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Mostrando 881 - 900 Resultados de 2,825 Para Buscar '"TK"', tiempo de consulta: 0.23s Limitar resultados
  1. 881
    “…OBJECTIVES: This study aimed to evaluate content quality and racial/ethnic representation, particularly of high‐risk cohorts, of prostate cancer screening videos on YouTube (YT) and TikTok (TK). MATERIALS AND METHODS: The top 50 videos populated for the search term ‘prostate cancer screening’ on YT and TK that met inclusion criteria were retrieved in a cache‐cleared browser. …”
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    Accuracy of prostate cancer screening recommendations for high‐risk populations on YouTube and TikTok
  2. 882
    “…Recent reports suggest that TK oncogenic signaling is also under the control of small adaptor proteins. …”
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    The role of small adaptor proteins in the control of oncogenic signaling driven by tyrosine kinases in human cancer
  3. 883
    por Yu, Jau-Song
    Publicado 2019
    “…Thus, identification of dysregulated TK(s) in a specific cancer type and development of TK inhibitors (TKIs) that can potently block activity of the dysregulated TK establish the foundation of modern targeted cancer therapies. …”
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    From discovery of tyrosine phosphorylation to targeted cancer therapies: The 2018 Tang Prize in Biopharmaceutical Science
  4. 884
    por Zhao, He, Chen, Xu, Liu, Bo, Liu, Xi, Liu, Yong
    Publicado 2023
    “…The MAEs and MedAEs showed no difference between most of the K-based and the TK-based formula; only the MAE of TK was significantly higher than that of K using the Haigis. …”
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    Accuracy of refractive outcomes using standard or total keratometry for intraocular lens power formulas in conventional cataract surgery
  5. 885
    “…Like many other new psychoactive substances, NSOs are consumed without any preclinical safety data or any knowledge on toxicokinetic (TK) data. Due to ethical reasons, controlled human TK studies cannot be performed for the assessment of these relevant data. …”
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    Toxicokinetics of U-47700, tramadol, and their main metabolites in pigs following intravenous administration: is a multiple species allometric scaling approach useful for the extrapolation of toxicokinetic parameters to humans?
  6. 886
    “…BACKGROUND/AIM: To explore the therapeutic effects of thymidine kinase (TK) expressed by enhanced vector pGL3-basic- hTERTp-TK-EGFP-CMV driven by human telomerase reverse transcriptase promoter (hTERTp) as well as cytomegalovirus immediate early promoter enhancer (CMV). …”
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    Targeted gene therapy of nasopharyngeal cancer in vitro and in vivo by enhanced thymidine kinase expression driven by human TERT promoter and CMV enhancer
  7. 887
    “…From 500-ns MD simulation, the structural stability of VF16 in complex with EGFR-TK was quite stable, suggesting that this compound could be a novel small molecule inhibitor targeting EGFR-TK.…”
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    Identification of Vinyl Sulfone Derivatives as EGFR Tyrosine Kinase Inhibitor: In Vitro and In Silico Studies
  8. 888
    “…However, when administered separately only Tk decreased both allodynia. The effect of Tk was shown to be mediated by the spinal noradrenergic system as intrathecal pretreatment with α(1)- and α(2)-adrenergic-receptor antagonists (prazosin and idazoxan), but not 5-HT(1/2), and 5-HT(3)-receptor antagonists (methysergide and MDL-72222) blocked the effect of Tk. …”
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    Analgesic Effect of SH003 and Trichosanthes kirilowii Maximowicz in Paclitaxel-Induced Neuropathic Pain in Mice
  9. 889
    “…BACKGROUND: Thymidine kinase 1 (TK1) recycles DNA before cell division. We do not know if baseline blood concentrations of TK1 predict death in prostate cancer within 30 years. …”
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    Serum thymidine kinase 1 concentration as a predictive biomarker in prostate cancer
  10. 890
    “…Focus group interviews were conducted after 6 months of use and thematically analyzed to gain deeper insight into the user experience. Log files of the TK were used to evaluate the number of visits to the TK, the total duration of time spent in the TK, and information on intervention completion. …”
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    Users’ Experiences With the NoHoW Web-Based Toolkit With Weight and Activity Tracking in Weight Loss Maintenance: Long-term Randomized Controlled Trial
  11. 891
    “…Although erlotinib, a potent EGFR tyrosine kinase (EGFR-TK) inhibitor, has been used as the first-line drug for lung cancer treatment, acquired drug resistance caused by the T790M secondary mutation of EGFR-TK inevitably develops after a median response duration of 9–13 months. …”
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    Sulfonylated Indeno[1,2-c]quinoline Derivatives as Potent EGFR Tyrosine Kinase Inhibitors
  12. 892
    “…In order to appraise the presence of cells belonging to cardiovascular and haematopoietic lineages, specific markers were analysed by quantitative PCR, whole mount in situ hybridization and immunofluorescence. Transduction with TK(+) hFGFR1 or the TK(+) Y766F-hFGFR1 mutant rescued cardiomyocyte beating foci formation in fgfr1(−/−) EBs whereas the TK(−) Y653/654F-hFGFR1 mutant and the TK(+) Y463F-hFGFR1 mutant were both ineffective. …”
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    Fibroblast growth factor receptor-1 phosphorylation requirement for cardiomyocyte differentiation in murine embryonic stem cells
  13. 893
    “…However, this trend was not observed in the TK group. Clearance adaptations were present in both limb loss groups. …”
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    Walking kinematics in young children with limb loss using early versus traditional prosthetic knee prescription protocols
  14. 894
    “…TK-cystatin gene was expressed in Escherichia coli. …”
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    Bioinformatics analysis and characterization of a secretory cystatin from Thelohanellus kitauei
  15. 895
    “…The indices that were significantly different between the two groups were preoperative PT, PI minus LL, TK, TPA, TK compensation, and postoperative T10-L2 angle. …”
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    Risk Factors for Proximal Junctional Kyphosis in Fusions from the Sacrum to L1 or L2 for Adult Spinal Deformity
  16. 896
    “…Herein, we showed that a neuronal tachykinin-like receptor at 86C (TkR86C) is required for the repair of non-innervated wing discs in Drosophila. …”
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    Involvement of neuronal tachykinin-like receptor at 86C in Drosophila disc repair via regulation of kynurenine metabolism
  17. 897
    “…Complete regression of the tumors was observed after multiple AAV‐tk injections followed by intraperitoneal ganciclovir (GCV) administration, and the survival of mice treated with AAV‐tk vector and GCV administration was markedly prolonged. …”
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    Adeno‐associated Virus Vector Containing the Herpes Simplex Virus Thymidine Kinase Gene Causes Complete Regression of Intracerebrally Implanted Human Gliomas in Mice, in Conjunction with Ganciclovir Administration
  18. 898
    “…Furthermore, Ad-hTK1/hTIMP1 significantly enhanced proliferation, migration and tube formation in H/R-treated CMVECs. …”
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    Co-expression of tissue kallikrein 1 and tissue inhibitor of matrix metalloproteinase 1 improves myocardial ischemia-reperfusion injury by promoting angiogenesis and inhibiting oxidative stress
  19. 899
    “…OBJECTIVE: Loss of lumbar lordosis (LL) in degenerative deformity activates spinal compensatory mechanisms to maintain neutral C7 sagittal vertical axis (C7SVA), such as an increase in pelvic tilt (PT) and decreased thoracic kyphosis (TK). We study the extent to which PT increase and TK reduction contribute to the compensation of pelvic incidence (PI)-LL mismatch. …”
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    Compensatory mechanisms in adult degenerative thoracolumbar spinal deformity – Radiographic patterns, their reversibility after corrective surgery, and the influence of pelvic morphology
  20. 900
    “…The results showed that the TK and LL values for a person with SCI in a dependent seated posture were greater than those of normal subjects for: standing (by TK: 6.8° ± 1.6°; LL: 21.2° ± 1.9°), sitting straight (by TK: 10.0° ± 4.0°; LL: 1.7° ± 2.6°), and relaxed sitting (by TK: 3.9° ± 0.3°; LL: 7.7° ± 1.4°), respectively, indicating an increased risk for spinal deformity. …”
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    Sagittal Spinal Alignment in People with Chronic Spinal Cord Injury and Normal Individual: A Comparison Study Using 3D Ultrasound Imaging
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