“…Ctbp2 is a uniquely targetable oncogenic transcriptional coregulator, exhibiting overexpression in most common solid tumors, and critical to the tumor-initiating cell (TIC) transcriptional program. In the “CKP” mouse pancreatic ductal adenocarcinoma (PDAC) model driven by mutant K-Ras, Ctbp2 haploinsufficiency prolonged survival, abrogated peritoneal metastasis, and caused dramatic downregulation of c-Myc, a known critical dependency for TIC activity and tumor progression in PDAC. …”
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“…According to the qualitative analysis, none of the lesions with Type I time intensity curves (TIC) were malignant and none of the masses with Type III TICs were benign. …”
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“…We hypothesized that: CRP could be associated with tumor immune contexture (TIC) in never-smokers and both these two parameters may improve their prognosis. …”
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“…The in vitro erdafitinib response was accurately reflected on mouse xenografts of TIC spheroid lines. However, we found little correlation between their genetic/genomic alterations of TIC spheroids and the sensitivity to the FGFR inhibitor. …”
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“…Trauma-induced coagulopathy (TIC) is caused by post-traumatic tissue injury and manifests as hypercoagulability that leads to thromboembolism or hypocoagulability that leads to uncontrollable massive hemorrhage. …”
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“…With respect to co-morbid disease, there was a significant improvement in a patient with tic disorder's Total Tic Severity Score (TTSS) (p = 0.005). …”
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“…Despite these clinical benefits, TIC is not routinely taught in undergraduate medical education. …”
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“…The calculated mean critical stress intensity factor K(Ic) of the steel samples with deposited layers of cobalt alloy reinforced with TiC and PD-W particles was 4.3 MPa⋅ [Formula: see text] higher than that of the nickel alloy reinforced with TiC and WC-W(2)C particles.…”
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“…CONCLUSION: We successfully evaluated the blood supply pattern by the TIC analysis and identified flow voids using 3.0 T MRI. …”
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“…Increasing evidence suggests that the presence of tumor initiating cells (TICs) is the principal cause of tumor recurrence and chemoresistance. …”
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“…TS was largely thought of as a rare and bizarre condition until the 1960s, when the beneficial effects of neuroleptics on tic symptoms led to an exponential increase in neuroscientific research. …”
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“…Uncontrolled hemorrhage and subsequent trauma-induced coagulopathy (TIC) are still the principle causes for preventable death after trauma and early detection and aggressive management have been associated with reduced mortality. …”
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“…The specific novelty of this work lies in the processing of fine-sized titanium and chromium carbides (TiC and Cr(3)C(2)) in the form of aqueous suspensions to fabricate wear-resistant coatings by SPS. …”
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“….% Al(2)O(3), Al(2)O(3)–TiC, Al(2)O(3)–TiC–ZrO(2), and Al(2)O(3)–TiN. In almost all tests, the composite with silicon carbide demonstrated better wear resistance, longer tool lifetime, and the ability to cut at higher speeds. …”
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“…TiC particles were formed under the high temperature caused by the cavitation effect, and they detached from the interface due to the sound pressure, which resulted in consistently sufficient contact on the wetting interface. …”
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“…Tourette Syndrome (TS) is a neurodevelopmental condition characterized by the presence of tics and associated behavioral problems. Yale Global Tic Severity Scale (YGTSS), The PedsQL Pediatric Pain Questionnaire, and Pediatric Pain Coping Inventory were used to assess the severity of tics, the severity of the pain, the location of the pain and pain coping strategies both from children’s and parents’ perspectives. …”
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