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Mostrando 321 - 340 Resultados de 1,074 Para Buscar '"TDT"', tiempo de consulta: 0.21s Limitar resultados
  1. 321
    “…Twenty-one participants (19.8%) were prenatally diagnosed with thalassemia, with a median age of 8 years (IQR 9.00), 16 were diagnosed with transfusion-dependence thalassemia (TDT), and 5 participants were diagnosed with non-TDT. …”
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    Prenatal Diagnosis Leads to Early Diagnosis of Transfusion-Dependent Thalassemia and Better Growth Outcomes
  2. 322
    “…Finally, the nsPEF protocols were successfully applied for the stable transfection of the CHO-K1 cell line with the linearized pcDNA3.1(+)/Luc2 = tdT plasmid. The results of the study are applicable in gene therapy and DNA vaccination studies for the derivation of optimal electrotransfection conditions.…”
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    Transfection by Electroporation of Cancer and Primary Cells Using Nanosecond and Microsecond Electric Fields
  3. 323
    “…Results from the ECLIPSE study, an open-label, randomized, multicenter, 2-arm, phase 2 study evaluated the safety of deferasirox dispersible tablet and film-coated tablet (FCT) formulations in patients with transfusion-dependent thalassemia (TDT) or very low, low, or intermediate risk myelodysplastic syndrome (MDS) treated over 24 weeks. …”
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    Two-year long safety and efficacy of deferasirox film-coated tablets in patients with thalassemia or lower/intermediate risk MDS: phase 3 results from a subset of patients previously treated with deferasirox in the ECLIPSE study
  4. 324
    “…Thalidomide induces γ-globin expression in erythroid progenitor cells, but its efficacy on patients with transfusion-dependent β-thalassemia (TDT) remains unclear. In this phase 2, multi-center, randomized, double-blind clinical trial, we aimed to determine the safety and efficacy of thalidomide in TDT patients. …”
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    Safety and efficacy of thalidomide in patients with transfusion-dependent β-thalassemia: a randomized clinical trial
  5. 325
    “…Similarly, Osx(+) and DMP1(+) lineage cells and their progeny significantly contributed to endochondral callus regions with continuous dosing only, with higher TdT(+) chondrocyte fraction in Osx(+) versus DMP1(+) cell lineages. …”
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    Postnatal Osterix but not DMP1 lineage cells significantly contribute to intramembranous ossification in three preclinical models of bone injury
  6. 326
    “…Background The increased risk of infections in transfusion-dependent β-thalassemia major (TDT) patients is mainly due to underlying immune dysfunction; however, its cause is largely unidentified. …”
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    Correlation of T-regulatory Cells and Iron Status in β-Thalassemia Major Patients
  7. 327
    “…DT was ranged from 7.7 to 28 s; while TDT was from 26.4 to 77.6 s. Both polymer and plasticizer concentrations were found to be influencing the characteristics of the strips. …”
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    Fabrication of polyvinyl alcohol based fast dissolving oral strips of sumatriptan succinate and metoclopramide HCL
  8. 328
    “…The patient had a history of transfusion-dependent thalassemia (TDT) and secondary hemochromatosis with the latest serum ferritin ranging from 8000 to 15,000. …”
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    Severe iron overload cardiomyopathy manifested as acute myopericarditis: A case report
  9. 329
    “…Furthermore, the optimized formulations showed a DT of 13 ± 1 s and TDT of 42.6 ± 0.75 s, indicating prompt disintegration as well as the dissolution of the films. …”
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    Statistically Optimized Polymeric Buccal Films of Eletriptan Hydrobromide and Itopride Hydrochloride: An In Vivo Pharmacokinetic Study
  10. 330
    Publicado 1993
    “…We find that expression of terminal deoxynucleotidyl transferase (TdT), lambda 5, and VpreB is predominantly restricted to the Pro-B stages. …”
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    The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver
  11. 331
    “…As a test exhibiting this feature to its maximum, we introduce the multimarker [Image: see text] -Groups TDT ( [Image: see text] ), a test which under the hypothesis of no linkage, asymptotically follows a [Image: see text] distribution with [Image: see text] degree of freedom regardless the number of markers. …”
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    Sample Reproducibility of Genetic Association Using Different Multimarker TDTs in Genome-Wide Association Studies: Characterization and a New Approach
  12. 332
    “…Although the family-based TDT indicated a meaningful association for rs3821949 (P = 0.028), the haplotype analysis did not reveal any significant association with rs3821949, rs12532, or rs4464513. …”
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    Association between MSX1 SNPs and Nonsyndromic Cleft Lip with or without Cleft Palate in the Korean Population
  13. 333
    “…A multi-point parametric linkage analysis localized the blindness phenotype to a ~1.75 Mb region with significant LOD scores (Z ≈ 14, θ = 0.00) on cat chromosome E1. Genome-wide TDT, sib-TDT, and case–control analyses also consistently supported significant association within the same region on chromosome E1, which is homologous to human chromosome 17. …”
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    Genome-wide association and linkage analyses localize a progressive retinal atrophy locus in Persian cats
  14. 334
    “…We trained eight AMD and five JMD patients to perform a texture-discrimination task (TDT) at their preferred retinal locus (PRL) used for fixation. …”
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    Perceptual learning in patients with macular degeneration
  15. 335
    “…We evaluate the proposed methods through non-centrality parameter calculations and simulation studies and compare them to the previously proposed approaches, parenTDT and combTDT. We show that incorporation of parental phenotype data often improves statistical power. …”
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    Using parental phenotypes in case-parent studies
  16. 336
    “…The temporal discrimination threshold (TDT) is the shortest time interval at which two sensory stimuli presented sequentially are detected as asynchronous by the observer. …”
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    Young Women do it Better: Sexual Dimorphism in Temporal Discrimination
  17. 337
    “…METHODS: To evaluate relationships between TDT and survival, we retrospectively evaluated 231 patients who underwent surgical resection for non-small cell lung cancer. …”
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    Solid component tumor doubling time is a prognostic factor in non-small cell lung cancer patients
  18. 338
    “…RESULTS: Psychomotor recovery assessed by TDT showed statistically significant early recovery in group D compared with group S. …”
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    Time course of psychomotor recovery after intravenous dexmedetomidine infusion as a part of balanced anaesthetic technique: A randomised, double-blind study
  19. 339
    “…The prevalence of HCC in thalassemia major patients [characterized by transfusion-dependency (TDT)] and thalassemia intermedia [characterized by nontransfusion dependency (NTDT)] was 1.66 % and 1.96 %, respectively. …”
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    A Concise Review on the Frequency, Major Risk Factors and Surveillance of Hepatocellular Carcinoma (HCC) in β-Thalassemias: Past, Present and Future Perspectives and the ICET-A Experience
  20. 340
    “…Here we found that, unlike postnatal γδ thymocytes, human fetal γδ thymocytes were functionally programmed (e.g., IFNγ, granzymes) and expressed low levels of terminal deoxynucleotidyl transferase (TdT). This low level of TdT resulted in a low number of N nucleotide insertions in the complementarity-determining region-3 (CDR3) of their TCR repertoire, allowing the usage of short homology repeats within the germline-encoded VDJ segments to generate invariant/public cytomegalovirus-reactive CDR3 sequences (TRGV8-TRJP1-CATWDTTGWFKIF, TRDV2-TRDD3-CACDTGGY, and TRDV1-TRDD3-CALGELGD). …”
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    The human fetal thymus generates invariant effector γδ T cells
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