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  1. 41
    “…We initially selected 6 fluoropyrimidine metabolism-related genes (DPYD, ORPT, TYMS, TYMP, TK1, and TK2) and 3 radiotherapy response-related genes (GLUT1, HIF-1 α, and HIF-2 α) as targets for gene expression identification in 60 LARC cancer specimens. …”
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    DPYD, TYMS, TYMP, TK1, and TK2 Genetic Expressions as Response Markers in Locally Advanced Rectal Cancer Patients Treated with Fluoropyrimidine-Based Chemoradiotherapy
  2. 42
    por Bianchi, Giovanni
    Publicado 2013
    “…A new CMS tracker is scheduled to become operational for the LHC Phase 2 upgrade in the early 2020's. tkLayout is a software package developed to create 3d models for the design of the CMS tracker and to evaluate its fundamental performance figures. …”
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    tkLayout: a Design Tool for Innovative Silicon Tracking Detectors
  3. 43
    por Parekh, Ramnik
    Publicado 2008
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    Debate on industry influence on OH organizations/T.K. Joshi's tantrums!
  4. 44
    “…H. thermophilus was the first obligate autotrophic organism reported among aerobic hydrogen-oxidizing bacteria. Strain TK-6(T) is of interest because of the unusually efficient hydrogen-oxidizing ability of this strain, which results in a faster generation time compared to other autotrophs. …”
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    Complete genome sequence of Hydrogenobacter thermophilus type strain (TK-6(T))
  5. 45
    “…OBJECTIVE: The efficiency of HSV-tk/GCV system is not high because of insufficient gene transfer and incompletely initiative of host antineoplastic potency. …”
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    Enforced effect of tk-MCP-1 fusion gene in ovarian cancer
  6. 46
    “…MerTK targeted shRNA completely prevented intracranial and subcutaneous glioma growth further delineating the impact of MerTK inhibition on glioblastoma. …”
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    MerTK inhibition is a novel therapeutic approach for glioblastoma multiforme
  7. 47
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    Discovery of a series of novel phenylpiperazine derivatives as EGFR TK inhibitors
  8. 48
    “…We determined a crystal structure of Glt(Tk) with bound D-aspartate at 2.8 Å resolution. …”
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    Binding and transport of D-aspartate by the glutamate transporter homolog Glt(Tk)
  9. 49
    “…SUMMARY: The Genome Taxonomy Database Toolkit (GTDB-Tk) provides objective taxonomic assignments for bacterial and archaeal genomes based on the GTDB. …”
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    GTDB-Tk: a toolkit to classify genomes with the Genome Taxonomy Database
  10. 50
    “…Our goal was to analyze post mortem tissues of an adult patient with late-onset thymidine kinase 2 (TK2) deficiency who died of respiratory failure. …”
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    Preferent Diaphragmatic Involvement in TK2 Deficiency: An Autopsy Case Study
  11. 51
    “…It is well-established that the secondary active transporters Glt(Tk) and Glt(Ph) catalyze coupled uptake of aspartate and three sodium ions, but insight in the kinetic mechanism of transport is fragmentary. …”
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    Kinetic mechanism of Na(+)-coupled aspartate transport catalyzed by Glt(Tk)
  12. 52
    “…Increased expression of TK1 is associated with the progression of a variety of tumors. …”
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    Comprehensive Analysis of Immune-Related Prognosis of TK1 in Hepatocellular Carcinoma
  13. 53
    “…Background: It has been reported that thymidine kinase 1 (TK1) was up-regulated in multiple malignancies and participated in the regulation of tumor malignant behavior. …”
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    Assessing the Potential Prognostic and Immunological Role of TK1 in Prostate Cancer
  14. 54
    “…BACKGROUND AND PURPOSE: Bruton's TK (BTK) is a non‐receptor kinase best known for its role in B lymphocyte development that is critical for proliferation and survival of leukaemic cells in B‐cell malignancies. …”
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    Bruton's TK regulates myeloid cell recruitment during acute inflammation
  15. 55
    “…TK1 is overexpressed in numerous cancers and is associated with to a poor prognosis. …”
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    Methylation status of TK1 correlated with immune infiltrates in prostate cancer
  16. 56
    “…Therefore, In order to reduce the GCV dose required, we aim to compare the therapeutic efficacy of HSV1-sr39TK, an HSV1-TK mutant with increased GCV prodrug catalytic activity, with wildtype TK in C6 glioma cells. …”
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    Gene Therapy with HSV1-sr39TK/GCV Exhibits a Stronger Therapeutic Efficacy Than HSV1-TK/GCV in Rat C6 Glioma Cells
  17. 57
    “…BACKGROUND: HSV-tk/ ganciclovir (GCV) gene therapy has been extensively studied in the setting of brain tumors and largely relies on the bystander effect. …”
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    Dexamethasone inhibits the HSV-tk/ ganciclovir bystander effect in malignant glioma cells
  18. 58
    por Clive, D
    Publicado 1973
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    Recent developments with the L5178Y TK heterozygote mutagen assay system.
  19. 59
    “…However, the addition of the OMV-fraction collected from TK1402 could enhance biofilm formation. CONCLUSION: The results suggested that OMV produced from TK1402 play an important role in biofilm formation in strain TK1402.…”
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    Outer Membrane Vesicles of Helicobacter pylori TK1402 are Involved in Biofilm Formation
  20. 60
    “…The herpes simplex virus thymidine kinase (HSV-TK) is the most widely used suicide gene in cancer gene therapy due to its superior anticancer activity with ganciclovir compared to other HSV-TK substrates, such as 1-β-D-arabinofuranosyl thymine (araT). …”
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    Unrepairable DNA Double Strand Breaks Initiate Cytotoxicity with HSV-TK/Ganciclovir
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