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2601por Yan, Bing, Stantic, Marina, Zobalova, Renata, Bezawork-Geleta, Ayenachew, Stapelberg, Michael, Stursa, Jan, Prokopova, Katerina, Dong, Lanfeng, Neuzil, Jiri“…Emerging drugs that target TICs are becoming a focus of contemporary research. …”
Publicado 2015
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2602por Chen, Yi, Yu, Dongke, Zhang, Hao, He, Hongwei, Zhang, Caixia, Zhao, Wuli, Shao, Rong-guang“…Background: EpCAM or CD133 has been used as the tumor initiating cells (TICs) marker in hepatocellular carcinoma (HCC). We investigated whether cells expressing with both EpCAM and CD133 surface marker were more representative for TICs in hepatocellular carcinoma Huh7 cells. …”
Publicado 2012
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2603“…Tourette's syndrome (TS) patients experiencing severe tics and behavioral disturbances can have a rare complication called rhabdomyolysis (RML), which is characterized by the breakdown of muscle tissue. …”
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2604por Li, Qiang, Lin, Haishuang, Rauch, Jack, Deleyrolle, Loic P., Reynolds, Brent A., Viljoen, Hendrik J., Zhang, Chi, Zhang, Chi, Gu, Linxia, Van Wyk, Erika, Lei, Yuguo“…There is growing interest to develop drugs that specifically target to glioblastoma tumor-initiating cells (TICs). However, the cost-effective production of large numbers of high quality glioblastoma TICs for drug discovery with current cell culturing technologies remains very challenging. …”
Publicado 2018
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2605por Luo, Qianqian, Tang, Yu, Jiang, Zhonglin, Bao, Hongchu, Fu, Qiang, Zhang, Hongqin“…BACKGROUND: Human umbilical cord mesenchymal stem cells (hUCMSCs, retrospectively registered) have a lot of promise for treating theca interstitial cells(TICs) dysfunction in premature ovarian insufficiency (POI). …”
Publicado 2022
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2606“…The children and their parents were interviewed about their perception of significant/bothersome symptoms of motor tics, vocal tics, learning difficulties, attention deficit disorder, hyperactivity, obsessions, compulsions, and rage attacks. …”
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2607por Lu, Xueyan, Bao, Hongchu, Cui, Linlu, Zhu, Wenqian, Zhang, Lianshuang, Xu, Zheng, Man, Xuejing, Chu, Yongli, Fu, Qiang, Zhang, Hongqin“…BACKGROUND: Previous studies of primary ovarian insufficiency (POI) have focused on granulosa cells (GCs) and ignored the role of theca-interstitial cells (TICs). This study aims to explore the mechanism of the protective effects of human umbilical cord-derived mesenchymal stem cells (hUMSCs) on ovarian function in POI rats by regulating autophagy of TICs. …”
Publicado 2020
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2608por Sun, Heng, Sui, Bowen, Li, Yu, Yan, Jun, Cao, Mingming, Zhang, Lijia, Liu, Songjiang“…Form the expression of non-small cell lung cancer (NSCLC). TICS values were calculated and grouped according to TICS values, and we used mRNA expression profile data to perform GSEA in non-small-cell lung cancer patients. …”
Publicado 2021
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2609“…Those patients who underwent chemotherapy were used to further analyze the value of TICS for predicting the chemotherapy response. Furthermore, the difference in the somatic mutations and immune-related molecules between the TICS subgroups was analyzed. …”
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2610“…Although it has been used to predict current and future cognitive function in older adults, no studies have examined if the mTICS can predict daily functioning. AIMS: The current study sought to examine the relationship between the mTICS and a performance-based measure of daily functioning. …”
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2611por Kendellen, Megan F., Bradford, Jennifer W., Lawrence, Cortney L., Clark, Kelly S., Baldwin, Albert S.“…Tumor-initiating cells (TICs) are a sub-population of cells that exhibit a robust ability to self-renew and contribute to the formation of primary tumors, the relapse of previously treated tumors, and the development of metastases. …”
Publicado 2013
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2612“…We have previously identified that miR-31 may play suppressive roles in α2δ1(+) hepatocellular carcinoma (HCC) TICs. Here, we confirm that the expression of miR-31 is significantly downregulated in α2δ1(+) HCC TICs. …”
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2613“…Increasing evidence suggests that tumor-initiating cells (TICs), also called cancer stem cells, are partly responsible for resistance to DNA-damaging treatment. …”
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2614“…We compared participants’ change in CogState to change in the Telephone Interview for Cognitive Status (TICS). Participants (N = 41, age M = 75.5, 66% female) completed monthly CogState and two TICS assessments over two years. …”
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2615“…The expression and prognostic role of programmed death ligand-1 (PD-L1) on tumor-infiltrating immune cells (TICs) has not been determined in urothelial carcinoma (UC) with variant histology. …”
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2616Scalable Production of Glioblastoma Tumor-initiating Cells in 3 Dimension Thermoreversible Hydrogelspor Li, Qiang, Lin, Haishuang, Wang, Ou, Qiu, Xuefeng, Kidambi, Srivatsan, Deleyrolle, Loic P., Reynolds, Brent A., Lei, Yuguo“…There is growing interest in developing drugs that specifically target glioblastoma tumor-initiating cells (TICs). Current cell culture methods, however, cannot cost-effectively produce the large numbers of glioblastoma TICs required for drug discovery and development. …”
Publicado 2016
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2617por Caminear, Michael W., Harrington, Brittney S., Kamdar, Rahul D., Kruhlak, Michael J., Annunziata, Christina M.“…EOC recurrence is considered to be driven by the survival of chemoresistant, stem-like tumor-initiating cells (TICs). We previously showed that disulfiram, an ALDH inhibitor, effectively targeted TICs compared to adherent EOC cells in terms of viability, spheroid formation, oxidative stress and also prevented relapse in an in vivo model of EOC. …”
Publicado 2022
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2618“…Nevertheless, its effects on the elimination of tumor-initiating cells of head and neck cancer (HNC-TICs) remain unclear. Here, we investigated the inhibitory effect of genistein on HNC-TICs and potential mechanisms. …”
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2619“…Tourette syndrome (TS) is a neurologic and behavioral disorder consisting of motor and phonic tics with onset in childhood or adolescence. The severity of tics can range from barely perceptible to severely impairing due to social embarrassment, discomfort, self-injury, and interference with daily functioning and school or work performance. …”
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2620“…Survival analysis showed that TICs play a crucial role in the survival of OC patients. …”
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