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  1. 2381
    “…In addition, an adenoviral vector with the hON-522E-promoter–driven herpes simplex virus thymidine kinase gene (Ad-522E-TK) was highly effective against the growth of androgen-independent human prostate cancer PC3M and bone stromal cell line in vitro and in pre-established PC3M tumors in vivo upon addition of the prodrug ganciclovir. …”
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    Co-Targeting Prostate Cancer Epithelium and Bone Stroma by Human Osteonectin-Promoter–Mediated Suicide Gene Therapy Effectively Inhibits Androgen-Independent Prostate Cancer Growth
  2. 2382
    “…Previously, using systems biology approach and cancer signaling networks, we identified top-5 highly expressed and connected proteins (HSP90AB1, CSNK2B, TK1, YWHAB and VIM) in the invasive MDA-MB-231 breast cancer cell line. …”
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    Validation of a network-based strategy for the optimization of combinatorial target selection in breast cancer therapy: siRNA knockdown of network targets in MDA-MB-231 cells as an in vitro model for inhibition of tumor development
  3. 2383
    “…These include JQ1 (BET inhibitor), AT101 (Bcl-2 family inhibitor), and sunitinib (TK inhibitor). CONCLUSION: Here, we show data demonstrating the potential of a previously unexplored group of drugs to address an unmet therapeutic need in pediatric oncology. …”
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    The HIV protease inhibitor, nelfinavir, as a novel therapeutic approach for the treatment of refractory pediatric leukemia
  4. 2384
    “…To address the first possibility, we selectively disrupted the proofreading exonuclease activity of DNA polymerase ε (Polε), the leading-strand replicative polymerase in avian DT40 and human TK6 cell lines. To address the second, we disrupted RAD18, a gene involved in translesion DNA synthesis, a mechanism that relieves stalled replication. …”
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    The dominant role of proofreading exonuclease activity of replicative polymerase ε in cellular tolerance to cytarabine (Ara-C)
  5. 2385
    “…Increased Ki67, Ccna2, Ccnb2 and Tk1 expression complemented immunohistochemical evidence of a 3-fold change in cell proliferation. …”
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    Transcription controls growth, cell kinetics and cholesterol supply to sustain ACTH responses
  6. 2386
    “…The purpose of this study was to identify novel therapeutic target TKs and to clarify the efficacy of TK inhibitors (TKIs) in the treatment of ASPS. EXPERIMENTAL DESIGN: To identify novel therapeutic target TKs in ASPS, we evaluated the antitumor effects and kinase activity of three TKIs (pazopanib, dasatinib, and cabozantinib) against ASPS cells using an in vitro assay. …”
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    Cabozantinib and dastinib exert anti-tumor activity in alveolar soft part sarcoma
  7. 2387
    “…The mtDNA content of POLG, DGUOK, TK2, and SUCLA2 genes in blood samples from MDS patients was reduced to 25%, 38%, 32%, and 24%, respectively. …”
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    Reference Intervals of Mitochondrial DNA Copy Number in Peripheral Blood for Chinese Minors and Adults
  8. 2388
    “…SH003, a modified version of traditional herbal medicine extracted from Astragalus membranaceus (Am), Angelica gigas (Ag), and Trichosanthes Kirilowii Maximowicz (Tk) with 1:1:1 ratio (w/w) has been revealed to inhibit tumor growth and metastasis on highly metastatic breast cancer cells, both in vivo and in vitro with no toxicity. …”
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    SH003 suppresses breast cancer growth by accumulating p62 in autolysosomes
  9. 2389
    “…Eight soil properties, pH, soil organic matter (SOM), total and available nitrogen (TN and AN), total and available phosphorus (TP and AP), and total and available potassium (TK and AK), were measured to assess soil quality. …”
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    Soil pH Is the Primary Factor Correlating With Soil Microbiome in Karst Rocky Desertification Regions in the Wushan County, Chongqing, China
  10. 2390
    “…Mathematical models that can mechanistically describe chemical toxicokinetics (TK) and toxicodynamics (TD), for both in vitro and in vivo conditions, are the founding pieces in this regard. …”
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    Bridging the Data Gap From in vitro Toxicity Testing to Chemical Safety Assessment Through Computational Modeling
  11. 2391
    “…The background of the patients and their spinopelvic parameters (pelvic incidence [PI], pelvic tilt [PT], lumbar lordosis [LL], thoracic kyphosis [TK], sagittal vertical axis [SVA], and PI-LL) were evaluated. …”
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    Radiographic and Clinical Outcomes From the Use of S2 Alar Screws in Surgery for Adult Spinal Deformity
  12. 2392
    “…Here we have applied this technology to study protein secretion in the Gram-positive bacterium Streptomyces lividans TK24, a widely used host for heterologous protein secretion biotechnology. …”
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    Monitoring Protein Secretion in Streptomyces Using Fluorescent Proteins
  13. 2393
    “…Among evaluated bDMARDs, anti-TNF agents modulated the polarization of inflammatory macrophages by decreasing inflammatory surface markers (CD40, CD80) and favoring alternative markers (CD16, CD163, MerTK). Anti-TNF agents also induced alternative functions in macrophages activated in inflammatory condition with (i) the inhibition of inflammatory cytokines (TNF, IL-6, IL-12), (ii) an increase in phagocytosis. …”
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    Polarization of Rheumatoid Macrophages by TNF Targeting Through an IL-10/STAT3 Mechanism
  14. 2394
    “…ChIP and global ChIP-seq data also confirms that FOXM1 can also potentially regulate other 5-FU targets, such as TYMS, thymidine kinase 1 (TK-1) and thymidine phosphorylase (TYMP). In human colorectal cancer tissue specimens, a strong correlation of FOXM1 and TYMS staining was observed. …”
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    FOXM1 modulates 5-FU resistance in colorectal cancer through regulating TYMS expression
  15. 2395
    “…Data and scripts to analyze the data are available on the Open Science Framework (OSF) repository: https://osf.io/tk4x5/. Planned analyses are available at https://osf.io/x6g3u/.…”
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    Body Odor Disgust Sensitivity Predicts Moral Harshness Toward Moral Violations of Purity
  16. 2396
    “…In order to increase the efficiency of production, we then expressed the cholesterol oxidase, choD, gene heterologously in Streptomyces lividans TK24 and Streptomyces albus J1074 using two different expression systems. …”
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    Characterization and overproduction of cell-associated cholesterol oxidase ChoD from Streptomyces lavendulae YAKB-15
  17. 2397
    “…The parameters measured included trunk shift and Cobb angle, TK (thoracic kyphosis), TLK (thoraco-lumbar junction kyphosis), LL (lumbar lordosis), PI (pelvic incidence), SS (sacral slope), PT (pelvic tilt) and SVA (sagittal vertical axis). …”
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    Coronal and sagittal spinal alignment in lumbar disc herniation with scoliosis and trunk shift
  18. 2398
    “…Here we describe Endopeptidase 40, a novel glutenase discovered as secreted protein from the soil actinomycete Actinoallomurus A8, and its recombinant active form produced by Streptomyces lividans TK24. E40 is resistant to pepsin and trypsin, and active in the acidic pH range 3 to 6. …”
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    E40, a novel microbial protease efficiently detoxifying gluten proteins, for the dietary management of gluten intolerance
  19. 2399
    “…Increasingly, public health policy makers are employing toxicokinetic (TK) modeling tools to integrate these data streams and predict potential human health impact. …”
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    Advancing internal exposure and physiologically-based toxicokinetic modeling for 21st-century risk assessments
  20. 2400
    “…In this report, we present the cloning and functional characterization of two representatives of the known IMP cyclohydrolase families. The locus TK0430 in Thermococcus kodakarensis encodes a PurO-type IMP cyclohydrolase with demonstrated activity despite its position in a cluster of apparently redundant biosynthetic genes, the first functional characterization of a PurO from a non-methanogen. …”
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    Experimental characterization of two archaeal inosine 5'-monophosphate cyclohydrolases
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