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221“…Taken together, the study presents a transcriptomic signature for genotoxin exposure in the human TK6 blood cell model. The data demonstrate that responses in different cell models have considerable variations. …”
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222por Jin, Yu-Lan, Yin, Di, Xing, Gang, Huang, Yan-Ming, Fan, Chun-Mei, Fan, Cheng-Fei, Qiu, Xiao-Huo, Dong, Wei-Ren, Yan, Yan, Gu, Jin-Yan, Zhou, Ji-Yong“…These results indicated that the inactivated PRV HD/c vaccine with the deletion of gE/TK genes was a safe and effective PRV vaccine candidate for the control of PRV.…”
Publicado 2022
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223por Zhang, Ju-Feng, Wei, Fang, Wang, Hui-Ping, Li, Hui-Ming, Qiu, Wei, Ren, Peng-Kang, Chen, Xia-Fang, Huang, Qian“…Herpes Simplex Virus Thymidine Kinase (HSV-TK) into oncolytic adenoviral vector to engineer a novel armed oncolytic adenoviral vector 'Ad.hTERT-E1A-TK'. …”
Publicado 2010
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224“…This study aimed to construct a novel recombinant expression vector, pcDNA3.1(-)hTERT-shRNA/yCDglyTK. Its bioactivity and antitumor effects were investigated in the SGC7901 human gastric cancer cell line. …”
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225“…This study aimed to construct a recombinant plasmid pcDNA3.1(-) shCEACAM6-yCDglyTK from CEACAM6 targeting shRNA and the fusion suicide gene yCDglyTK for inhibition of SW1990 human pancreatic carcinoma cell growth and invasion. …”
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226“…Loss of thymidine kinase 2 (TK2) causes a heterogeneous myopathic form of mitochondrial DNA (mtDNA) depletion syndrome (MDS) in humans that predominantly affects skeletal muscle tissue. …”
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227por Xu, Dan, Nishimura, Toshi, Nishimura, Sachiko, Zhang, Haili, Zheng, Ming, Guo, Ying-Ying, Masek, Marylin, Michie, Sara A., Glenn, Jeffrey, Peltz, Gary“…Therefore, we investigated whether FIAU-induced liver toxicity could be detected in chimeric TK-NOG mice with humanized livers. METHODS AND FINDINGS: Control and chimeric TK-NOG mice with humanized livers were treated orally with FIAU 400, 100, 25, or 2.5 mg/kg/d. …”
Publicado 2014
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228por Kumar, J. Kiran, Aronsson, A. C., Pilko, G., Zupan, M., Kumer, K., Fabjan, T., Osredkar, J., Eriksson, S.“…Here, we describe the first clinical results with the newly developed TK 210 ELISA from AroCell AB. Sera from 124 breast cancer patients with known TNM classification along with sera from 53 healthy females were analyzed by TK 210 ELISA for TK1 protein and TK1 activity levels by the (3)[H]-deoxythymidine (dThd) phosphorylation assay. …”
Publicado 2016
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229por Kuo, Wei-Ying, Hwu, Luen, Wu, Chun-Yi, Lee, Jhih-Shian, Chang, Chi-Wei, Liu, Ren-Shyan“…The Lenti-CMV-TK showed ~5 fold higher (3)H-FEAU uptake then Lenti -STAT3-NF-κB-TK. …”
Publicado 2017
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230por Li, Yong-Fang, Yuan, Yang-Yang, Zhang, Ying-Min, Zhao, Na, Zhang, Qi, Meng, Fan-Xiu, Gao, Ran-Peng, Yu, Bao-Feng, Zhang, Yue-Hong, Guo, Rui, Wang, Hai-Long, Xie, Jun, Xu, Jun, Qin, Qin, Dong, Xiu-Shan“…Apoptosis rates in the control group and the pcDNA3.1-pAFP-TK group were (1.00±0.62%) and (38.70±6.03%), respectively. …”
Publicado 2017
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231por Verma, Jatin R., Rees, Benjamin J., Wilde, Eleanor C., Thornton, Catherine A., Jenkins, Gareth J.S., Doak, Shareen H., Johnson, George E.“…A clear increase in MN frequency was observed using the MicroFlow(®) approach on TK6 cells treated for 30 h with MMS, carbendazim and OTA. …”
Publicado 2016
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232por Yun, Hye-Yeoung, Lee, Jinhyuk, Kim, Hyunmin, Ryu, Hyojung, Shin, Ho-Chul, Oh, Byung-Ha, Ku, Bonsu, Kim, Seung Jun“…Here, we present the crystal structures of Tk-PTP derived from the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1, in both the active and inactive forms. …”
Publicado 2018
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233por Li, Hong, Du, Haiyan, Zhang, Guangxian, Wu, Yingya, Qiu, Pengxiang, Liu, Jingjing, Guo, Jing, Liu, Xijuan, Sun, Lingling, Du, Biaoyan, Tan, Yuhui“…Herpes simplex virus thymidine kinase gene with ganciclovir (HSV-TK/GCV) is a promising gene therapy for melanoma. …”
Publicado 2019
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234“…OBJECTIVE: To construct plasmids with Hre(2).Grp78 chimeric promoter regulating fusion gene TK/VP3 and elaborate the effects of overexpressed TK/VP3 on nasopharyngeal carcinoma cells. …”
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235por Nguyen, Ha, Ledent, Maryse, Beauvois, Véronique, Anthonissen, Roel, Verschaeve, Luc, Collard, Jean-Francois, Hinsenkamp, Maurice, Feipel, Veronique, Mertens, Birgit“…In this manuscript, an optimized protocol for a combined in vitro • Optimized protocols for cytogenetic tests with ELF-MFs on TK6 cells ensure the reproducibility of test results. • Validation of exposure environment and exposure system are needed prior to performing tests with ELF-MFs. • A simple, but effective method to shield cells and reduce unintentional ELF-MF exposure consists of using the mu-metal cylinder. …”
Publicado 2020
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236por Faisal, Syed M., Mendez, Flor M., Nunez, Fernando, Castro, Maria G., Lowenstein, Pedro R.“…Immunostimulatory adenoviral-mediated delivery of TK/Flt3L in mice bearing brainstem gliomas resulted in antitumor immunity, recruitment of antitumor-specific T cells, and improved median survival by stimulating the host antitumor immune response. …”
Publicado 2020
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237por Chapman, Katherine E., Wilde, Eleanor C., Chapman, Fiona M., Verma, Jatin R., Shah, Ume-Kulsoom, Stannard, Leanne M., Seager, Anna L., Tonkin, James A., Brown, M. Rowan, Doherty, Ann T., Johnson, George E., Doak, Shareen H., Jenkins, Gareth J. S.“…Endpoints included micronucleus induction, alterations in gene expression, cell cycle dynamics, cell morphology and bioenergetics in the human lymphoblastoid cell line TK6. Carcinogens ochratoxin A and oestradiol produced greater Integrated Signature of Carcinogenicity scores for the combined endpoints than the “misleading” in vitro positive compounds, quercetin, 2,4-dichlorophenol and quinacrine dihydrochloride and toxic non-carcinogens, caffeine, cycloheximide and phenformin HCl. …”
Publicado 2020
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238por Mohd Idrus, Fatin Najiah, Ahmad, Nurul Shuhadah, Hoe, Chee Hock, Azlan, Maryam, Norfuad, Farisha Alia, Yusof, Zurkurnai, Wan Isa, Wan Yus Haniff, Mohamed Ali, Akbar Ali, Yvonne-Tee, Get Bee“…Higher expression of Mer proto-oncogene tyrosine kinase (MerTK) on M2 macrophage helps in maintaining macrophage efferocytic efficiency. …”
Publicado 2021
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239por Tinsel, Iris, Metzner, Gloria, Schlett, Christian, Sehlbrede, Matthias, Bischoff, Martina, Anger, Robin, Brame, Judith, König, Daniel, Wurst, Ramona, Fuchs, Reinhard, Lindinger, Peter, Bredenkamp, Rainer, Farin-Glattacker, Erik“…METHODS: The aim of this study is to test the long-term effectiveness of the web-based TK-HealthCoach with regard to the primary outcomes of increased physical activity, sustainable weight reduction, and smoking abstinence. …”
Publicado 2021
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240“…We show here that mutant RPE lacking MerTK and wild-type RPE deprived of MerTK ligand both fail to form phagocytic cups regardless of Rac1 activation. …”
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