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  1. 81
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    Novel Anticancer Fused Pyrazole Derivatives as EGFR and VEGFR-2 Dual TK Inhibitors
  2. 82
    “…An especially early onset form of RP with blindness in teenage years is caused by mutations in mertk, the gene encoding the clearance phagocytosis receptor Mer tyrosine kinase (MerTK). The cause for blindness in mutant MerTK-associated RP (mutMerTK-RP) is the failure of retinal pigment epithelial cells in diurnal phagocytosis of spent photoreceptor outer segment debris. …”
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    Microglia Inhibition Delays Retinal Degeneration Due to MerTK Phagocytosis Receptor Deficiency
  3. 83
    “…Rhizobium ruizarguesonis (Rhizobium leguminosarum) strain 1TK341 was isolated from pink nodules of fixation-negative mutant line P61 of pea (Pisum sativum L.) grown in soil. …”
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    Draft Genome Sequence of Rhizobium ruizarguesonis (Rhizobium leguminosarum) Strain 1TK341
  4. 84
    “…The Tyro, Axl, and MerTK receptors (TAMRs) play a significant role in the clearance of apoptotic cells. …”
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    Targeted Phagocytosis Induction for Cancer Immunotherapy via Bispecific MerTK-Engaging Antibodies
  5. 85
    “…The TkSRPP gene was highly expressed under hormones and wound-induced conditions. …”
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    Functional Characterization of TkSRPP Promoter in Response to Hormones and Wounding Stress in Transgenic Tobacco
  6. 86
    “…Here, we demonstrated practical laboratory tools for monitoring of BCR-ABL1 transcripts in chronic myeloid leukemia patients undergoing TK inhibitor therapy. METHODS: Real time quantitative PCR and direct sequencing were performed for monitoring of BCR-ABL1 transcripts in 245 treated CML. …”
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    Practical Laboratory Tools for Monitoring of BCR-ABL1 Transcripts and Tyrosine Kinase (TK) Domain Mutations in Chronic Myeloid Leukemia Patients Undergoing TK Inhibitor Therapy: A Single-Center Experience in Thailand
  7. 87
    “…BACKGROUND: Thymidine kinase 1 (TK1) is a cellular enzyme involved in DNA precursor synthesis, and its activity has been used as a proliferation marker for monitoring malignant diseases. …”
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    Breast and prostate cancer patients differ significantly in their serum Thymidine kinase 1 (TK1) specific activities compared with those hematological malignancies and blood donors: implications of using serum TK1 as a biomarker
  8. 88
    por de Man, Sven
    Publicado 1999
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    Design of a new oil distribution system for the new booster EK and TK kicker generators
  9. 89
    por De Man, Sven
    Publicado 1999
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    Design of a new oil distribution system for the new booster EK and TK kicker generators
  10. 90
    “…By qRT-PCR, flow cytometry, and Western blot, we detected greater MerTK expression in M2 than M1 macrophages. Targeting MerTK with antibody Mer590 decreased LNCaP efferocytosis by M2 HMDMs, establishing the role of MerTK in prostate cancer efferocytosis. …”
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    Targeting MerTK decreases efferocytosis and increases anti-tumor immune infiltrate in prostate cancer
  11. 91
    por Lifang, Yang, Min, Tang, Midan, Ai, Ya, Cao
    Publicado 2008
    “…RESULTS: The activation of TK was increased after transfection of the pVLTR-tk into the EBV-LMP1 positive cells. …”
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    HSV-tk/GCV gene therapy mediated by EBV-LMP1 for EBV-associated cancer
  12. 92
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    Correction: Effect of Chemical Mutagens and Carcinogens on Gene Expression Profiles in Human TK6 Cells
  13. 93
    “…Furthermore, intraperitoneal injection of HPV-16 pseudovirions carrying the HSV-tk gene followed by treatment with ganciclovir led to significant therapeutic anti-tumor effects in murine ovarian cancer-bearing mice. …”
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    Ovarian Cancer Gene Therapy Using HPV-16 Pseudovirion Carrying the HSV-tk Gene
  14. 94
    “…Stimulation of MerTK by the ligand Gas6 led to activation of the prosurvival proteins Erk 1/2 and Stat5, and MerTK-dependent activation of the STAT pathway in leukemia represents a novel finding. …”
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    Inhibition of MerTK increases chemosensitivity and decreases oncogenic potential in T-cell acute lymphoblastic leukemia
  15. 95
    “…TK1 deficiency has for a long time been known to cause increased cellular sensitivity to DNA damage. …”
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    FISH comets show that the salvage enzyme TK1 contributes to gene-specific DNA repair
  16. 96
    “…Comamonas testosteroni TK102 (NBRC 109938; JCM 19603) can utilize biphenyl as a sole carbon source and degrade polychlorinated biphenyls (PCBs). …”
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    Complete Genome Sequence of Polychlorinated Biphenyl Degrader Comamonas testosteroni TK102 (NBRC 109938)
  17. 97
    “…Code and documentation for the NifTK platform are available from http://www.niftk.org. …”
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    The NifTK software platform for image-guided interventions: platform overview and NiftyLink messaging
  18. 98
    “…Here we solve crystal structures of the archaeal transporter Glt(Tk) in the presence and absence of aspartate and use molecular dynamics simulations and binding assays to show how strict coupling between the binding of three sodium ions and aspartate takes place.…”
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    Coupled binding mechanism of three sodium ions and aspartate in the glutamate transporter homologue Glt(Tk)
  19. 99
    “…Biological data for most of the anthranilate diamide showed excellent activity with nanomolar or sub nanomolar half maximal inhibitory concentration (IC(50)) values against tumor cells. EGFR tyrosine kinase (TK) inhibition assay, tubulin inhibition assay and apoptosis analysis were performed for selected compounds to get more details about their mechanism of action. …”
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    The Design and Development of Potent Small Molecules as Anticancer Agents Targeting EGFR TK and Tubulin Polymerization
  20. 100
    “…After homologous recombination with a transfer vector, a TK&gE dual deficient mutant PRV (PRV(ΔTK&gE-AH02)) was generated, and its structure verified by PCR, RFLP and sequencing. …”
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    Safety and immunogenicity of an attenuated Chinese pseudorabies variant by dual deletion of TK&gE genes
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