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Mostrando 941 - 960 Resultados de 2,825 Para Buscar '"TK"', tiempo de consulta: 0.22s Limitar resultados
  1. 941
    “…In the presence of exogenously administered valganciclovir, new neurons expressing TK undergo apoptosis. Female B6 nestin-TK mice (n = 80) were evaluated for neurogenesis reduction as a positive control. …”
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    Evaluation of a C57BL/6J x 129S1/SvImJ Hybrid Nestin-Thymidine Kinase Transgenic Mouse Model for Studying the Functional Significance of Exercise-Induced Adult Hippocampal Neurogenesis
  2. 942
    “…The present study investigated the activity and mechanisms regulated by PARP-1 during HQ-induced apoptosis using TK6 lymphoblastoid cells and PARP-1-silenced TK6 cells. …”
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    PARP-1 may be involved in hydroquinone-induced apoptosis by poly ADP-ribosylation of ZO-2
  3. 943
    “…There are two major isoforms of NTRK2 (neurotrophic receptor tyrosine kinase 2, or TrkB), full-length isoform with tyrosine kinase (TK) domain intact (+) and spliced isoform without tyrosine kinase domain (TK(−)). …”
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    3′UTRs Regulate Mouse Ntrk2 mRNA Distribution in Cortical Neurons
  4. 944
    “…BACKGROUND: Antemortem definitive diagnosis of lymphoma in horses is often difficult. Thymidine kinase 1 (TK1) assay is a potentially useful biomarker for lymphoma in horses. …”
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    Clinical performance of a commercially available thymidine kinase 1 assay for diagnosis of lymphoma in 42 hospitalized horses (2017‐2020)
  5. 945
    “…Neck pain positively correlated with TK and LL sagittal standing. Low back pain correlated with LL sagittal standing flexion and TK sagittal standing extension. …”
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    The Impact of Internal Compensatory Mechanisms on Musculoskeletal Pain in Elite Polish Sitting Volleyball Players – a Preliminary Study
  6. 946
    “…The results revealed that each TNBC subtype expressed distinct TK genes that were specific to the TNBC subtype. …”
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    Transcriptomic Analysis of Subtype-Specific Tyrosine Kinases as Triple Negative Breast Cancer Biomarkers
  7. 947
    por Gwak, So-Jung, Lee, Jeoung Soo
    Publicado 2019
    “…We also show that PgP/pHSV-TK with GCV treatment showed significantly higher anticancer activity in C6 cells compared to PgP/pHSV-TK without GCV treatment. …”
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    Suicide Gene Therapy By Amphiphilic Copolymer Nanocarrier for Spinal Cord Tumor
  8. 948
    “…We searched for a TK-based GES associated with disease-free survival (DFS) and tested its robustness in an independent validation set. …”
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    A Tyrosine Kinase Expression Signature Predicts the Post-Operative Clinical Outcome in Triple Negative Breast Cancers
  9. 949
    “…RESULTS: There were a total of 321 patients in the TK group and 1031 patients in the NSTEMI group. …”
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    Takotsubo Cardiomyopathy and Non-ST-Segment Elevation Myocardial Infarction: Predictors of Left Ventricular Dysfunction
  10. 950
    “…Thymidine kinase 2 (TK2) deficiency in humans leads to a myopathic form of mitochondrial DNA (mtDNA) deficiency. …”
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    Mitochondrial dysfunction is associated with lipid metabolism disorder and upregulation of angiotensin-converting enzyme 2
  11. 951
    “…Through the CCM approach, TK not only assures the best possible care for its insurees, but also safeguards its long-term financial sustainability…”
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    Continuous Case Management of a German Statutory Health Insurance
  12. 952
    “…Furthermore, patients in the observational group had much larger TK (post‐TK, P = 0.015). The optimal threshold for post‐TK (sensitivity = 85.7%, specificity = 76.7%; AUC = 0.823, 95% CI [0.672–0.974]) was 28.1° after the ROC curve was analyzed. …”
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    Correlation of Acetabular Anteversion and Thoracic Kyphosis Postoperatively with Proximal Junctional Failure in Adult Spinal Deformity Fused to Pelvis
  13. 953
    “…Moreover, by comparing the transcriptomes of different TKS lines, we identified 25 TkMADSs related to biomass formation and 4 TkMADSs related to NR content, which represented new targets for improving the NR yield of TKS.…”
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    Genome-Wide Identification of MADS-Box Genes in Taraxacum kok-saghyz and Taraxacum mongolicum: Evolutionary Mechanisms, Conserved Functions and New Functions Related to Natural Rubber Yield Formation
  14. 954
    “…Imatinib mesylate, a BCR-ABL TK inhibitor, is the frontline therapy for CML. …”
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    Dasatinib in chronic myeloid leukemia: a review
  15. 955
    “…The bystander effect is an intriguing phenomenon by which adjacent cells become sensitized to drug treatment during gene therapy with herpes simplex virus thymidine kinase/ganciclovir (HSV-tk/GCV). This effect is reported to be mediated by gap junctional intercellular communication (GJIC), and therefore, we postulated that upregulation of genes that facilitate GJIC may enhance the HSV-tk/GCV bystander effect. …”
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    Tanshinone IIA Increases the Bystander Effect of Herpes Simplex Virus Thymidine Kinase/Ganciclovir Gene Therapy via Enhanced Gap Junctional Intercellular Communication
  16. 956
    “…This strategy to obtain TK-defective BoHV-5 may be useful to study the role of TK in BoHV-5 neuropathogenesis and for vaccine development.…”
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    Selection and characterization of brivudin resistant bovine herpesvirus type 5
  17. 957
    “…This study has chosen Adv-TK, the well-established adjuvant treatment in cancer, and compared its efficacy and safety with those of the two newly synthesized oncolytic adenovirus vectors encoding the HSV-TK gene, namely M7 and M8. …”
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    A Systematic Comparison of the Anti-Tumoural Activity and Toxicity of the Three Adv-TKs
  18. 958
    “…To investigate the expression and clinical significance of trans-membrane MerTK (mMer) on circulating CD14+ monocytes/macrophages and soluble MerTK (sMer) levels in plasma in systemic lupus erythematosus (SLE). …”
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    The Expression and Clinical Significance of Different Forms of Mer Receptor Tyrosine Kinase in Systemic Lupus Erythematosus
  19. 959
    “…Notably, culture conditions promoting TK alterations were also effective in increasing active BACE1 levels. …”
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    Altered Proteolysis in Fibroblasts of Alzheimer Patients with Predictive Implications for Subjects at Risk of Disease
  20. 960
    “…Stable transfectant of human colorectal HCT8 cells was established which expressed hypoxia-inducible vectors (HRE-TK/eGFP and HRE-CD/UPRT/mDsRed). Hypoxia-induced expression/function of TK, CD and UPRT was verified by western blot analysis, flow cytometry, fluorescent microscopy and cytotoxicity assay of GCV and 5-FC. …”
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    Hypoxia-targeted triple suicide gene therapy radiosensitizes human colorectal cancer cells
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