“…This study aimed to identify a supportive genomic biomarker could minimize the risk of misjudgments and aid appropriate decision making in genotoxicity testing. Human lymphoblastoid TK6 cells were treated with each of six DNA damage-inducing genotoxins (clastogens) or two genotoxins that do not cause DNA damage. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We also co-express Herpes Simplex Virus thymidine kinase (HSV-tk) with the transposase. Therefore, cells having residual transposase expression can be eliminated by the administration of ganciclovir. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…VaRank is implemented in Tcl/Tk, a scripting language which is platform-independent but has been tested only on Unix environment. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Some sequences of Blastocystis positive samples (TK18, 39, 46, 71, and 90) were closely related to animals (pig and cattle) indicating zoonotic risks. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We show that the p38 MAP kinase-dependent, EGFR tyrosine kinase (TK)-independent EGFR internalization induced by ultraviolet light C (UVC) or the cancer therapeutic cisplatin, is followed by diversion from the canonical endocytic pathway. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The positive modulation of one of the aptamers was confirmed by patch-clamp electrophysiology on L(tk) cells expressing GlyRα1 and/or GlyRα1β. This aptamer potentiated whole-cell Cl(−) currents in the presence of low concentrations of glycine. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Traditional knowledge (TK) based medicines have gained worldwide attention and presently the scientific community is focussing on proper pharmacological validation and identification of lead compounds for the treatment of various diseases. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We have constructed a vaccinia virus (WR strain) deleted for thymidine kinase (TK) and ribonucleotide reductase (RR) genes that expressed the fusion suicide gene FCU1 derived from the yeast cytosine deaminase and uracil phosphoribosyltransferase genes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, prolonged activation of apoptotic cell recognition receptors, such as the family of receptor tyrosine kinases Tyro3, Axl and MerTK (TAM), may delay or prevent inflammatory responses to subsequent infections. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Mechanistic studies show that expression of wild-type p18, but not a p18(D68N) mutant which cannot inhibit Cdk4/6, down-regulates expression of Cdk4/6 target genes involved in DNA synthesis (TK, TS, DHFR, PCNA) and cell cycle regulation (CDK1 and CCNA2) and thus inhibits reprogramming. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…No mutagenic potential was detected in the Salmonella typhimurium reverse mutation assay (Ames test) or an in vitro mammalian cell gene mutation test using mouse lymphoma L5178Y/TK(+/−) cells (clone 3.7.2C), both with and without metabolic activation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…LO-2 cells were cotransfected with plasmid carrying SR-BI and pRL-TK promoter genes. Promoter activity was measured by the luciferase reporter gene assay. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here established Huh7/NF-κB-tk-luc2/rfp cell line, in which NF-κB indicates a NF-κB promoter, was utilized to noninvasively monitor the expression of NF-κB overtime in vitro and in vivo. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The constitutive overexpression of Tk1‐FEH almost doubled the rubber content in the roots of two dandelion species without any trade‐offs in terms of plant fitness. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Expression of key nucleotide synthesis and proliferation enzymes thymidylate synthase (TS) and thymidine kinase 1 (TK1) was evaluated in differentiated (MITF (high) [microphthalmia‐associated transcription factor] IGR1) and invasive (MITF (medium) IGR37) melanoma cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…By focusing on three RLEs including TK1, TYMS and DTYMK of dTTP biosynthesis pathway, expression of 3 RLEs in well-differentiated HCC cells increased ALDH1(+) and spheroid stemness population but reversed by knockdown in poorly-differentiated HCC cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…EBV reactivation by CytoLytic Virus Activation (CLVA) therapy triggers de novo expression of early viral kinases (PK and TK) and uses antiviral treatment to kill activated cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Then, through the homologous recombination technology and Cre/loxP system, the following gene fragments were gradually knocked out one by one: TC7L-TK2L, TE3L, TA35R, TB13R, and TA66R. Ultimately, the five-segment-deleted attenuated strain MVTT(EAB) was obtained. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Interstitial macrophages (CD64(+) MerTK (+) CD11b(+)) increased significantly as did the percent of CD45(+) Ly6G(+) neutrophils 1 day after the induction of left lung ischemia, despite the fact there was limited cell recruitment due to complete obstruction of the left pulmonary artery in this ischemia model. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…After AOM/DSS treatment, both S100A4-TK mice with the selective depletion of S100A4-expressing cells and S100A4-deficient (S100A4(−/−)) mice developed fewer and smaller tumors than wild-type (WT) control littermates. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso