“…Terminal deoxynucleotidyltransferase (TdT) is a member of the DNA polymerase X family that is responsible for random addition of nucleotides to single-stranded DNA. …”
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“…CD19(+)CD10(+) human B lineage bone marrow cells were separated into cycling or resting cells, which differ in their expression of CD34, V(preB), recombination activating gene (RAG-1), and terminal deoxynucleotidyl transferase (TdT). Polymerase chain reaction analyses developed for D(H)J(H) and V(κ)J(κ), V(κ)J(κ)K((de)) and V(κ)K((de)) rearrangements with DNA of single cells and a comparison with B lineage cell development in mouse bone marrow, allow to delineate the human B lymphocyte pathway of development as follows: CD34(+)V(preB) (+)RAG-1(+)TdT(+), D(H)J(H)-rearranged, κL germline cycling pre-B I cells → CD34(−)V(preB) (+)μH chain(+) (pre-B receptor(+)) RAG-1(−)TdT(−), V(H)D(H)J(H)-rearranged, κL germline, cycling pre-B II cells → CD34(−)V(preB) (−), intracytoplasmic μH chain(+) (pre-B receptor(−)) RAG-1(+/−) TdT(−), V(H)D(H)J(H)-rearranged, mainly κL germline cycling pre-B II cells → CD34(−)V(preB) (−) intracytoplasmic μH chain(+), RAG-1(+)TdT(−), V(H)D(H)J(H)-rearranged, V(κ)J(κ)-rearranged, IgM(−), resting pre-B II cells CD34(+)V(preB) (−), sIgM(+), RAG-1(+)TdT(−), V(H)D(H)J(H)- and V(κ)J(κ)-rearranged IgM(+) immature B cells → CD34(−), CD10(−), sIgM(+)/sIgD(+) mature B cells. …”
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“…We identified two subpopulations of GEC (dim(tdT) and bright(tdT)) based on the fluorescence intensity of the Tek(tdT) signal. …”
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“…Herein, we compare the effect of three kinds of TDT and analyze the use of TDT material and size to prevent AL, which may better prevent the occurrence of AL. …”
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“…The role of TDT in musician’s dystonia (MD) in contrast is less clear with preceding studies reporting inconclusive results. …”
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“…METHODOLOGY/PRINCIPAL FINDINGS: To further clarify whether visual perceptual training improves the measures of reading performance, eighteen children with dyslexia and eighteen typically developed readers that were age- and IQ-matched completed a series of reading measures before and after visual texture discrimination task (TDT) training. Prior to the TDT training, each group of children was split into two equivalent training and non-training groups in terms of all reading measures, IQ, and TDT. …”
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“…BACKGROUND AND AIM: Dysregulation of glucose metabolism is a common complication of transfusions in Transfusion Dependent Thalassemia (TDT) patients. For early diagnosis of glucose disturbances, screening is recommended. …”
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“…Standard treatment of the most severe forms, i.e., transfusion-dependent thalassemia (TDT) with long-term transfusion and iron chelation, represents a considerable medical, psychological, and economic burden. …”
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“…Beta-thalassemia and particularly its transfusion-dependent form (TDT) is a demanding clinical condition, requiring life-long care and follow-up, ideally in specialized centers and by multidisciplinary teams of experts. …”
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“…BACKGROUND: Effective strategies are needed to increase implementation and sustainability of evidence-based tobacco dependence treatment (TDT) in public health systems in low- and middle-income countries (LMICs). …”
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“…BACKGROUND: Transfusion-dependent thalassaemia (TDT) is a hereditary blood disorder in which blood transfusion is the mainstay treatment to prolong survival and improve quality of life. …”
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“…Interestingly, when loop1 from TdT was inserted in Polμ (substituting its cognate loop1), the resulting chimaera displayed TdT activity, preferentially inserting dGTP residues, but had a strongly reduced template-dependent polymerization activity. …”
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“…Optimized methods for extraction and enzyme assay in crude tissue preparations were used to determine the amounts of terminal deoxnucleotidyl transferase (TdT) in malignant lymphomas. The TdT concentration was increased only in lymphoblastic lymphomas (LL) and was as high in these tumours as in the white blood cells from untreated patients with acute lymphoblastic leukaemia (ALL). …”
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“…In conclusion, this study identifies new characteristics of TDT patients which may have relevance in developing biomarkers and therapeutics.…”
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“…Using a multi-stage sampling, patients diagnosed with TDT and receiving iron chelating therapy were sampled. …”
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“…In the presence of excess Mg(II) ions, TdT did not bind to the H-tailed strands; thus, further elongation was impeded. …”
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“…Severe iron overload started earlier in patients with TDT than NTDT and was associated with diabetes mellitus (adjusted odds ratio (AOR) = 6.2, p-value = 0.02). …”
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“…All animals showed complete depletion of medullary thymocytes (CD4+8- and CD4-8+, T cell receptor [TCR] alpha/beta hi, Thy-1med/low, terminal deoxynucleotidyl transferase negative [TdT-]) and a 50% reduction in the number of TdT- cortical thymocytes (CD4+8+, TCR alpha/beta low, Thy- 1med) within 1 wk of CSA treatment. …”
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“…Comparisons with single-locus and haplotype-based TDT methods demonstrate that our approach consistently outperforms the TDT-based approaches regardless of disease models, local LD structures or allele/haplotype frequencies. …”
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“…The family-based association was significant between Tourette syndrome and rs4979356 (TDT: χ2 = 4.804, P = 0.033; HRR = 1.75, P = 0.002; HHRR = 1.32, P = 0.027), and transmission disequilibrium was suspected for rs4979357 (TDT: χ2 = 3.969, P = 0.053; HRR = 1.84, P = 0.001; HHRR = 1.29, P = 0.044). …”
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