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  1. 721
    “…The cytosolic thymidine kinase 1 (TK1) is one of the enzymes involved in DNA replication. …”
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    Investigation on Cell Proliferation with a New Antibody against Thymidine Kinase 1
  2. 722
    “…Tachykinin (TK) families, including the first neuropeptide substance P, have been intensively explored in bilaterians. …”
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    Multiple tachykinins and their receptors characterized in the gastropod mollusk Pacific abalone: Expression, signaling cascades, and potential role in regulating lipid metabolism
  3. 723
    “…BACKGROUND: Thymidine kinase 1 (TK1) is a salvage enzyme involved in DNA precursor synthesis, and its expression is proliferation dependent. …”
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    Quaternary structures of recombinant, cellular, and serum forms of Thymidine Kinase 1 from dogs and humans
  4. 724
    por Wilkinson, Henry C., Dalby, Paul A.
    Publicado 2020
    “…We recently characterised a low-activity form of E. coli transketolase, TK(low), which also binds the cofactor thiamine pyrophosphate (TPP) with an affinity up to two-orders of magnitude lower than the previously known high TPP-affinity and high-activity form, TK(high), in the presence of Mg(2+). …”
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    The Two-Species Model of transketolase explains donor substrate-binding, inhibition and heat-activation
  5. 725
    “…Thymidine kinase 1 (TK1) phosphorylates thymidine nucleosides to generate thymidine monophosphate. …”
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    Maize Thymidine Kinase Activity Is Present throughout Plant Development and Its Heterologous Expression Confers Tolerance to an Organellar DNA-Damaging Agent
  6. 726
    “…Thymidine kinase 1 (TK1) is a DNA precursor enzyme whose expression is closely correlated with cell proliferation and cell turnover. …”
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    A New Sandwich ELISA for Quantification of Thymidine Kinase 1 Protein Levels in Sera from Dogs with Different Malignancies Can Aid in Disease Management
  7. 727
    “…Thymidine kinase 1 (TK1) is an intracellular enzyme involved in DNA-precursor synthesis. …”
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    Prediction of Overall Survival by Thymidine Kinase 1 Combined with Prostate-Specific Antigen in Men with Prostate Cancer
  8. 728
    “…The protumorigenic role of TK1 has been reported in various malignancies. However, the role of TK1 in skin cutaneous melanoma (SKCM) remains unclear. …”
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    Thymidine Kinase 1 Drives Skin Cutaneous Melanoma Malignant Progression and Metabolic Reprogramming
  9. 729
    “…However, it remains unknown whether TK1 is essential for FTD incorporation into DNA and whether this event is affected by the expression level of TK1 because TK1-specific-deficient human cancer cell lines have not been established. …”
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    Cytotoxicity of trifluridine correlates with the thymidine kinase 1 expression level
  10. 730
    “…The elevated expression of thymidine kinase 1 (TK1) has been implicated in the progression of thyroid carcinoma, while the role of TK1 in thyroid carcinoma progression has not been explored. …”
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    Knockdown of Thymidine Kinase 1 Suppresses Cell Proliferation, Invasion, Migration, and Epithelial–Mesenchymal Transition in Thyroid Carcinoma Cells
  11. 731
    “…Three stably transfected cell lines (HepG2/pSURV, HepG2/TK/pSURV and HepG2/TAT-TK/pSURV) were successfully established. …”
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    Suicide gene therapy for hepatocellular carcinoma cells by survivin promoter-driven expression of the herpes simplex virus thymidine kinase gene
  12. 732
    “…No such correlation was observed with mononuclear leukocyte TK levels. Serum TK from 20 patients with breast cancer and 19 control patients was further assayed to ascertain the relative contributions of the thymidine kinase isozymes TK1 and TK2 to total TK levels. …”
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    Thymidine kinase activities in mononuclear leukocytes and serum from breast cancer patients.
  13. 733
    “…METHODS: Anti-TK1 monoclonal antibodies were produced against two different epitopes, the active site of the TK1 protein and the C-terminal region of canine TK1. …”
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    A monoclonal antibody-based sandwich ELISA for measuring canine Thymidine kinase 1 protein and its role as biomarker in canine lymphoma
  14. 734
    “…However, recent studies targeting TK1 at protein and mRNA levels have shown that TK1 may be useful as a therapeutic target. …”
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    Selection of human single domain antibodies (sdAb) against thymidine kinase 1 and their incorporation into sdAb-Fc antibody constructs for potential use in cancer therapy
  15. 735
    “…Taijin-Kyofu-sho (TK) is regarded as a culture-bound anxiety disorder in East Asian counties. …”
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    Correlation between Taijin-Kyofu-sho and Attention Deficit Hyperactivity Disorder among University Students: A Self-Reported Assessment Study
  16. 736
    “…In cancer cells TK1 is upregulated and excess TK1 is leaked into the blood. …”
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    Feline thymidine kinase 1: molecular characterization and evaluation of its serum form as a diagnostic biomarker
  17. 737
    “…In a retrospective study design, we explored the relationship between serum thymidine kinase 1 (TK1) concentration before radiotherapy and clinical parameters and evaluated the prognostic value of serum TK1 concentration before radiotherapy in breast cancer patients with type 2 diabetes mellitus. …”
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    Relationship between thymidine kinase 1 before radiotherapy and prognosis in breast cancer patients with diabetes
  18. 738
    “…To develop an in vivo screening system for potential cancer drugs targeting specific EGFR mutants, we expressed three LET-23 chimeras in which the TK domain was replaced with either the human wild-type TK domain (LET-23::hEGFR-TK), a TK domain with the L858R mutation (LET-23::hEGFR-TK[L858R]), or a TK domain with the T790M-L858R mutations (LET-23::hEGFR-TK[T790M-L858R]) in C. elegans vulval cells using the let-23 promoter. …”
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    An In Vivo C. elegans Model System for Screening EGFR-Inhibiting Anti-Cancer Drugs
  19. 739
    “…We generated lentiviral vectors encoding the wild-type herpes simplex virus thymidine kinase (HSV-TK) gene and a gene containing a point mutation that results in an alanine to histidine substitution at residue 168 (TK(A168H)) and transduced expression in MSCs (MSC-TK and MSC-TK(A168H)). …”
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    Improving the Safety of Mesenchymal Stem Cell-Based Ex Vivo Therapy Using Herpes Simplex Virus Thymidine Kinase
  20. 740
    “…RESULTS: On gamma counter-analyses, counts/minute (cpm)/µg of protein showed MOIs dependency with ΔE1B19/55-TK infection. On MTT assay, Ad-ΔE1B19/55-TK led to more efficient cell killing than Ad-ΔE1A-TK. …”
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    Imaging of Viral Thymidine Kinase Gene Expression by Replicating Oncolytic Adenovirus and Prediction of Therapeutic Efficacy
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