“…Children aged 4 years were classified as having suspected ASD if they did not meet the case definition for ASD but had a documented qualified professional’s statement indicating a suspicion of ASD. This report focuses on children aged 4 years in 2020 compared with children aged 8 years in 2020. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Nonetheless, clinical suspicion was sufficient for the patient to have echocardiography which indicated new onset PAH. …”
Enlace del recurso
Enlace del recurso

“…The lack of response to anti-microbials and elevated ferritin raised suspicion of autoinflammatory pathology and prompted inpatient transfer to a tertiary rheumatology service.  …”
Enlace del recurso
Enlace del recurso

“…This article was inspired by the following: A) Nesse's “Smoke-Detector Principle”, B) the increasing suspicion that the “smooth” rather than “lumpy” distribution of complex psychiatric phenotypes (including fear-circuitry disorders) may in some cases be accounted for by oligogenic (and not necessarily polygenic) transmission, and C) insights from the initial sequence of the chimpanzee genome and comparison with the human genome by the Chimpanzee Sequencing and Analysis Consortium published in late 2005. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…TRIAL DESIGN: Randomised, parallel arm, open-label, adaptive platform Phase 2/3 trial of potential disease modifying therapies in patients with late stage 1/stage 2 COVID-19-related disease, with a diagnosis based either on a positive assay or high suspicion of COVID-19 infection by clinical, laboratory and radiological assessment. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Fever (>38 C) within the past 24 hours. Suspicion of active viral or bacterial infection. Pregnancy. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CASE REPORT - DISCUSSION: The presence of the combination of a petechial/purpuric rash on her lower limbs, worsening fatigue and Raynaud’s, and symptoms consistent with a progressive peripheral neuropathy raised the suspicion of a vasculitic process in this patient, which warranted urgent investigation. …”
Enlace del recurso
Enlace del recurso

“…Inclusion criteria: - Signed informed consent - Age 18-85 years - Evidence of pulmonary involvement on CT scan or X-ray of the chest - Duration of symptoms associated with COVID-19 ≤ 10 days - At least one of the following risk factors for progression to mechanical ventilation on the day of enrolment: 1) Arterial hypertension 2) ≥ 50 years 3) Obesity (BMI ≥ 30 kg/m2) 4) History of cardiovascular disease 5) Chronic pulmonary disease 6) Chronic renal disease 7) C-reactive protein > 35mg/L 8) Oxygen saturation at rest of ≤ 94% when breathing ambient air Exclusion criteria: - Incapacity or inability to provide informed consent - Contraindications to the class of drugs under investigation (C1 esterase inhibitor) - Treatment with tocilizumab or another IL-6R or IL-6 inhibitor before enrolment - History or suspicion of allergy to rabbits - Pregnancy or breast feeding - Active or anticipated treatment with any other complement inhibitor - Liver cirrhosis (any Child-Pugh score) - Admission to an ICU on the day or anticipated within the next 24 hours of enrolment - Invasive or non-invasive ventilation - Participation in another study with any investigational drug within the 30 days prior to enrolment - Enrolment of the study investigators, their family members, employees and other closely related or dependent persons INTERVENTION AND COMPARATOR: Patients randomized to the experimental arm will receive conestat alfa in addition to standard of care (SOC). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Consequently, its diagnosis often relies on clinical suspicion and pattern recognition. Typical Cogan’s syndrome refers to the appearance of ocular and vestibuloauditory symptoms within 2 years of each other. …”
Enlace del recurso
Enlace del recurso

“…Nevertheless, a low threshold of suspicion should be maintained. Based on uncertainties in the evidence, current expert consensus is to avoid anti-TNF agents in patients with current malignancy or any prior melanoma, and to exercise caution with a history of malignancy in the last 5 years. …”
Enlace del recurso
Enlace del recurso

“…This makes it a great tool for the global assessment of disease activity, the specific inflammatory phenotypes in psoriatic arthritis, and avert anatomical damage and physical functional disability. When there is a suspicion of loss of efficacy from a biological agent, and hesitancy to change the biologic (due to cost and restrictions on access), ultrasonography could help add weight to decision making when considering changing a biologic agent. …”
Enlace del recurso
Enlace del recurso

“…This raises the possibility of a relationship between MIS-C and low vitamin D levels, as Vitamin D is known to be involved in immune modulation.(1,4) CONCLUSION: A high index of suspicion of MIS-C is required in children with COVID exposure with otherwise typical presentation of common paediatric emergency ailments. …”
Enlace del recurso
Enlace del recurso

“…Après une semaine d’amélioration, l’oxygénothérapie était réaugmentée à 6 L/min. Devant la suspicion d’autres complications, des traitements tels que furosémide ou terbutaline ont été essayés sans efficacité. …”
Enlace del recurso
Enlace del recurso

“…Documented sepsis or high suspicion of superimposed infection by pathogens other than COVID-19. f. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The simultaneously active inflammatory disease at the time and recurrent thrombosis whilst on clopidogrel adds suspicion of a vasculopathic component. All cases were anti-phospholipid negative. …”
Enlace del recurso
Enlace del recurso

“…Exclusion criteria are: 1) allergy or contraindication to any of the drugs under study; 2) oxygen saturation (SpO(2)) <90% (in air ambient) or partial pressure of oxygen in arterial blood (PaO(2)) <60 mmHg (in ambient air) or PaO(2)/FiO(2) <300 mmHg; 3) ongoing treatment with glucocorticoids, or other immunosuppressants, including biologics for another indication; 4) decompensated diabetes mellitus; 5) uncontrolled hypertension; 6) psychotic or manic disorder; 7) active cancer; 8) pregnancy or breastfeeding; 9) clinical or biochemical suspicion (procalcitonin >0.5 ng/mL) of active infection other than with SARS-CoV-2; 10) management as an outpatient; 11) conservative or palliative management; 12) participation in another clinical trial; or 13) any major uncontrolled medical, psychological, psychiatric, geographic or social problem that contraindicates the patient's participation in the trial or hinders proper follow-up and adherence to the protocol and evaluation of study outcomes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Only confirmed cases or those with high level of suspicion were collected. Denominators regarding affected cohort (% tested, % affected in CML population) were not available in most instances. …”
Enlace del recurso
Enlace del recurso

“…RESULTS: Key recommendations and suggestions, listed by category, include: early quantitative resuscitation of the septic patient during the first 6 h after recognition (1C); blood cultures before antibiotic therapy (1C); imaging studies performed promptly to confirm a potential source of infection (UG); administration of broad-spectrum antimicrobials therapy within 1 h of the recognition of septic shock (1B) and severe sepsis without septic shock (1C) as the goal of therapy; reassessment of antimicrobial therapy daily for de-escalation, when appropriate (1B); infection source control with attention to the balance of risks and benefits of the chosen method within 12 h of diagnosis (1C); initial fluid resuscitation with crystalloid (1B) and consideration of the addition of albumin in patients who continue to require substantial amounts of crystalloid to maintain adequate mean arterial pressure (2C) and the avoidance of hetastarch formulations (1B); initial fluid challenge in patients with sepsis-induced tissue hypoperfusion and suspicion of hypovolemia to achieve a minimum of 30 mL/kg of crystalloids (more rapid administration and greater amounts of fluid may be needed in some patients (1C); fluid challenge technique continued as long as hemodynamic improvement is based on either dynamic or static variables (UG); norepinephrine as the first-choice vasopressor to maintain mean arterial pressure ≥65 mmHg (1B); epinephrine when an additional agent is needed to maintain adequate blood pressure (2B); vasopressin (0.03 U/min) can be added to norepinephrine to either raise mean arterial pressure to target or to decrease norepinephrine dose but should not be used as the initial vasopressor (UG); dopamine is not recommended except in highly selected circumstances (2C); dobutamine infusion administered or added to vasopressor in the presence of (a) myocardial dysfunction as suggested by elevated cardiac filling pressures and low cardiac output, or (b) ongoing signs of hypoperfusion despite achieving adequate intravascular volume and adequate mean arterial pressure (1C); avoiding use of intravenous hydrocortisone in adult septic shock patients if adequate fluid resuscitation and vasopressor therapy are able to restore hemodynamic stability (2C); hemoglobin target of 7–9 g/dL in the absence of tissue hypoperfusion, ischemic coronary artery disease, or acute hemorrhage (1B); low tidal volume (1A) and limitation of inspiratory plateau pressure (1B) for acute respiratory distress syndrome (ARDS); application of at least a minimal amount of positive end-expiratory pressure (PEEP) in ARDS (1B); higher rather than lower level of PEEP for patients with sepsis-induced moderate or severe ARDS (2C); recruitment maneuvers in sepsis patients with severe refractory hypoxemia due to ARDS (2C); prone positioning in sepsis-induced ARDS patients with a Pao (2)/Fio (2) ratio of ≤100 mm Hg in facilities that have experience with such practices (2C); head-of-bed elevation in mechanically ventilated patients unless contraindicated (1B); a conservative fluid strategy for patients with established ARDS who do not have evidence of tissue hypoperfusion (1C); protocols for weaning and sedation (1A); minimizing use of either intermittent bolus sedation or continuous infusion sedation targeting specific titration endpoints (1B); avoidance of neuromuscular blockers if possible in the septic patient without ARDS (1C); a short course of neuromuscular blocker (no longer than 48 h) for patients with early ARDS and a Pao (2)/Fi o (2) <150 mm Hg (2C); a protocolized approach to blood glucose management commencing insulin dosing when two consecutive blood glucose levels are >180 mg/dL, targeting an upper blood glucose ≤180 mg/dL (1A); equivalency of continuous veno-venous hemofiltration or intermittent hemodialysis (2B); prophylaxis for deep vein thrombosis (1B); use of stress ulcer prophylaxis to prevent upper gastrointestinal bleeding in patients with bleeding risk factors (1B); oral or enteral (if necessary) feedings, as tolerated, rather than either complete fasting or provision of only intravenous glucose within the first 48 h after a diagnosis of severe sepsis/septic shock (2C); and addressing goals of care, including treatment plans and end-of-life planning (as appropriate) (1B), as early as feasible, but within 72 h of intensive care unit admission (2C). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Antibiotics will be individualized based on clinical suspicion, including the management of febrile neutropenia. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The current qualitative study addresses this gap by following up the original 2014 sample to examining the nature of children’s suspicions using thematic analysis. By giving voice to children and adolescents, I will discuss: 1) children’s definition of trust and mistrust more broadly 2) the common themes generated from interview questions about children’s suspicions in relation to baseline self-reported levels of suspiciousness on the Social Mistrust Scale (SMS) and 3) other developmental psychosocial factors contributing to childhood suspicions. …”
Enlace del recurso
Enlace del recurso