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2041por Downs, Johnny, Hotopf, Matthew, Ford, Tamsin, Simonoff, Emily, Jackson, Richard G., Shetty, Hitesh, Stewart, Robert, Hayes, Richard D.“…The fully adjusted model indicated that comorbid diagnoses including hyperkinetic (OR 1.44, 95 %CI 1.01–2.06), psychotic (5.71, 3.3–10.6), depressive (2.36, 1.37–4.09), obsessive–compulsive (2.31, 1.16–4.61) and tic disorders (2.76, 1.09–6.95) were associated with antipsychotic use. …”
Publicado 2015
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2042por Aida, Tomomi, Yoshida, Junichi, Nomura, Masatoshi, Tanimura, Asami, Iino, Yusuke, Soma, Miho, Bai, Ning, Ito, Yukiko, Cui, Wanpeng, Aizawa, Hidenori, Yanagisawa, Michiko, Nagai, Terumi, Takata, Norio, Tanaka, Kenji F, Takayanagi, Ryoichi, Kano, Masanobu, Götz, Magdalena, Hirase, Hajime, Tanaka, Kohichi“…Here, we show that astrocyte-specific GLT1 inducible knockout (GLAST(CreERT2/+)/GLT1(flox/flox), iKO) mice exhibit pathological repetitive behaviors including excessive and injurious levels of self-grooming and tic-like head shakes. Electrophysiological studies reveal that excitatory transmission at corticostriatal synapse is normal in a basal state but is increased after repetitive stimulation. …”
Publicado 2015
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2043“…The CEUS images were analyzed, and time–intensity curves (TICs) were obtained. Hematoxylin–eosin and immunohistochemistry staining was performed on tissue specimens, according to which the expressions of estrogen receptor (ER), c-erb-B2, p53, and Ki-67 were measured. …”
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2044por McGinn, Olivia, Gupta, Vineet K., Dauer, Patricia, Arora, Nivedita, Sharma, Nikita, Nomura, Alice, Dudeja, Vikas, Saluja, Ashok, Banerjee, Sulagna“…Further, treatment with triptolide resulted in a decreased activity of Sp1 and NF-kB the two major oncogenic signaling pathway in pancreatic cancer along with a decreased tumor initiating cell (TIC) population in pancreatic tumor.…”
Publicado 2017
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2045por Journigan, V. Blair, Polgar, Willma E., Tuan, Edward W., Lu, James, Daga, Pankaj R., Zaveri, Nurulain T.“…On the other hand, modifications of the 3-hydroxyphenyl pharmacophore, but not the 7-hydroxy Tic pharmacophore, are better tolerated at kappa and mu receptors and yield very high affinity multifunctional (e.g. 12) or highly selective (e.g. 16) kappa ligands. …”
Publicado 2017
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2046por Yamaji, Masayuki, Ota, Akinobu, Wahiduzzaman, Md, Karnan, Sivasundaram, Hyodo, Toshinori, Konishi, Hiroyuki, Tsuzuki, Shinobu, Hosokawa, Yoshitaka, Haniuda, Masayuki“…To investigate the effects of Akt inhibitors on MPM cell survival, we examined the effects of nine selective Akt inhibitors, namely, afuresertib, Akti‐1/2, AZD5363, GSK690693, ipatasertib, MK‐2206, perifosine, PHT‐427, and TIC10, on six MPM cell lines, namely, ACC‐MESO‐4, Y‐MESO‐8A, MSTO‐211H, NCI‐H28, NCI‐H290, and NCI‐H2052, and a normal mesothelial cell line MeT‐5A. …”
Publicado 2017
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2047por Liu, Fenxiang, Tong, Chunfa, Tao, Shentong, Wu, Jiyan, Chen, Yuhua, Yao, Dan, Li, Huogen, Shi, Jisen“…Our method not only incorporated the various segregations and linkage phases of molecular markers, but also applied Takeuchi’s information criterion (TIC) to discriminate the QTL segregation type among several possible alternatives. …”
Publicado 2017
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2048“…METHODS: 62 healthy participants, young (<30 yo) and old (>60 yo), played a 3D tic-tac-toe game against an embodied (a robotic arm) and a non-embodied (a computer-controlled lighting system) partner. …”
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2049por Huang, Rong, Li, Fangsen, Liu, Tong, Zhao, Yanfei, Zhu, Yafeng, Shen, Yang, Lu, Xiaoming, Huang, Zengli, Liu, Jianping, Zhang, Liqun, Zhang, Shuming, Li, Zhanping, Dingsun, An, Yang, Hui“…At the Ti/GaO(x) interface, TiC(x) components were also detected due to the reaction between metal Ti and surface-adsorbed C species. …”
Publicado 2018
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2050por van der Spek, Nadia, Vos, Joël, van Uden-Kraan, Cornelia F, Breitbart, William, Cuijpers, Pim, Knipscheer-Kuipers, Kitty, Willemsen, Vincent, Tollenaar, Rob AEM, van Asperen, Christi J, Leeuw, Irma M Verdonck-de“…Secondary outcome measures address quality of life (EORTC-30), anxiety and depression (HADS), hopelessness (BHS), optimism (LOT-R), adjustment to cancer (MAC), and costs (TIC-P, EQ-5D, PRODISQ). DISCUSSION: Meaning-focused coping is key to adjustment to life after cancer, however, there is a lack of evidence based psychological interventions in this area. …”
Publicado 2018
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2051por Raposo, Marcos Túlio, Reis, Martha Cerqueira, Caminha, Ana Virgínia de Queiroz, Heukelbach, Jörg, Parker, Lucy Anne, Pastor-Valero, Maria, Nemes, Maria Ines Battistella“…We identified factors associated with grade 2 disability (G2D) using logis tic regression. RESULTS: In total, 38 (17.1%) participants were diagnosed with G2D, and 106 (47.7%) with grade 1 disabilities (G1D). …”
Publicado 2018
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2052por Záhonová, Kristína, Füssy, Zoltán, Birčák, Erik, Novák Vanclová, Anna M. G., Klimeš, Vladimír, Vesteg, Matej, Krajčovič, Juraj, Oborník, Miroslav, Eliáš, Marek“…Strikingly, no homologs of any key component of the TOC/TIC system and the plastid division apparatus are discernible in euglenophytes, and the machinery for intraplastidial protein targeting has been simplified by the loss of the cpSRP/cpFtsY system and the SEC2 translocon. …”
Publicado 2018
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2053por Fernández Arias, M., Mazarico, E., Gonzalez, A., Muniesa, M., Molinet, C., Almeida, L., Gómez Roig, M. D.“…There were no statistically significant differences between cases and controls in the standard blood tests for thrombophilias in plasma or the TiC test for genetic variables. One clinical-genetic model was generated using variables with the lowest P values: ABO, body mass index, C_rs5985, C_rs6025, and protein S. …”
Publicado 2019
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2054por Zhao, Yue, Lu, Qijue, Li, Chunguang, Wang, Xinyu, Jiang, Long, Huang, Lei, Wang, Chao, Chen, Hezhong“…ESCC is believed to arise from tumour initiating cells (TICs), which contribute to metastasis and chemoresistance. …”
Publicado 2019
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2055por Mohammadi, Mohammad Reza, Mostafavi, Seyed-Ali, Hooshyari, Zahra, Khaleghi, Ali, Ahmadi, Nastaran“…In boys’ subgroup, depression and separation anxiety were mostly seen among the underweight category, while tic disorder was mostly seen in the obese category. …”
Publicado 2019
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2056por Kitajima-Koga, Aya, Baslam, Marouane, Hamada, Yuuki, Ito, Namiko, Taniuchi, Tomoko, Takamatsu, Takeshi, Oikawa, Kazusato, Kaneko, Kentaro, Mitsui, Toshiaki“…Furthermore, OsLACS9 is also one of the proteins transported to plastids without a transit peptide or involvement of the Toc/Tic complex system. To identify the plastid-targeting signal of OsLACS9, the transient expression and localization of a series of N-terminal truncated OsLACS9-green fluorescent protein (GFP) fusion proteins were examined. …”
Publicado 2020
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2057por Ling, Wenwu, Nie, Ji, Zhang, Dingyue, Yang, Qianru, Jin, Hongyu, Ou, Xuejin, Ma, Xuelei, Luo, Yan“…We analyzed parameters of the time–intensity curve (TIC), which includes time to peak (TP), area under the gamma curve (AUC), and peak intensity (PI). …”
Publicado 2020
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2058“…Multiple comorbidity, autism spectrum disorder, oppositional defiant or conduct disorders and tic disorders relate to ADHD symptom severity. CONCLUSIONS: Comorbidity subgroups with ADHD differ in functional impairment and ADHD symptoms severity. …”
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2059“…The average early enhancement rate was 116.96±45.26%. TICs of type III were observed in all cases. In conclusion, MRI of IMPC demonstrated typical features of malignant tumors and lymphatic vessel infiltration, suggesting that MRI may exhibit guiding significance for the diagnosis and treatment planning of IMPC.…”
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2060por Wang, Dan, Tian, Hui-ling, Cui, Xia, Wang, Qian, Guo, Fan, Zhang, Wen, Tang, Qi-sheng“…CONCLUSIONS: JPZDD alleviated both tic and anxiety symptoms and the mechanism may be via reducing the expression of 5-HT2C mRNA in the striatum, increasing the concentration of 5-HT, and enhancing the activity of the 5-HT system, which in turn exerts neuro-inhibition.…”
Publicado 2020
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