“…The present study supports the use of low-frequency rTMS to improve tics and OCD symptoms in patients with severe, medication-refractory TS-OCD. …”
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“…The strategy was confirmed in the following primary processes: firstly, different concentration of paeoniflorin, rat liver microsomes, coenzymes and different incubated conditions were optimized to build a biotransformation model of rat liver microsomes in vitro by high performance liquid chromatography with diode array detection (HPLC-DAD); secondly, the metabolites of paeoniflorin in rat liver microsomes were detected and screened using UPLC-Q-TOF-MS/MS by comparing the total ion chromatogram (TIC) of the experimental group with those of control groups; finally, the molecular formulae and corresponding chemical structures of paeoniflorin metabolites were identified by comparing the MS and MS/MS spectra with the self-constructed database and simulation software. …”
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“…Furthermore, we demonstrate the generality of tile displacement for occurring at any location in an array in any order, illustrated as a tic-tac-toe game. Our results suggest that tile displacement is a simple-yet-powerful mechanism that opens up the possibility for complex structural components in artificial molecular machines to undergo information-based reconfiguration in response to their environments.…”
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“…It was demonstrated that GnRH-III-[(2)ΔHis,(3)d-Tic,(4)Lys(Bu),(8)Lys(Dau=Aoa)] is a highly potent and promising anticancer drug delivery system for targeted tumor therapy.…”
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“…Joints welded with an AA7075 filler rod containing TiC nanoparticles not only exhibit fine globular grains and a modified secondary phase, both which intrinsically eliminate the materials hot crack susceptibility, but moreover show exceptional tensile strength in both as-welded and post-weld heat-treated conditions. …”
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“…The mean enhancement rate (ER) was calculated as enhancement intensity (EI)/rise time (RT) results from time-intensity curve (TIC) during CEUS. After a mean follow-up of 33.5±9.9 months, the correlation of ER and postoperative overall survival (OS) and disease-free survival (DFS) was analyzed using univariate and multivariate analysis. …”
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“…The DEK5 protein is homologous to rice SSG4, Arabidopsis thaliana EMB2410/TIC236, and Escherichia coli tamB. TamB functions in bacterial outer membrane biogenesis. …”
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“…Tourette syndrome is a common neurodevelopmental disorder defined by the presence of tics, stereotyped involuntary movements and phonations. …”
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“…The anti-tumor activity of the previously developed GnRH-III-[(4)Lys(Bu),(8)Lys(Dau=Aoa)] conjugate and the novel synthesized GnRH-III-[(2)ΔHis,(3)d-Tic,(4)Lys(Bu),(8)Lys(Dau=Aoa)] conjugate, containing the anti-cancer drug daunorubicin, were evaluated. …”
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“…Herein, a new bergamottin containing a nitroxide moiety (SL-bergamottin, SL-BM, 10) was synthesized; chemically characterized, evaluated as a potential inhibitor of the CYP2C19, CYP3A4, and CYP2C9 enzymes; and compared to BM and known inhibitors such as ketoconazole (KET) (3A4), warfarin (WAR) (2C9), and ticlopidine (TIC) (2C19). The antitumor activity of the new SL-bergamottin was also investigated. …”
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“…The microstructural evidence showed that the impact of TiC and Ti(2)NiO(x) was very different in the pitting process. …”
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“…The MDs associated with MTZ were 69 restless legs syndrome (RLS), 35 tremors, 10 akathisia (AKT), 9 periodic limb MD, 6 dystonia, 4 rapid eye movement sleep behavior disorders, 3 dyskinesia, 2 parkinsonism, and 1 tic, and in the group not clearly identified, 18 restlessness, 15 hyperkinesis, and 1 extrapyramidal symptom. …”
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“…Combination of β(3)hArg and Dmt led to peptide 7, a MOR agonist, showing the highest NTS2 affinity described to date (K(i) = 3 pM) and good NTS1 affinity (K(i) = 4 nM), providing a >1300-fold NTS2 selectivity. The (6-OH)Tic-containing analogue 9 also exhibited high NTS2 affinity (K(i) = 1.7 nM), with low NTS1 affinity (K(i) = 4.7 μM), resulting in an excellent NTS2 selectivity (>2700). …”
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“…Samples are composed of an amorphous Si-based ceramic matrix in which TiN(x)C(y) nanocrystals (x + y = 1) are homogeneously formed “in situ” in the matrix during the process and evolve toward fully crystallized compounds as TiN/Si(3)N(4), TiN(x)C(y) (x + y = 1)/SiC and TiC/SiC nanocomposites after annealing to 1800 °C as a function of the atmosphere.…”
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“…These processes are reflected in significantly different time intensity curve (TIC) and several kinetic parameters for targeted versus non-targeted NBs or LUMASON MBs. …”
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“…During brazing, Ti, Cr, and other carbide forming elements diffused to C/C composite side, forming Cr(3)C(2), Cr(7)C(3), TiC, and other carbides, and realizing metallurgical joining between the brazing filler metal and C/C composite. …”
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“…Entire chairside time ranged from 43 min 35 s (CER_C) to 58 min 43 s (TI_C). Pure chairside working time ranged from 15 min 21 s (CER_CW) to 23 min 17 s (TI_CW). …”
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“…Sensitive real-time detection of vapors produced by toxic industrial chemicals (TICs) always represents a stringent priority. Hydrogen cyanide (HCN) is definitely a TIC, being widely used in various industries and as an insecticide; it is a reactive, very flammable, and highly toxic compound that affects the central nervous system, cardiovascular system, eyes, nose, throat, and also has systemic effects. …”
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“…CIBERSORT analysis identified nine TIC subsets that correlated with ITK expression. …”
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“…We present the use of the different input parameters of a laboratory- and a field long-term monitoring dataset including dissociation constants of carbonic acid measured as total inorganic carbon (TIC) and total CO(2) concentration (TCO(2)) or total alkalinity (TA), together with hydrogeochemical and -physical parameters. …”
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