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1061“…This review describes the enhancement of pulmonary fibrosis by VEGFR1-TK signal and suggests that the blocking of the VEGFR1-TK signal may be useful for the treatment of pulmonary fibrosis.…”
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1062“…The chemical structure of the TK fibre was confirmed by Fourier-transform infrared spectroscopy (FT-IR) analysis. …”
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1063Publicado 1985“…The bacteriophage SP6 promoter and RNA polymerase were used to synthesize sense and antisense RNAs coding for the enzymes thymidine kinase (TK) and chloramphenicol acetyl transferase (CAT). …”
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1064“…In colorectal cancer (CRC), it is still unclear how aberrant TK activities contribute to tumour formation because TK-encoding genes are not frequently mutated in this cancer. …”
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1065por de Fuenmayor-Fernández de la Hoz, Carlos Pablo, Morís, Germán, Jiménez-Mallebrera, Cecilia, Badosa, Carmen, Hernández-Laín, Aurelio, Blázquez Encinar, Alberto, Martín, Miguel Ángel, Domínguez-González, Cristina“…The previously reported pathogenic homozygous mutation c.323C>T (p.Thr108Met) in TK2 was identified. This case expands the phenotypic spectrum of TK2 deficiency and indicates that it should be considered in the differential diagnosis of episodic rhabdomyolysis and exercise intolerance, along with other metabolic and mitochondrial myopathies. …”
Publicado 2021
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1066por Yang, Hong, Xiong, Feng, Qin, Hai-Bin, Yu, Qun-Tao, Sun, Jin-Yan, Zhao, Hai-Wen, Li, Dong, Zhou, Youtong, Zhang, Fu-Kun, Zhu, Xiao-Wen, Wu, Tong, Jiang, Man, Xu, Xiangmin, Lu, Youming, Shen, Hong-Jie, Zeng, Wen-Bo, Zhao, Fei, Luo, Min-Hua“…In our earlier studies, we developed H129-derived anterograde polysynaptic tracers and TK deficient (H129-dTK) monosynaptic tracers. However, their broad application is limited by some intrinsic drawbacks of the H129-dTK tracers, such as low labeling intensity due to TK deficiency and potential retrograde labeling caused by axon terminal invasion. …”
Publicado 2022
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1067“…The modified starches from TK11 had better percent recovery of the crystalline SNPs than those from TCSG2. …”
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1068por Mégarbane, Bruno, Declèves, Xavier, Bloch, Vanessa, Bardin, Christophe, Chast, François, Baud, Frédéric J“…However, further confirmatory TK/TD data are needed.…”
Publicado 2007
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1069“…The SFI-Tk consists of simple and easily understood wording and may be used to assess spine region musculoskeletal disorders in Turkish speaking patients.…”
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1070por Choi, Sung Hoon, Son, Seung Min, Lee, Dong-Ho, Lee, Choon Sung, Shin, Won Chul, Hong, Chul Gie, Lee, Jung Sub, Hwang, Chang Ju“…L1I and T1I were strongly correlated with PI/LL mismatch and PI/LL/TK mismatch, respectively. L1I and T1I are direct parameters that represent PI/LL mismatch and PI/LL/TK mismatch. …”
Publicado 2018
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1071por Murata, Kazuma, Endo, Kenji, Suzuki, Hidekazu, Matsuoka, Yuji, Takamatsu, Taichiro, Nishimura, Hirosuke, Yamamoto, Kengo“…DCS was found mostly in C3-C4 and C4-C5 (16 and 10 cases, respectively). T1S and T1-T4 TK was larger in the DCS group than in the control (T1S: 29.9 ± 2.3° vs. 23.7 ± 1.5°, T1-T4 TK: 14.9 ± 2.1° vs. 9.0 ± 1.4°). …”
Publicado 2019
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1072por Elysee, Jonathan Charles, Lovecchio, Francis, Lafage, Renaud, Ang, Bryan, Huang, Alex, Bannwarth, Mathieu, Kim, Han Jo, Schwab, Frank, Lafage, Virginie“…LL supine, TK supine, and age were significant predictors of postoperative TK (r(2) = 0.490, P < .001). …”
Publicado 2020
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1073“…The modified PcTK version was validated by performing simulations and acquiring experimental data for three different cases. …”
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1074por Tanumihardjo, Jacob P., Davis, Heidi, Zhu, Mengqi, On, Helen, Guillory, Kayla K., Christensen, Jill“…Our observational study details the structure and organizational processes (e.g., referral, services, medical and social care integration) of the Community TK at Providence Milwaukie Hospital in Portland, OR. …”
Publicado 2023
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1075por Thobe, Megan N., Gray, Jerilyn K., Gurusamy, Devikala, Paluch, Andrew M., Wagh, Purnima K., Pathrose, Peterson, Lentsch, Alex B., Waltz, Susan E.“…Moreover, TK−/− TRAMP+ prostate tumors exhibited decreased tumor vascularization relative to TK+/+ TRAMP+ prostate tumors, which correlated with reduced levels of the angiogenic molecules VEGF and CXCL2. …”
Publicado 2011
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1076por Ikegami, Shusei, Tadakuma, Takushi, Suzuki, Satoshi, Yoshimura, Ichiro, Asano, Tomohiko, Hayakawa, Masamichi“…In an in vitro gene therapy model with LNCaP cells, the cell growth inhibition in the presence of ganciclovir (GCV) was more evident in the cells transfected with the PEPM‐Cre plus CMV‐lox‐TK than in the cells with the PP‐TK, and the difference in efficacy between the two plasmids was more remarkable when the cells were maintained in CFBS medium. …”
Publicado 2002
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1077por Kulsharova, Gulsim, Dimov, Nikolay, Marques, Marco P.C., Szita, Nicolas, Baganz, Frank“…These methods were applied to immobilise transketolase (TK) in PMMA microfluidic devices. Binding efficiency studies showed that about 15% of the supplied TK was bound using the 1-step method and about 26% of the enzyme was bound by the 3-step method. …”
Publicado 2018
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1078por Zhang, Haitao, Qin, Ling, Li, Chaolu, Jiang, Jianyi, Sun, Libo, Zhao, Xiaofei, Li, Ning“…Results indicated that combined ADV-TK and GCV treatment significantly increased the number of apoptotic cells compared with the control group (P<0.05). …”
Publicado 2019
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1079por Lee, Yao, Maes, Roger K., Kruger, John M., Kiupel, Matti, Giessler, Kim S., Soboll Hussey, Gisela“…To address these shortcomings, we have constructed FeHV-1 gE-TK- and FeHV-1 PK- deletion mutants (gE-TK- and PK-) using bacterial artificial chromosome (BAC) mutagenesis and shown safety and immunogenicity in vitro. …”
Publicado 2021
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1080por Yang, Cheng, Chen, Yuhui, Huang, Hai, Fan, Shicai, Yang, Chengliang, Wang, Liping, Li, Wenqiang, Niu, Wenxin, Liao, Jianwen“…In this research, an ROS-sensitive hydrogel with strong free radical scavenging ability was prepared by introducing the thione (Tk) group into carboxymethyl chitosan (CMCTS) hydrogel. …”
Publicado 2021
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