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  1. 741
    “…The subject was considered to match with the formula, if the difference between the virtual TK and the theoretical TK was less than 10°. Then regression analysis was performed to establish a new formula to predict TK in adolescents. …”
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    Could pelvic parameters determine optimal postoperative thoracic kyphosis in Lenke type 1 AIS patients?
  2. 742
    “…The mean absolute error (MAE) was 0.424, 0.671, 0.638, 0.439, 0.408, 0.424, 0.479, 0.647, and 0.524, and median absolute error (MedAE) was 0.388, 0.586, 0.605, 0.298, 0.294, 0.324, 0.333, 0.438, and 0.377 for Barrett True-K, Haigis-L, Shammas-PL, Barrett True-K TK, EVO with TK, Haigis with TK, Hoffer Q with TK, Holladay I with TK, and SRK/T with TK, respectively. …”
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    Accuracy of intraocular lens formulas using total keratometry in eyes with previous myopic laser refractive surgery
  3. 743
    “…While canonical TK2 was conserved among vertebrates, TK2-EXT was specific to primates. …”
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    Thymidine Kinase 2 and Mitochondrial Protein COX I in the Cerebellum of Patients with Spinocerebellar Ataxia Type 31 Caused by Penta-nucleotide Repeats (TTCCA)(n)
  4. 744
    “…OBJECTIVE: The purpose of the study was to explore the anti-tumor effect of ultrasound -targeted microbubble destruction mediated herpes simplex virus thymidine kinase (HSV-TK) suicide gene system on mice hepatoma. METHODS: Forty mice were randomly divided into four groups after the models of subcutaneous transplantation tumors were estabilished: (1) PBS; (2) HSV-TK (3) HSV-TK+ ultrasound (HSV-TK+US); (4) HSV-TK+ultrasound+microbubbles (HSV-TK+US+MB). …”
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    Ultrasound-targeted microbubble destruction mediated herpes simplex virus-thymidine kinase gene treats hepatoma in mice
  5. 745
    “…Thymidine kinase 2 (TK2) deficiency in humans causes mitochondrial DNA (mtDNA) depletion syndrome. …”
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    Thymidine Kinase 2 Deficiency-Induced mtDNA Depletion in Mouse Liver Leads to Defect β-Oxidation
  6. 746
    “…Adding the wild-type HSV-tk gene might disrupt the tumor selectivity of VV-tk deleted OVVs; therefore, only engineered viruses that lacked tk activity were selected as candidates. …”
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    Engineering and Characterization of Oncolytic Vaccinia Virus Expressing Truncated Herpes Simplex Virus Thymidine Kinase
  7. 747
    “…In this study, we explore the possible use of TK1 in Hodgkin lymphoma (HL). METHODS: Serum concentrations of TK1 (S-TK1) were measured in 46 newly diagnosed HL patients using prospectively collected biobanked serum samples. …”
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    Serum concentrations of Thymidine kinase 1 measured using a novel antibody-based assay in patients with Hodgkin Lymphoma
  8. 748
    “…TK(1-4), TK(5-8), and TK(9-12) had a similar negative correlation with PI-LL; however, TK(5-8) had the strongest correlation (r=−0.38). …”
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    Upper Thoracic Compensation against Global Malalignment and Spinopelvic Mismatch in Adult Spinal Deformity Patients Analyzed Using the EOS Imaging System
  9. 749
    “…BACKGROUND: Previous studies have reported that rod composition and diameter, as well as the correction technique are key factors associated with thoracic kyphosis (TK) restoration. However, few study has analyzed the correlation between screw density and TK restoration in hypokyphotic adolescent idiopathic scoliosis (AIS). …”
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    Influence of screw density on thoracic kyphosis restoration in hypokyphotic adolescent idiopathic scoliosis
  10. 750
    “…High resolution mass spectrometry with Pseudomonas aeruginosa PAO1 and its tk variant (PAO1TK) confirmed FIAU phosphorylation and retention only in PAO1TK. …”
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    Bioengineering of bacterial pathogens for noninvasive imaging and in vivo evaluation of therapeutics
  11. 751
    “…However, the clinical application of TK on diabetic patients and the hypoglycemic efficacies of TK are still unclear. …”
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    Hypoglycemic effects of Trichosanthes kirilowii and its protein constituent in diabetic mice: the involvement of insulin receptor pathway
  12. 752
    “…Vaccinia virus TK is a close orthologue of variola TK but also shares a relatively high sequence identity to human type 2 TK (hTK), thus achieving drug selectivity relative to the host enzyme is challenging. …”
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    Structure of vaccinia virus thymidine kinase in complex with dTTP: insights for drug design
  13. 753
    “…TK's best-established substrate is Tcap, a small structural protein of the Z-disc believed to link TK to myofibrillogenesis. …”
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    Titin kinase is an inactive pseudokinase scaffold that supports MuRF1 recruitment to the sarcomeric M-line
  14. 754
    “…The herpes simplex virus thymidine kinase/ganciclovir (HSV TK/GCV) system is one of the best studied cancer suicide gene therapy systems. …”
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    Intravenous Administration Is an Effective and Safe Route for Cancer Gene Therapy Using the Bifidobacterium-Mediated Recombinant HSV-1 Thymidine Kinase and Ganciclovir
  15. 755
    “…In this study, pTK‐internal ribosome entry site (IRES), pIRES‐ES, and pTK‐IRES‐ES plasmids were constructed; pIRES empty vector served as the negative control. …”
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    Antitumor activity of combined endostatin and thymidine kinase gene therapy in C6 glioma models
  16. 756
    “…Deficiency in thymidine kinase 2 (TK2) causes mitochondrial DNA depletion. Liver mitochondria are severely affected in Tk2 complete knockout models and have been suggested to play a role in the pathogenesis of the Tk2 knockout phenotype, characterized by loss of hypodermal fat tissue, growth retardation and reduced life span. …”
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    Long term survival and abnormal liver fat accumulation in mice with specific thymidine kinase 2 deficiency in liver tissue
  17. 757
    “…The efficiency of cell killing monitored by assessing Rluc (CAL62/Rluc) and Fluc (MSC-Tet-TK/Fluc and MSC-TK/Fluc) activities using IVIS imaging. …”
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    Genetically engineered suicide gene in mesenchymal stem cells using a Tet-On system for anaplastic thyroid cancer
  18. 758
    por Ran, Xiao, Zhang, Qin, Wang, Dao Wen
    Publicado 2015
    “…Aim. Tissue kallikrein (TK) protein content in plasma has been shown to be negatively associated with both incident and recurrent strokes. …”
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    Tissue Kallikrein Activity, Detected by a Novel Method, May Be a Predictor of Recurrent Stroke: A Case-Control Study
  19. 759
    “…The cytopathic effect of Adv‐TK‐F/K20 in U‐87MG and U‐373MG cells was approximately 140 and 40 times, respectively, stronger than that of Adv‐TK. …”
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    Transduction of a Fiber‐mutant Adenovirus for the HSVtk Gene Highly Augments the Cytopathic Effect towards Gliomas
  20. 760
    “…Hens were immunized with 31-peptide, a key sequence of human TK1 (hTK1), before constructing an immune phage display scFv library. …”
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    Development of a Novel Recombinant Full-Length IgY Monoclonal Antibody against Human Thymidine Kinase 1 for Automatic Chemiluminescence Analysis on a Sandwich Biotin-Streptavidin Platform for Early Tumour Discovery
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