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Mostrando 781 - 800 Resultados de 2,825 Para Buscar '"TK"', tiempo de consulta: 0.25s Limitar resultados
  1. 781
    “…AIM: Tissue kallikrein (TK) exerts protective effects on cardiac cerebrovascular diseases (CCVDs). …”
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    Decreased Tissue Kallikrein Levels and the Risk of Ischemic Stroke: A Community-Based Cross-Sectional Study in China
  2. 782
    “…Data mining was used to screen the core herbs of the TK. Network pharmacology was used to predict the antihypertensive mechanism of TK core herbs. …”
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    Traditional Chinese medicine method of tonifying kidney for hypertension: Clinical evidence and molecular mechanisms
  3. 783
    “…Here, we show that thymidine kinase 1 (TK1) is significantly overexpressed in tumor samples from lung adenocarcinoma (LUAD) patients relative to normal controls, and this TK1 overexpression is associated with significantly reduced overall survival and cancer recurrence. …”
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    Loss of thymidine kinase 1 inhibits lung cancer growth and metastatic attributes by reducing GDF15 expression
  4. 784
    “…CONCLUSION: When the regulatory network of LINC00665/has-let-7b-5p/TK1 was assessed, it was observed that elevated TK1 levels may affect the prognosis of NSCLC. …”
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    Thymidine kinase 1 as a target is regulated by the hsa-let-7b-5p/LINC00665 axis and affects NSCLC prognosis
  5. 785
    “…The one-year PFS and OS were 35.7% and 50.0% in ADV-TK group respectively. ADV-TK/ganciclovir gene therapy was well tolerated, and no treatment-related severe adverse events were noted. …”
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    Adenovirus-mediated delivery of herpes simplex virus thymidine kinase administration improves outcome of recurrent high-grade glioma
  6. 786
    “…Each individual took full spine X-ray to evaluate pelvic incidence (PI), pelvic tilt (PT), sacral slope (SS), lumbar lordosis (LL), thoracic kyphosis (TK), TK+LL+PI, TK/LL, and sacrum-femoral-pubic symphysis (SFP). …”
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    Radiological analysis for thoracolumbar disc herniation in spinopelvic sagittal alignment: A retrospective study
  7. 787
    “…CONCLUSIONS: Reciprocal change in TK after lumbar spine correction is correlated to preoperative TK and age.…”
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    Postoperative Change of Thoracic Kyphosis after Corrective Surgery for Adult Spinal Deformity
  8. 788
    “…[Image: see text] Biomass can be upgraded via torrefaction, and torrefied kenaf (TK) is a fuel that allows blending with coal at high ratios. …”
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    Comparative Study of the Synergistic Effects of Blending Raw/Torrefied Biomass and Vietnamese Anthracite Using Co-pyrolysis
  9. 789
    por Ou, Wu, Li, Pingjuan, Reiser, Jakob
    Publicado 2013
    “…The other six clones were GCV-sensitive, but the TK gene was located at off-target sites. These TK-expressing hiPSC clones remained GCV sensitive for up to 90 days, indicating that TK transgene expression was stable. …”
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    Targeting of Herpes Simplex Virus 1 Thymidine Kinase Gene Sequences into the OCT4 Locus of Human Induced Pluripotent Stem Cells
  10. 790
    “…Co-culture resistant cells expressing HSV-TK and cells stably transduced with VSV-G showed that expression of VSV-G could promote the bystander killing effect of HSV-TK/GCV. …”
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    Vesicular Stomatitis Virus G Glycoprotein and ATRA Enhanced Bystander Killing of Chemoresistant Leukemic Cells by Herpes Simplex Virus Thymidine Kinase/Ganciclovir
  11. 791
    “…L. major Type II TK (LmTK) has been previously shown to be important for infectivity of the parasite and therefore has potential as a drug target for anti-leishmanial therapy. …”
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    Structural and Kinetic Characterization of Thymidine Kinase from Leishmania major
  12. 792
    “…There was no difference in endogenous TK levels in plasma at 6 months postoperatively between the TK and control groups. …”
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    Tissue Kallikrein Prevents Restenosis After Stenting of Severe Atherosclerotic Stenosis of the Middle Cerebral Artery: A Randomized Controlled Trial
  13. 793
    por Chen, Y, Le, Q, Hong, J, Gong, L, Xu, J
    Publicado 2017
    “…PURPOSE: To explore the morphological characteristics of toxic keratopathy (TK), which clinically presented as superficial punctate keratopathy (SPK), with the application of in vivo laser-scanning confocal microscopy (LSCM), and evaluate its potential in the early diagnosis of TK. …”
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    In vivo confocal microscopy of toxic keratopathy
  14. 794
    “…Viral replication of thymidine kinase deleted (tk(−)) vaccinia virus (VV) is attenuated in resting normal cells, enabling cancer selectivity, however, replication potency of VV-tk(−) appears to be diminished in cancer cells. …”
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    Engineering and Preclinical Evaluation of Western Reserve Oncolytic Vaccinia Virus Expressing A167Y Mutant Herpes Simplex Virus Thymidine Kinase
  15. 795
    “…This study describes the biochemical and molecular characterisation of a novel and unusual hyperthermophilic TK from Thermotoga maritima DSM3109 (TK(tmar)). …”
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    Characterisation of a hyperthermophilic transketolase from Thermotoga maritima DSM3109 as a biocatalyst for 7-keto-octuronic acid synthesis
  16. 796
    “…These three recombinant viruses with US3 codon de-optimization ((PRV(ΔTK&gE-US3deop−1), PRV(ΔTK&gE-US3deop−2), and PRV(ΔTK&gE-US3deop−3)) were obtained and purified. …”
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    A Novel Strategy of US3 Codon De-Optimization for Construction of an Attenuated Pseudorabies Virus against High Virulent Chinese Pseudorabies Virus Variant
  17. 797
    “…In the TK gene mutation assay, the cytotoxic and mutagenic sensitivities of KO TK+/- cells were higher than those of WT TK+/- cells. …”
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    DNA polymerase kappa protects human cells against MMC-induced genotoxicity through error-free translesion DNA synthesis
  18. 798
    “…For our study, we designed the Tet-On system using a retroviral vector and developed a response plasmid RetroX-TRE (tetracycline response element) expressing a mutant form of herpes simplex virus thymidine kinase (HSV1-sr39TK) with dual reporters (eGFP-Fluc2). Bone marrow-derived MSCs were transduced using a RetroX-Tet3G (Clontech, CA, USA) regulatory plasmid and RetroX-TRE-HSV1-sr39TK-eGFP-IRES-Fluc2, for a system with a Tet-On (MSC-Tet-TK/Fluc2 or MSC-Tet-TK) or without a Tet-On (MSC-TK/Fluc2 or MSC-TK) function. …”
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    Regulated Mesenchymal Stem Cells Mediated Colon Cancer Therapy Assessed by Reporter Gene Based Optical Imaging
  19. 799
    “…Replication-competent adenoviruses armed with thymidine kinase (TK) combine the concepts of virotherapy and suicide gene therapy. …”
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    Oncolytic Adenoviruses Armed with Thymidine Kinase Can Be Traced by PET Imaging and Show Potent Antitumoural Effects by Ganciclovir Dosing
  20. 800
    “…Autosomal recessive mutations in the thymidine kinase 2 gene (TK2) cause mitochondrial DNA depletion, multiple deletions, or both due to loss of TK2 enzyme activity and ensuing unbalanced deoxynucleotide triphosphate (dNTP) pools. …”
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    Deoxypyrimidine monophosphate bypass therapy for thymidine kinase 2 deficiency
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