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  1. 1981
    “…Therefore, in order to fill this gap, aim of the present work was to evaluate their mutagenicity on TK6 cells. On the basis of cytotoxicity and cytostasis results, we selected the concentrations (35–100 µM) to be used in the further analysis. …”
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    Evaluation of Cytotoxic and Mutagenic Effects of the Synthetic Cathinones Mexedrone, α-PVP and α-PHP
  2. 1982
    “…Selinexor, recombinant nonpathogenic polio-rhinovirus, and GBM-vaccine of autologous fibroblasts retrovirally transfected with TFG-IL4-Neo-TK vector have all also shown initial clinical benefit in terms of prolonging survival. …”
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    Neurocytological Advances in the Treatment of Glioblastoma Multiforme
  3. 1983
    “…It was found that X-rays and Fe ion beams caused clustered DNA damage in human TK6 cells, whereas Fenton's reagents did it less efficiently, highlighting clustered DNA damage as a signature of ionizing radiation. …”
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    Formation of clustered DNA damage in vivo upon irradiation with ionizing radiation: Visualization and analysis with atomic force microscopy
  4. 1984
    “…Therefore, the inhibition of TK was comparable to or higher than NIL and IM for many novel compounds, while most of the new analogs showed only moderate potency against HO-1. …”
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    Novel Tyrosine Kinase Inhibitors to Target Chronic Myeloid Leukemia
  5. 1985
    “…Recently, we proved its ability to induce cytotoxic, cytostatic, and cell differentiation effects on leukemic cell lines and its antimutagenic activity on TK6 cells. In the current study, to further define its chemopreventive profile, Jurkat and HL-60 cells were treated with 6-MITC for 24 h. …”
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    6-(Methylsulfonyl) Hexyl Isothiocyanate: A Chemopreventive Agent Inducing Autophagy in Leukemia Cell Lines
  6. 1986
    “…Many small-molecule inhibitors of EGFR tyrosine kinase (EGFR-TK), from medicinally privileged molecules to commercial drugs, have been overviewed. …”
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    Small Molecule EGFR Inhibitors as Anti-Cancer Agents: Discovery, Mechanisms of Action, and Opportunities
  7. 1987
    por Burrows, P.N., Catalan Lasheras, N., Linssen, L., Petrič, M., Robson, A., Schulte, D., Sicking, E., Stapnes, S., Charles, T.K., Giansiracusa, P.J., Lucas, T.G., Rassool, R.P., Volpi, M., Balazs, C., Afanaciev, K., Makarenko, V., Patapenka, A., Zhuk, I., Collette, C., Boland, M.J., Abusleme Hoffman, A.C., Diaz, M.A., Garay, F., Chi, Y., He, X., Pei, G., Pei, S., Shu, G., Wang, X., Zhang, J., Zhao, F., Zhou, Z., Chen, H., Gao, Y., Huang, W., Kuang, Y.P., Li, B., Li, Y., Meng, X., Shao, J., Shi, J., Tang, C., Wang, P., Wu, X., Zha, H., Ma, L., Han, Y., Fang, W., Gu, Q., Huang, D., Huang, X., Tan, J., Wang, Z., Zhao, Z., Uggerhøj, U.I., Wistisen, T.N., Aabloo, A., Aare, R., Kuppart, K., Vigonski, S., Zadin, V., Aicheler, M., Baibuz, E., Brücken, E., Djurabekova, F., Eerola, P., Garcia, F., Haeggström, E., Huitu, K., Jansson, V., Kassamakov, I., Kimari, J., Kyritsakis, A., Lehti, S., Meriläinen, A., Montonen, R., Nordlund, K., Österberg, K., Saressalo, A., Väinölä, J., Veske, M., Farabolini, W., Mollard, A., Peauger, F., Plouin, J., Bambade, P., Chaikovska, I., Chehab, R., Delerue, N., Davier, M., Faus-Golfe, A., Irles, A., Kaabi, W., LeDiberder, F., Pöschl, R., Zerwas, D., Aimard, B., Balik, G., Blaising, J.-J., Brunetti, L., Chefdeville, M., Dominjon, A., Drancourt, C., Geoffroy, N., Jacquemier, J., Jeremie, A., Karyotakis, Y., Nappa, J.M., Serluca, M., Vilalte, S., Vouters, G., Bernhard, A., Bründermann, E., Casalbuoni, S., Hillenbrand, S., Gethmann, J., Grau, A., Huttel, E., Müller, A.-S., Peiffer, P., Perić, I., Saez de Jauregui, D., Emberger, L., Graf, C., Simon, F., Szalay, M., van der Kolk, N., Brass, S., Kilian, W., Alexopoulos, T., Apostolopoulos, T., Gazis, E.N., Gazis, N., Kostopoulos, V., Kourkoulis, S., Heilig, B., Lichtenberger, J., Shrivastava, P., Dayyani, M.K., Ghasem, H., Hajari, S.S., Shaker, H., Ashkenazy, Y., Popov, I., Engelberg, E., Yashar, A., Abramowicz, H., Benhammou, Y., Borysov, O., Borysova, M., Levy, A., Levy, I., Alesini, D., Bellaveglia, M., Buonomo, B., Cardelli, A., Diomede, M., Ferrario, M., Gallo, A., Ghigo, A., Giribono, A., Piersanti, L., Stella, A., Vaccarezza, C., de Blas, J., Franceschini, R., D'Auria, G., Di Mitri, S., Abe, T., Aryshev, A., Fukuda, M., Furukawa, K., Hayano, H., Higashi, Y., Higo, T., Kubo, K., Kuroda, S., Matsumoto, S., Michizono, S., Naito, T., Okugi, T., Shidara, T., Tauchi, T., Terunuma, N., Urakawa, J., Yamamoto, A., Raboanary, R., Luiten, O.J., Stragier, X.F.D., Hart, R., van der Graaf, H., Eigen, G., Adli, E., Lindstrøm, C.A., Lillestøl, R., Malina, L., Pfingstner, J., Sjobak, K.N., Ahmad, A., Hoorani, H., Khan, W.A., Bugiel, S., Bugiel, R., Firlej, M., Fiutowski, T.A., Idzik, M., Moroń, J., Świentek, K.P., Brückman de Renstrom, P., Krupa, B., Kucharczyk, M., Lesiak, T., Pawlik, B., Sopicki, P., Turbiarz, B., Wojtoń, T., Zawiejski, L.K., Kalinowski, J., Nowak, K., Żarnecki, A.F., Firu, E., Ghenescu, V., Neagu, A.T., Preda, T., Zgura, I.S., Aloev, A., Azaryan, N., Boyko, I., Budagov, J., Chizhov, M., Filippova, M., Glagolev, V., Gongadze, A., Grigoryan, S., Gudkov, D., Karjavine, V., Lyablin, M., Nefedov, Yu., Olyunina, A., Rymbekova, A., Samochkine, A., Sapronov, A., Shelkov, G., Shirkov, G., Soldatov, V., Solodko, E., Trubnikov, G., Tyapkin, I., Uzhinsky, V., Vorozhtov, A., Zhemchugov, A., Levichev, E., Mezentsev, N., Piminov, P., Shatilov, D., Vobly, P., Zolotarev, K., BožovićJelisavčić, I., Kačarević, G., MilutinovićDumbelović, G., Pandurović, M., Radulović, M., Stevanović, J., Vukasinović, N., Lee, D.-H., Ayala, N., Benedetti, G., Guenzel, T., Iriso, U., Marti, Z., Perez, F., Pont, M., Trenado, J., Ruiz-Jimeno, A., Vila, I., Calero, J., Dominguez, M., Garcia-Tabares, L., Gavela, D., Lopez, D., Toral, F., Blanch Gutierrez, C., Boronat, M., Esperante, D., Fullana, E., Fuster, J., García, I., Gimeno, B., Gomis Lopez, P., González, D., Perelló, M., Ros, E., Villarejo, M.A., Vnuchenko, A., Vos, M., Borgmann, Ch., Brenner, R., Ekelöf, T., Jacewicz, M., Olvegård, M., Ruber, R., Ziemann, V., Aguglia, D., Alabau Gonzalvo, J., Alcaide Leon, M., Alipour Tehrani, N., Anastasopoulos, M., Andersson, A., Andrianala, F., Antoniou, F., Apyan, A., Arominski, D., Artoos, K., Assly, S., Atieh, S., Baccigalupi, C., Ballabriga Sune, R., Banon Caballero, D., Barnes, M.J., Barranco Garcia, J., Bartalesi, A., Bauche, J., Bayar, C., Belver-Aguilar, C., Benot Morell, A., Bernardini, M., Bett, D.R., Bettoni, S., Bettencourt, M., Bielawski, B., Blanco Garcia, O., Blaskovic Kraljevic, N., Bolzon, B., Bonnin, X.A., Bozzini, D., Branger, E., Brondolin, E., Brunner, O., Buckland, M., Bursali, H., Burkhardt, H., Caiazza, D., Calatroni, S., Campbell, M., Cassany, B., Castro, E., Cavaleiro Soares, R.H., Cerqueira Bastos, M., Cherif, A., Chevallay, E., Cilento, V., Corsini, R., Costa, R., Cure, B., Curt, S., Dal Gobbo, A., Dannheim, D., Daskalaki, E., Deacon, L., Degiovanni, A., De Michele, G., De Oliveira, L., Del Pozo Romano, V., Delahaye, J.P., Delikaris, D., Dias de Almeida, P.G., Dobers, T., Doebert, S., Doytchinov, I., Draper, M., Duarte Ramos, F., Duquenne, M., Egidos Plaja, N., Elsener, K., Esberg, J., Esposito, M., Evans, L., Fedosseev, V., Ferracin, P., Fiergolski, A., Foraz, K., Fowler, A., Friebel, F., Fuchs, J-F., Gaddi, A., Gamba, D., Garcia Fajardo, L., Garcia Morales, H., Garion, C., Gasior, M., Gatignon, L., Gayde, J-C., Gerbershagen, A., Gerwig, H., Giambelli, G., Gilardi, A., Goldblatt, A.N., Gonzalez Anton, S., Grefe, C., Grudiev, A., Guerin, H., Guillot-Vignot, F.G., Gutt-Mostowy, M.L., Hein Lutz, M., Hessler, C., Holma, J.K., Holzer, E.B., Hourican, M., Hynds, D., Ikarios, E., Inntjore Levinsen, Y., Janssens, S., Jeff, A., Jensen, E., Jonker, M., Kamugasa, S.W., Kastriotou, M., Kemppinen, J.M.K., Khan, V., Kieffer, R.B., Klempt, W., Kokkinis, N., Kossyvakis, I., Kostka, Z., Korsback, A., Koukovini Platia, E., Kovermann, J.W., Kozsar, C-I., Kremastiotis, I., Kröger, J., Kulis, S., Latina, A., Leaux, F., Lebrun, P., Lefevre, T., Leogrande, E., Liu, X., Llopart Cudie, X., Magnoni, S., Maidana, C., Maier, A.A., Mainaud Durand, H., Mallows, S., Manosperti, E., Marelli, C., Marin Lacoma, E., Marsh, S., Martin, R., Martini, I., Martyanov, M., Mazzoni, S., Mcmonagle, G., Mether, L.M., Meynier, C., Modena, M., Moilanen, A., Mondello, R., Moniz Cabral, P.B., Mouriz Irazabal, N., Munker, M., Muranaka, T., Nadenau, J., Navarro, J.G., Navarro Quirante, J.L., Nebo Del Busto, E., Nikiforou, N., Ninin, P., Nonis, M., Nisbet, D., Nuiry, F.X., Nürnberg, A., Ögren, J., Osborne, J., Ouniche, A.C., Pan, R., Papadopoulou, S., Papaphilippou, Y., Paraskaki, G., Pastushenko, A., Passarelli, A., Patecki, M., Pazdera, L., Pellegrini, D., Pepitone, K., Perez Codina, E., Perez Fontenla, A., Persson, T.H.B., Pitman, S., Pitters, F., Pittet, S., Plassard, F., Popescu, D., Quast, T., Rajamak, R., Redford, S., Remandet, L., Renier, Y., Rey, S.F., Rey Orozco, O., Riddone, G., Rodriguez Castro, E., Roloff, P., Rossi, C., Rossi, F., Rude, V., Ruehl, I., Rumolo, G., Sailer, A., Sandomierski, J., Santin, E., Sanz, C., Sauza Bedolla, J., Schnoor, U., Schmickler, H., Senes, E., Serpico, C., Severino, G., Shipman, N., Simoniello, R., Skowronski, P.K., Sobrino Mompean, P., Soby, L., Sollander, P., Solodko, A., Sosin, M.P., Spannagel, S., Sroka, S., Sterbini, G., Stern, G., Ström, R., Stuart, M.J., Syratchev, I., Szypula, K., Tecker, F., Thonet, P.A., Thrane, P., Timeo, L., Tiirakari, M., Tomas Garcia, R., Tomoiaga, C.I., Valerio, P., Vaňát, T., Vamvakas, A.L., Van Hoorne, J., Viazlo, O., Vicente Barreto Pinto, M., Vitoratou, N., Vlachakis, V., Weber, M.A., Wegner, R., Wendt, M., Widorski, M., Williams, O.E., Williams, M., Woolley, B., Wuensch, W., Wulzer, A., Uythoven, J., Xydou, A., Yang, R., Zelios, A., Zhao, Y., Zisopoulos, P., Benoit, M., Sultan, D M S, Riva, F., Bopp, M., Braun, H.H., Craievich, P., Dehler, M., Garvey, T., Pedrozzi, M., Raguin, J.Y., Rivkin, L., Zennaro, R., Guillaume, S., Rothacher, M., Aksoy, A., Nergiz, Z., Denizli, H., Keskin, U., Oyulmaz, K.Y., Senol, A., Ciftci, A.K., Baturin, V., Karpenko, O., Kholodov, R., Lebed, O., Lebedynskyi, S., Mordyk, S., Musienko, I., Profatilova, Ia., Storizhko, V., Bosley, R.R., Price, T., Watson, M.F., Watson, N.K., Winter, A.G., Goldstein, J., Green, S., Marshall, J.S., Thomson, M.A., Xu, B., You, T., Gillespie, W.A., Spannowsky, M., Beggan, C., Martin, V., Zhang, Y., Protopopescu, D., Apsimon, R.J., Bailey, I., Burt, G.C., Dexter, A.C., Edwards, A.V., Hill, V., Jamison, S., Millar, W.L., Papke, K., Casse, G., Vossebeld, J., Aumeyr, T., Bergamaschi, M., Bobb, L., Bosco, A., Boogert, S., Boorman, G., Cullinan, F., Gibson, S., Karataev, P., Kruchinin, K., Lekomtsev, K., Lyapin, A., Nevay, L., Shields, W., Snuverink, J., Towler, J., Yamakawa, E., Boisvert, V., West, S., Jones, R., Joshi, N., Bett, D., Bodenstein, R.M., Bromwich, T., Christian, G.B., Gohil, C., Korysko, P., Paszkiewicz, J., Perry, C., Ramjiawan, R., Roberts, J., Coates, T., Salvatore, F., Bainbridge, A., Clarke, J.A., Krumpa, N., Shepherd, B.J.A., Walsh, D., Chekanov, S., Demarteau, M., Gai, W., Liu, W., Metcalfe, J., Power, J., Repond, J., Weerts, H., Xia, L., Zhang, J., Zupan, J., Wells, J.D., Zhang, Z., Adolphsen, C., Barklow, T., Dolgashev, V., Franzi, M., Graf, N., Hewett, J., Kemp, M., Kononenko, O., Markiewicz, T., Moffeit, K., Neilson, J., Nosochkov, Y., Oriunno, M., Phinney, N., Rizzo, T., Tantawi, S., Wang, J., Weatherford, B., White, G., Woodley, M.
    Publicado 2018
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    The Compact Linear Collider (CLIC) - 2018 Summary Report
  8. 1988
    “…The preoperative mean kyphosis of deformed complex vertebrae was 83.39° ± 9.04°; the mean thoracic kyphosis (TK) and lumbar lordosis (LL) were 81.09° ± 8.51° and 80.51° ± 7.64°, respectively; the mean sagittal vertical axis (SVA) was 3.83 cm ± 1.43 cm. …”
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    Retrospective analysis of deformed complex vertebral osteotomy in children with severe thoracic post-tubercular angular kyphosis
  9. 1989
    “…The glycoplexes generated had suitable physicochemical properties and showed high ASGPR specificity and high transfection efficiency. Moreover, the HSV-TK/GCV suicide gene therapy strategy, mediated by PAMA(144)-co-PLAMA(19)-based nanocarriers, resulted in high antitumor activity in 2D and 3D culture models of HCC, which was significantly enhanced by the combination with small amounts of docetaxel. …”
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    Glycopolymers Mediate Suicide Gene Therapy in ASGPR-Expressing Hepatocellular Carcinoma Cells in Tandem with Docetaxel
  10. 1990
    “…RESULTS AND DISCUSSION: Species replacement, induced by climate related environmental change, significantly increased the above-ground biomass of shrublands, and TP and TK contents in topsoil. The succession from L. oblonga to V. negundo var. heterophylla communities resulted in the gradually replacement of cold-tolerant microbes with warm-affinity ones, and alterations of microbial communities involved in soil biogeochemical processes. …”
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    Microbial gradual shifts during the process of species replacement in Taihang Mountain
  11. 1991
    “…For this reason, the aim of this work was to explore the potential mutagenicity and genotoxicity of pure ATX-a and an ATX-a/CYN mixture using a battery of in vitro assays, including the bacterial reverse-mutation assay in Salmonella typhimurium (OECD 471) and the micronucleus test (MN) (OECD 487) on L5178Y Tk(+/−) cells. The results showed that ATX-a was not mutagenic either alone or in combination with CYN under the conditions tested. …”
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    In Vitro Mutagenic and Genotoxic Assessment of Anatoxin-a Alone and in Combination with Cylindrospermopsin
  12. 1992
    “…Starting from this evidence, the aim of this paper was to investigate the possibility to affect also the earlier phases of the carcinogenic process by evaluating Cs bark extract’s antimutagenic properties, in particular using the “In Vitro Mammalian Cell Micronucleus Test” on TK6 cells performed by flow cytometry. For this purpose, since an ideal chemopreventive agent should be virtually nontoxic, the first step was to exclude the extract’s genotoxicity. …”
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    Antimutagenicity and Antioxidant Activity of Castanea sativa Mill. Bark Extract
  13. 1993
    por Guang, Shouhong, Mertz, Janet E.
    Publicado 2005
    “…However, mRNAs can efficiently accumulate in the cytoplasm without intron excision if they contain cis-acting elements such as the post-transcriptional regulatory element (PRE) of hepatitis B virus (HBV), the constitutive transport element (CTE) of Mason–Pfizer monkey virus (MPMV), or the pre-mRNA processing enhancer (PPE) of herpes simplex virus' thymidine kinase (HSV-TK) gene. We compared the activities of these viral elements, the Rev-responsive element (RRE) of the human immunodeficiency virus (HIV), and the human c-Jun gene's enhancer (CJE), an element newly identified here, to enable expression of an intronless variant of the human β-globin gene. …”
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    Pre-mRNA processing enhancer (PPE) elements from intronless genes play additional roles in mRNA biogenesis than do ones from intron-containing genes
  14. 1994
    Publicado 1987
    “…The apparent transference numbers (Ti) of the basolateral membrane for K+ and Cl- were determined from the effect on the basolateral membrane equivalent electromotive force of a sudden increase in the serosal K+ concentration from 2.5 to 50 mM/liter or a decrease in the Cl- concentration from 101 to 10 mM/liter. TK and TCl were 0.71 +/- 0.05 and 0.04 +/- 0.01, respectively. …”
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    Characterization of the basolateral membrane conductance of Necturus urinary bladder
  15. 1995
    “…RESULTS: Ten CTCF-binding DNA fragments were inserted between the CMV enhancer and CMV minimal promoter driving the herpes simplex virus thymidine kinase (HSV-tk) gene in a vector expressing also the neo(R )gene under a separate promoter. …”
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    DNA fragments binding CTCF in vitro and in vivo are capable of blocking enhancer activity
  16. 1996
    “…To understand the role of microRNAs in TKI-resistant NSCLC, we examined TK receptor-mediated microRNA changes. Here we report that miR-30b/c and miR-221/222, modulated by both EGF and MET receptors, and miR-103, -203, controlled only by MET, play important roles in gefitinib-induced apoptosis and epithelial-mesenchymal transition (EMT) of NSCLC cells, in vitro and in vivo, by inhibiting the expression of Bim, APAF-1, PKC-ε and SRC genes. …”
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    EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers
  17. 1997
    “…To improve this system, we used an attB-TK fusion gene as a negative selection marker, thereby eliminating random integration during phiC31-mediated transfection. …”
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    Improved site-specific recombinase-based method to produce selectable marker- and vector-backbone-free transgenic cells
  18. 1998
    “…Blocking Beclin-1 expression with shRNA or parkin deletion prevents tyrosine kinase (TK) inhibition-induced amyloid clearance, suggesting that functional parkin-Beclin-1 interaction mediates amyloid degradation. …”
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    Tyrosine kinase inhibition increases functional parkin-Beclin-1 interaction and enhances amyloid clearance and cognitive performance
  19. 1999
    “…A new dominant allele, leo(tK3), leads to a complete loss of the pattern, suggesting a dominant negative impact on another component of gap junctions. …”
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    Gap junctions composed of connexins 41.8 and 39.4 are essential for colour pattern formation in zebrafish
  20. 2000
    “…Using the nucleoside kinase activity of herpes simplex virus thymidine kinase (hsvTK) on the non-natural nucleoside dP, a highly efficient, rapid, and liquid-based counter-selection system was established. …”
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    Liquid-Based Iterative Recombineering Method Tolerant to Counter-Selection Escapes
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