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41por Huang, Ming-Yii, Wu, Chan-Han, Huang, Chun-Ming, Chung, Fu-Yen, Huang, Ching-Wen, Tsai, Hsiang-Lin, Chen, Chin-Fan, Lin, Shiu-Ru, Wang, Jaw-Yuan“…We initially selected 6 fluoropyrimidine metabolism-related genes (DPYD, ORPT, TYMS, TYMP, TK1, and TK2) and 3 radiotherapy response-related genes (GLUT1, HIF-1 α, and HIF-2 α) as targets for gene expression identification in 60 LARC cancer specimens. …”
Publicado 2013
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42por Bianchi, Giovanni“…A new CMS tracker is scheduled to become operational for the LHC Phase 2 upgrade in the early 2020's. tkLayout is a software package developed to create 3d models for the design of the CMS tracker and to evaluate its fundamental performance figures. …”
Publicado 2013
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44por Zeytun, Ahmet, Sikorski, Johannes, Nolan, Matt, Lapidus, Alla, Lucas, Susan, Han, James, Tice, Hope, Cheng, Jan-Fang, Tapia, Roxanne, Goodwin, Lynne, Pitluck, Sam, Liolios, Konstantinos, Ivanova, Natalia, Mavromatis, Konstantinos, Mikhailova, Natalia, Ovchinnikova, Galina, Pati, Amrita, Chen, Amy, Palaniappan, Krishna, Ngatchou-Djao, Olivier D., Land, Miriam, Hauser, Loren, Jeffries, Cynthia D., Han, Cliff, Detter, John C., Übler, Susanne, Rohde, Manfred, Tindall, Brian J., Göker, Markus, Wirth, Reinhard, Woyke, Tanja, Bristow, James, Eisen, Jonathan A., Markowitz, Victor, Hugenholtz, Philip, Klenk, Hans-Peter, Kyrpides, Nikos C.“…H. thermophilus was the first obligate autotrophic organism reported among aerobic hydrogen-oxidizing bacteria. Strain TK-6(T) is of interest because of the unusually efficient hydrogen-oxidizing ability of this strain, which results in a faster generation time compared to other autotrophs. …”
Publicado 2011
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45por Hong, Shuhui, Zhang, Ping, Zhang, Hui, Jia, Lin, Qu, Xun, Yang, Qifeng, Rong, Fengnian, Kong, Beihua“…OBJECTIVE: The efficiency of HSV-tk/GCV system is not high because of insufficient gene transfer and incompletely initiative of host antineoplastic potency. …”
Publicado 2012
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46por Knubel, Kristina H., Pernu, Ben M., Sufit, Alexandra, Nelson, Sarah, Pierce, Angela M., Keating, Amy K.“…MerTK targeted shRNA completely prevented intracranial and subcutaneous glioma growth further delineating the impact of MerTK inhibition on glioblastoma. …”
Publicado 2014
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48por Arkhipova, Valentina, Trinco, Gianluca, Ettema, Thijs W, Jensen, Sonja, Slotboom, Dirk J, Guskov, Albert“…We determined a crystal structure of Glt(Tk) with bound D-aspartate at 2.8 Å resolution. …”
Publicado 2019
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49“…SUMMARY: The Genome Taxonomy Database Toolkit (GTDB-Tk) provides objective taxonomic assignments for bacterial and archaeal genomes based on the GTDB. …”
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50por Laine-Menéndez, Sara, Domínguez-González, Cristina, Blázquez, Alberto, Delmiro, Aitor, García-Consuegra, Inés, Fernández-de la Torre, Miguel, Hernández-Laín, Aurelio, Sayas, Javier, Martín, Miguel Ángel, Morán, María“…Our goal was to analyze post mortem tissues of an adult patient with late-onset thymidine kinase 2 (TK2) deficiency who died of respiratory failure. …”
Publicado 2021
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51por Trinco, Gianluca, Arkhipova, Valentina, Garaeva, Alisa A., Hutter, Cedric A. J., Seeger, Markus A., Guskov, Albert, Slotboom, Dirk J.“…It is well-established that the secondary active transporters Glt(Tk) and Glt(Ph) catalyze coupled uptake of aspartate and three sodium ions, but insight in the kinetic mechanism of transport is fragmentary. …”
Publicado 2021
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52por Cai, Qun, Zhu, Mingyan, Duan, Jinnan, Wang, Hao, Chen, Jingdan, Xiao, Yixin, Wang, Yangqin, Wang, Jianfang, Yu, Xuewen, Yang, Hui“…Increased expression of TK1 is associated with the progression of a variety of tumors. …”
Publicado 2022
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53por Xie, Hui, Guo, Linpei, Wang, Zhun, Peng, Shuanghe, Ma, Qianwang, Yang, Zhao, Shang, Zhiqun, Niu, Yuanjie“…Background: It has been reported that thymidine kinase 1 (TK1) was up-regulated in multiple malignancies and participated in the regulation of tumor malignant behavior. …”
Publicado 2022
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54“…BACKGROUND AND PURPOSE: Bruton's TK (BTK) is a non‐receptor kinase best known for its role in B lymphocyte development that is critical for proliferation and survival of leukaemic cells in B‐cell malignancies. …”
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55“…TK1 is overexpressed in numerous cancers and is associated with to a poor prognosis. …”
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56por Li, Lei-qing, Shen, Fang, Xu, Xiao-yan, Zhang, Hong, Yang, Xiao-feng, Liu, Wei-guo“…Therefore, In order to reduce the GCV dose required, we aim to compare the therapeutic efficacy of HSV1-sr39TK, an HSV1-TK mutant with increased GCV prodrug catalytic activity, with wildtype TK in C6 glioma cells. …”
Publicado 2013
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57por Robe, Pierre A, Nguyen-Khac, Minh, Jolois, Olivier, Rogister, Bernard, Merville, Marie-Paule, Bours, Vincent“…BACKGROUND: HSV-tk/ ganciclovir (GCV) gene therapy has been extensively studied in the setting of brain tumors and largely relies on the bystander effect. …”
Publicado 2005
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59por Yonezawa, Hideo, Osaki, Takako, Kurata, Satoshi, Fukuda, Minoru, Kawakami, Hayato, Ochiai, Kuniyasu, Hanawa, Tomoko, Kamiya, Shigeru“…However, the addition of the OMV-fraction collected from TK1402 could enhance biofilm formation. CONCLUSION: The results suggested that OMV produced from TK1402 play an important role in biofilm formation in strain TK1402.…”
Publicado 2009
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60“…The herpes simplex virus thymidine kinase (HSV-TK) is the most widely used suicide gene in cancer gene therapy due to its superior anticancer activity with ganciclovir compared to other HSV-TK substrates, such as 1-β-D-arabinofuranosyl thymine (araT). …”
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