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2421por Allemang, Ashley, De Abrew, K. Nadira, Shan, Yuqing K., Krailler, Jesse M., Pfuhler, Stefan“…Compounds were examined in TK6 cells using an approach in which the same sample was used to evaluate both early genomic markers (Affymetrix analysis 4 hr post treatment), and the genotoxic outcome (micronuclei [MN] after 24 hr). …”
Publicado 2020
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2422por Mawan, Aornpriya, Prakhun, Nonglak, Muisuk, Kanha, Srithawong, Suparat, Srikummool, Metawee, Kampuansai, Jatupol, Shoocongdej, Rasmi, Inta, Angkhana, Ruangchai, Sukhum, Kutanan, Wibhu“…Our overall results indicated homogenous genetic structure within the HM- and Tai-Kadai (TK)-speaking groups, large genetic divergence of the HM-speaking Hmong but not IuMien from the other Thai groups, and genetic heterogeneity within the ST- and AA-speaking groups, reflecting different population interactions and admixtures. …”
Publicado 2021
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2423por Ao, Yue, Yang, Chongrui, Wang, Shengchen, Hu, Qingyi, Yi, Li, Zhang, Jibin, Yu, Ziniu, Cai, Minmin, Yu, Chan“…The nutrient elements (OM, TN, TP, TK and CF) of manure may partly affect the succession of gut bacterial communities with one another, while TN and CF are strongly positively correlated with the relative abundance of Providencia. …”
Publicado 2020
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2424por Ring, Caroline, Sipes, Nisha S., Hsieh, Jui-Hua, Carberry, Celeste, Koval, Lauren E., Klaren, William D., Harris, Mark A., Auerbach, Scott S., Rager, Julia E.“…This study set out to test the hypothesis that in vitro high-throughput screening (HTS) data can more effectively predict in vivo biological responses when chemical disposition and toxicokinetic (TK) modeling are employed. In vitro HTS data from the Tox21 consortium were analyzed in concert with chemical disposition modeling to derive nominal, aqueous, and intracellular estimates of concentrations eliciting 50% maximal activity. …”
Publicado 2021
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2425“…Its genetic cause is a 2.5- to 3.8-kb-long complex pentanucleotide repeat insertion containing (TGGAA)n, (TAGAA)n, (TAAAA)n, and (TAAAATAGAA)n located in an intron shared by two different genes: brain expressed associated with NEDD4-1 (BEAN1) and thymidine kinase 2 (TK2). Among these repeat sequences, (TGGAA)n repeat was the only sequence segregating with SCA31, which strongly suggests its pathogenicity. …”
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2426por Muruzabal, Damián, Sanz-Serrano, Julen, Sauvaigo, Sylvie, Treillard, Bertrand, Olsen, Ann-Karin, López de Cerain, Adela, Vettorazzi, Ariane, Azqueta, Amaya“…Seven genotoxicants with different mechanisms of action (potassium bromate, methyl methanesulfonate, ethyl methanesulfonate, hydrogen peroxide, cisplatin, mitomycin C, and benzo[a]pyrene diol epoxide), as well as a non-genotoxic compound (dimethyl sulfoxide) and a cytotoxic compound (Triton X-100) were tested on TK-6 cells. We were able to detect with high sensitivity and clearly differentiate oxidizing, alkylating and cross-linking agents. …”
Publicado 2021
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2427por Li, Jin-Miao, Kim, Sangbae, Zhang, Yun, Bian, Fang, Hu, Jiaoyue, Lu, Rong, Pflugfelder, Stephen C., Chen, Rui, Li, De-Quan“…The specific expression patterns of RRM2, TK1, CENPF, NUSAP1, UBE2C, and CDC20 were well correlated in a time- and cycle-dependent manner with proliferation stages in the cell growth and regeneration models. …”
Publicado 2021
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2428“…Funding: This study was supported by an Australian Research Council Discovery Early Career Award (TK, DE200100607)…”
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2429“…Tyro3 is a member of the TAM subfamily of receptor tyrosine kinases alongside Axl and MerTK, which are activated by homologous ligands Gas6 and protein S. …”
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2430“…The Protocol addresses access to and benefit sharing (ABS) resulting from utilization of GR and associated traditional knowledge (TK). The Protocol has been tailored to address commercial utilization of mainly wild species, and especially plants, due to their gene flow from the biodiverse rich countries of the South to countries in the North. …”
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2431por Novick, Tessa K., Diaz, Santiago, Barrios, Francisco, Cubas, Doris, Choudhary, Kavyaa, Nader, Paul, ElKhoury, Raymonda, Cervantes, Lilia, Jacobs, Elizabeth A.Enlace del recurso
Publicado 2021
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2432por Chung, Ho Seok, Chung, Jae Lim, Kim, Young Jun, Lee, Hun, Kim, Jae Yong, Tchah, Hungwon“…The IOL power was calculated using conventional formulas (Haigis, SRK/T, Holladay 2, and Barrett Universal II) as well as a new formula (Barrett TK Universal II). The refractive mean error, mean absolute error, and median absolute error were compared, as were the proportions of eyes within ± 0.25 diopters (D), ± 0.50 D, and ± 1.00 D of prediction error. …”
Publicado 2021
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2433por Alghamri, Mahmoud S., McClellan, Brandon L., Avvari, Ruthvik P., Thalla, Rohit, Carney, Stephen, Hartlage, Margaret S., Haase, Santiago, Ventosa, Maria, Taher, Ayman, Kamran, Neha, Zhang, Li, Faisal, Syed Mohd, Núñez, Felipe J., Garcia-Fabiani, María Belén, Al-Holou, Wajd N., Orringer, Daniel, Hervey-Jumper, Shawn, Heth, Jason, Patil, Parag G., Eddy, Karen, Merajver, Sofia D., Ulintz, Peter J., Welch, Joshua, Gao, Chao, Liu, Jialin, Núñez, Gabriel, Hambardzumyan, Dolores, Lowenstein, Pedro R., Castro, Maria G.“…We show that the efficacy of immune-stimulatory gene therapy (TK/Flt3L) is enhanced in mIDH1 gliomas, due to the reprogramming of the myeloid cells’ compartment infiltrating the tumor microenvironment (TME). …”
Publicado 2021
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2434“…Previous work regarding the structural studies of Glt(Ph), Glt(TK), excitatory amino acid transporter 1 (EAAT1), EAAT3 and alanine serine cysteine transporter 2 described the transport mechanism of the glutamate transporter in depth. …”
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2435por Mahida, Rahul Y., Scott, Aaron, Parekh, Dhruv, Lugg, Sebastian T., Belchamber, Kylie B. R., Hardy, Rowan S., Matthay, Michael A., Naidu, Babu, Thickett, David R.“…Expression of AM efferocytosis receptors MerTK (p = 0.015) and CD206 (p = 0.006) increased, whereas expression of the antiefferocytosis receptor SIRPα decreased following ARDS BAL treatment (p = 0.036). …”
Publicado 2021
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2436por Lee, Meelim J., Wang, Chuangqi, Carroll, Molly J., Brubaker, Douglas K., Hyman, Bradley T., Lauffenburger, Douglas A.“…Additionally, we identified agonists of the Tyro3 / Axl / MerTK (TAM) receptor family as significant contributors to the cross-species innate immune signature; the mechanistic roles of the TAM receptor family in AD merit further dedicated study. …”
Publicado 2021
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2437por Klopp, Alexandre, Schreiber, Sophia, Kosinska, Anna D., Pulé, Martin, Protzer, Ulrike, Wisskirchen, Karin“…In this study, T cells were generated by retroviral transduction to express either an HBV-specific chimeric antigen receptor (S-CAR) or T-cell receptor (TCR), and in addition either inducible caspase 9 (iC9) or herpes simplex virus thymidine kinase (HSV-TK) as a safety switch. Real-time cytotoxicity assays using HBV-replicating hepatoma cells as targets revealed that activation of both safety switches stopped cytotoxicity of S-CAR- or TCR-transduced T cells within less than one hour. …”
Publicado 2021
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2438“…Here, we have correlated the maximally induced DNA damage with three test substances in TK6 cells with the survival of the cells. For this, we selected hydrogen peroxide (H(2)O(2)) as an oxidizing agent, methyl methanesulfonate (MMS) as an alkylating agent and etoposide as a topoisomerase II inhibitor. …”
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2439por Ran, Feng, Li, Wendong, Qin, Yi, Yu, Tong, Liu, Zhao, Zhou, Min, Liu, Cheng, Qiao, Tong, Li, Xiaoqiang, Yousef, Reda G., Eissa, Ibrahim H., Khalifa, Mohamed M.“…In order to discover novel VEGFR-2 TK inhibitors, we have designed and synthesized three new series of pyridine-containing compounds. …”
Publicado 2021
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2440por Rahman, Md. Mominur, Junaid, Md., Hosen, S. M. Zahid, Mostafa, Mohammad, Liu, Lei, Benkendorff, Kirsten“…This study evaluates the binding mechanism and potentiality of several brominated indoles (tyrindoxyl sulfate, tyrindoleninone, 6-bromoisatin, and 6,6′-dibromoindirubin) against inflammatory mediators cyclooxygenases-1/2 (COX-1/2) using molecular docking, followed by molecular dynamics simulation, along with physicochemical, drug-likeness, pharmacokinetic (pk), and toxicokinetic (tk) properties. Molecular docking identified that these indole compounds are anchored, with the main amino acid residues, positioned in the binding pocket of the COX-1/2, required for selective inhibition. …”
Publicado 2021
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