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801por Lee, Sangmin, Jia, Baolei, Liu, Jinliang, Pham, Bang Phuong, Kwak, Jae Myeong, Xuan, Yuan Hu, Cheong, Gang-Won“…Thermococcus kodakaraensis KOD1, an anaerobic archaeon, contains many antioxidant proteins, including three Prxs (Tk0537, Tk0815, and Tk1055). Only Tk0537 has been found to be induced in response to heat, osmotic, and oxidative stress. …”
Publicado 2015
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802“…Furthermore, of the 96 patients, 36 (37.5%) were positive for both TK1 protein and CK19 mRNA, 30 (31.3%) were negative for TK1 protein, and 15 (15.6%) were negative for TK1 protein and positive for CK19 mRNA. …”
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803por Ran, Xiao, Zhang, Qin, Li, Shaoping, Yu, Zhen, Wan, Li, Wu, Bin, Wu, Rongxue, Li, Shusheng“…With a septic model of TK and kallistatin in vitro, we found that TK exacerbated sepsis-induced endothelial hyperpermeability by downregulating zonula occluden-1 (ZO-1) and vascular endothelial (VE)-cadherin, and these could be reversed by kallistatin, an inhibitor of TK. …”
Publicado 2021
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804por Wesolowski, Carl Adam, Ling, Lin, Xirouchakis, Elias, Burniston, Maria T., Puetter, Richard C., Babyn, Paul S., Giamalis, Ioannis G., Burroughs, Andrew K.“…PURPOSE: The aim was to compare late-time extrapolation of plasma clearance (CL) from Tikhonov adaptively regularized gamma variate fitting (Tk-GV) and from mono-exponential (E1) fitting. METHODS: Ten (51)Cr-ethylenediaminetetraacetic acid bolus IV studies in adults—8 with ascites—assessed for liver transplantation, with 12–16 plasma samples drawn from 5-min to 24-h, were fit with Tk-GV and E1 models and CL results were compared using Passing-Bablok fitting. …”
Publicado 2011
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805“…RESULTS: TK, AS, SO, and XS enhanced the proliferation of 22Rv1 cells without having cytotoxic effects. …”
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806por Shi, Cunzhen, Li, Xiangqun, Wang, Xiaogan, Ding, Ning, Ping, Lingyan, Shi, Yunfei, Mi, Lan, Lai, Yumei, Song, Yuqin, Zhu, Jun“…This study assessed the role of MerTK in MCL for the first time. METHODS: Immunohistochemistry and western blot were performed to figure out expression of MerTK in MCL. …”
Publicado 2018
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807por Boyé, Pierre, Floch, Franck, Serres, François, Geeraert, Kévyn, Clerson, Pierre, Siomboing, Xavier, Bergqvist, Mattias, Sack, Gabriel, Tierny, Dominique“…BACKGROUND: Serum thymidine kinase 1 (sTK1) activity is closely correlated with DNA synthesis. …”
Publicado 2019
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808por Zhang, Qin, Tan, Juan, Wan, Li, Chen, Chao, Wu, Bin, Ke, Xijian, Wu, Rongxue, Ran, Xiao“…Although tissue kallikrein (TK) has used in the treatment of stroke in China, the role of TK in modulating BBB permeability is not clear. …”
Publicado 2021
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809por Wang, Ziyang, Song, Yanzheng, Yang, Wenli, Li, Dongjun, Chen, Wei, Zhao, Qi, Liu, Qian, Zhai, Changbin“…The changes of biological parameters, including SK, posterior keratometry (PK), and TK, and the difference between SK and TK were compared. …”
Publicado 2022
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810“…The Tk-GV model fits Gamma Variates (GV) to data by Tikhonov regularization (Tk) with shrinkage constant, λ, chosen to minimize the relative error in plasma clearance, CL (ml/min). …”
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811por Fu, Shen Shen, Li, Fu Ji, Wang, Yuan Yuan, You, An Bei, Qie, Yi Liang, Meng, Xiao, Li, Jian Rui, Li, Bao Chuan, Zhang, Yun, Da Li, Qing“…BACKGROUND: Human tissue kallikrein (hTK) plays an essential role in the physiological and pathological mechanisms of blood vessels. …”
Publicado 2013
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812por Szánthó, Eszter, Bhattoa, Harjit Pal, Csobán, Mária, Antal-Szalmás, Péter, Újfalusi, Anikó, Kappelmayer, János, Hevessy, Zsuzsanna“…In CLL patients, TK1 activity was the highest in the advanced Rai stages. …”
Publicado 2014
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813por Yao, Yuyu, Sheng, Zulong, Li, Yefei, Fu, Cong, Ma, Genshan, Liu, Naifeng, Chao, Julie, Chao, Lee“…Endothelial progenitor cells (EPCs) have been shown to enhance angiogenesis not only by incorporating into the vasculature but also by secreting cytokines, thereby serving as an ideal vehicle for gene transfer. As tissue kallikrein (TK) has pleiotropic effects in inhibiting apoptosis and oxidative stress, and promoting angiogenesis, we evaluated the salutary potential of kallikrein-modified human EPCs (Ad.hTK-hEPCs) after acute myocardial infarction (MI). …”
Publicado 2013
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814por Mitterreiter, Johanna G., Titulaer, Maarten J., van Nierop, Gijsbert P., van Kampen, Jeroen J. A., Aron, Georgina I., Osterhaus, Albert D. M. E., Verjans, Georges M. G. M., Ouwendijk, Werner J. D.“…Acyclovir (ACV) is the antiviral treatment of choice, but may lead to emergence of ACV-resistant (ACV(R)) HSV due to mutations in the viral UL23 gene encoding for the ACV-targeted thymidine kinase (TK) protein. Here, we determined the prevalence of intrathecal ACV(R)–associated HSV TK mutations in HSE patients and compared TK genotypes of sequential HSV isolates in paired cerebrospinal fluid (CSF) and blister fluid of mucosal HSV lesions. …”
Publicado 2016
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815“…The pAcGFP1-Hyg-TK-CD plasmid was transfected into HTFs, and reverse-transcription polymerase chain reaction (RT-PCR) was used to detect TK-CD expression. …”
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816por Bonechi, Martina, Galardi, Francesca, Biagioni, Chiara, De Luca, Francesca, Bergqvist, Mattias, Neumüller, Magnus, Guarducci, Cristina, Boccalini, Giulia, Gabellini, Stefano, Migliaccio, Ilenia, Di Leo, Angelo, Pestrin, Marta, Malorni, Luca“…Patients with low baseline levels of TK1 activity had a significantly better PFS compared to those with high baseline TK1 activity (p-value=0.012). …”
Publicado 2018
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817por Larsson, Anna-Maria, Bendahl, Pär-Ola, Aaltonen, Kristina, Jansson, Sara, Forsare, Carina, Bergqvist, Mattias, Jørgensen, Charlotte Levin Tykjær, Rydén, Lisa“…The aim of this study was to evaluate serum TK1 activity (sTK1) levels in MBC patients as a tool for prognostication and treatment monitoring. 142 women with MBC scheduled for 1(st) line systemic treatment were included in a prospective observational study. sTK1 was measured at baseline (BL) and at 1, 3 and 6 months and correlations to progression-free and overall survival (PFS, OS) evaluated. …”
Publicado 2020
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818Inactive-to-Active Transition of Human Thymidine Kinase 1 Revealed by Molecular Dynamics Simulations“…[Image: see text] Despite its importance in the nucleoside (and nucleoside prodrug) metabolism, the structure of the active conformation of human thymidine kinase 1 (hTK1) remains elusive. We perform microsecond molecular dynamics simulations of the inactive enzyme form bound to a bisubstrate inhibitor that was shown experimentally to activate another TK1-like kinase, Thermotoga maritima TK (TmTK). …”
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819por Wang, Changdong, Ma, Yongping, Hu, Qiongwen, Xie, Tingting, Wu, Jiayan, Zeng, Fan, Song, Fangzhou“…However, BF-rTK + GCV did not result in necroptosis and autophagy. …”
Publicado 2016
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820por Adamová, D., Aglieri Rinella, G., Agnello, M., Ahammed, Z., Aleksandrov, D., Alici, A., Alkin, A., Alt, T., Altsybeev, I., Andreou, D., Andronic, A., Antinori, F., Antonioli, P., Appelshäuser, H., Arnaldi, R., Arsene, I.C., Arslandok, M., Averbeck, R., Azmi, M.D., Bai, X., Bailhache, R., Bala, R., Barioglio, L., Barnaföldi, G.G., Barnby, L.S., Bartalini, P., Barth, K., Basu, S., Becattini, F., Bedda, C., Belikov, I., Bellini, F., Bellwied, R., Beole, S., Bergmann, L., Bertens, R.A., Besoiu, M., Betev, L., Bhatti, A., Bianchi, A., Bianchi, L., Bielčík, J., Bielčíková, J., Bilandzic, A., Biswas, S., Biswas, R., Blau, D., Bock, F., Bombara, M., Borri, M., Braun-Munzinger, P., Bregant, M., Bruno, G.E., Buckland, M.D., Buesching, H., Bufalino, S., Buncic, P., Butt, J.B., Caliva, A., Camerini, P., Carnesecchi, F., Castillo Castellanos, J., Catalano, F., Chapeland, S., Chartier, M., Cheshkov, C., Cheynis, B., Chibante Barroso, V., Chinellato, D.D., Chochula, P., Chujo, T., Cicalo, C., Colamaria, F., Colella, D., Concas, M., Conesa del Valle, Z., Contin, G., Contreras, J.G., Costa, F., Dönigus, B., Dahms, T., Dainese, A., Dainton, J., Danu, A., Das, S., Das, D., Dash, S., Dash, A., David, G., De Caro, A., de Cataldo, G., De Falco, A., De Marco, N., De Pasquale, S., Deb, S., Di Bari, D., Di Mauro, A., Dietel, T., Divià, R., Dmitrieva, U., Dobrin, A., Dubey, A.K., Dubla, A., Elia, D., Erazmus, B., Erokhin, A., Eulisse, G., Evans, D., Fabbietti, L., Faggin, M., Fecchio, P., Feliciello, A., Feofilov, G., Fernández Téllez, A., Festanti, A., Floerchinger, S., Foka, P., Fokin, S., Franco, A., Furget, C., Furs, A., Gaardhøje, J., Gagliardi, M., Ganoti, P., Garabatos, C., Garcia-Solis, E., Gargiulo, C., Gasik, P., Gay Ducati, M.B., Germain, M., Ghosh, P., Giubellino, P., Giubilato, P., Glässel, P., Gonzalez, V., Grachov, O., Grigoryan, A., Grigoryan, S., Grosa, F., Grosse-Oetringhaus, J.F., Guernane, R., Gunji, T., Gupta, R., Gupta, A., Habib, M.K., Hamagaki, H., Harris, J.W., Hatzifotiadou, D., Heckel, S.T., Hellbär, E., Helstrup, H., Herman, T., Hillemanns, H., Hills, C., Hippolyte, B., Hornung, S., Hristov, P., Iddon, J.P., Igolkin, S., Innocenti, G., Ippolitov, M., Ivanov, M., Jacholkowski, A., Jung, M., Jusko, A., Köhler, M.K., Kabana, S., Kalweit, A., Karasu Uysal, A., Karavicheva, T., Kebschull, U., Keidel, R., Keil, M., Ketzer, B., Khan, S.A., Khanzadeev, A., Kharlov, Y., Khuntia, A., Kim, B., Kim, J., Kim, M., Klein, J., Klein, C., Klein-Bösing, C., Klewin, S., Kluge, A., Knichel, M.L., Kobdaj, C., Kofarago, M., Konopka, P.J., Kovalenko, V., Králik, I., Krüger, M., Kreis, L., Krivda, M., Krizek, F., Kroesen, M., Kryshen, E., Kučera, V., Kuhn, C., Kumar, L., Kundu, S., Kushpil, S., Kweon, M.J., Kwon, M., Kwon, Y., Lévai, P., La Pointe, S.L., Laudi, E., Lazareva, T., Lea, R., Leardini, L., Lee, S., Lemmon, R.C., Lietava, R., Lim, B., Lindenstruth, V., Lindner, A., Lippmann, C., Liu, J., Lopez Lopez, J., Lourenco, C., Luparello, G., Mahmood, S.M., Maire, A., Manzari, V., Mao, Y., Marín, A., Marchisone, M., Margagliotti, G.V., Marquard, M., Martinengo, P., Masciocchi, S., Masera, M., Masson, E., Mastroserio, A., Mathis, A.M., Matyja, A., Mazzilli, M., Mazzoni, M.A., Micheletti, L., Mishra, A.N., Miskowiec, D., Mohanty, B., Mohisin Khan, M., Morsch, A., Mrnjavac, T., Muccifora, V., Mühlheim, D., Muhuri, S., Mulligan, J.D., Munhoz, M.G., Munzer, R.H., Murakami, H., Musa, L., Naik, B., Nandi, B.K., Nania, R., Nayak, T.K., Nesterov, D., Nicosia, G., Nikolaev, S., Nikulin, V., Noferini, F., Norman, J., Nyanin, A., Okorokov, V., Oppedisano, C., Otwinowski, J., Oyama, K., Pł oskoń, M., Pachmayer, Y., Pandey, A.K., Pastore, C., Pawlowski, J., Pei, H., Peitzmann, T., Peresunko, D., Petrovici, M., Pezzi, R.P., Piano, S., Prakasa, E., Prasad, S.K., Preghenella, R., Prino, F., Pruneau, C.A., Pshenichnov, I., Puccio, M., Pucek, J., Quercigh, E., Röhrich, D., Ramello, L., Rami, F., Raniwala, S., Raniwala, R., Rath, R., Ravasenga, I., Redelbach, A., Redlich, K., Reidt, F., Reygers, K., Riabov, V., Riedler, P., Riegler, W., Rischke, D., Ristea, C., Rode, S.P., Rodríguez Cahuantzi, M., Rohr, D., Rossi, A., Rui, R., Rustamov, A., Rybicki, A., Šafařík, K., Sadikin, R., Sadovsky, S., Sahoo, R., Sahoo, P., Sahu, P.K., Saini, J., Samsonov, V., Sarma, P., Scheid, H.S., Schicker, R., Schmah, A., Schmidt, M.O., Schmidt, C., Schutz, Y., Schweda, K., Scomparin, E., Seger, J.E., Senyukov, S., Seryakov, A., Shahoyan, R., Sharma, N., Siddhanta, S., Siemiarczuk, T., Singh, R., Sitta, M., Soltveit, H., Spyropoulou-Stassinaki, M., Stachel, J., Sugitate, T., Sumowidagdo, S., Sun, X., Takahashi, J., Terrevoli, C., Toia, A., Topilskaya, N., Tripathy, S., Trogolo, S., Trubnikov, V., Trzaska, W.H., Trzeciak, B.A., Tveter, T.S., Uras, A., Usai, G.L., Valentino, G., van Doremalen, L.V.R., van Leeuwen, M., Vande Vyvre, P., Vasileiou, M., Vechernin, V., Vermunt, L., Villalobos Baillie, O., Virgili, T., Vodopyanov, A., Voloshin, S.A., Volpe, G., von Haller, B., Vorobyev, I., Wang, Y., Weber, M., Wegrzynek, A., Weiser, D.F., Wenzel, S.C., Wessels, J.P., Wiechula, J., Wiedemann, U., Wilkinson, J., Windelband, B., Winn, M., Xu, N., Yamakawa, K., Yin, Z., Yoo, I.-K., Yoon, J.H., Yuncu, A., Zaccolo, V., Zampolli, C., Zarochentsev, A., Zhang, B., Zhang, X., Zhao, C., Zherebchevskii, V., Zhou, D., Zhou, Y., Zhou, Y., Zinovjev, G.Enlace del recurso
Publicado 2019