS: We included 415 PLWHIV older than 18 years of age with suspicion of PDH. Using as diagnostic standard recovery of H. capsulatum in blood, bone marrow or tissue cultures, or histopathological exam compatible, detected 108 patients (26%, [95%CI, 21.78–30.22]) with proven-PDH. …”
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    Diagnostic accuracy of antigen detection in urine and molecular assays testing in different clinical samples for the diagnosis of progressive disseminated histoplasmosis in patients living with HIV/AIDS: A prospective multicenter study in Mexico
  17. 18517
    “…Conclusions: This is the first reported case of hepatocellular carcinoma in a patient with MEN 2A syndrome who had no predisposing liver disease, raising suspicion that his germline RET mutation contributed to his liver cancer.…”
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    Occurrence of Hepatocellular Carcinoma in a 40-Year-Old Male With MEN2A Syndrome
  18. 18518
    “…Serum IgG4 level was found to be elevated to 142 mg/dl (range: 1–123) which raised suspicion for autoimmune cholangiopathy. Discussion: Patient presented with non-PTH mediated hypercalcemia with low serum 1,25 OHD levels and elevated serum PTHrP level. …”
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    Prednisone-Responsive Hypercalcemia in a Patient With IgG4 Disease and Elevated Serum PTHrP Levels
  19. 18519
    “…It is important to consider hyperthyroidism in the differential diagnoses of severe hypercalcemia. Prompt suspicion is essential due to the effective treatments available for Graves’ disease. …”
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    Graves’ Disease Induced Severe Hypercalcemia
  20. 18520
    por Akinseye, Leah I
    Publicado 2021
    “…Since autoantibody status/titer may not always predict the clinical course, it is important for clinicians to keep a high index of suspicion of this process when the clinical course is atypical. …”
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    Oscillating Hypo-Hyperthyroidism; a Rare Type of Autoimmune Thyroiditis in Adolescence
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