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  1. 1141
    “…BACKGROUND: Chronic myeloid leukemia (CML) is a myeloproliferative disease caused by the constitutive tyrosine kinase (TK) activity of the BCR-ABL1 fusion protein. Accordingly, TK inhibitors have drastically changed the disease prognosis. …”
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    Hyper-activation of Aurora kinase a-polo-like kinase 1-FOXM1 axis promotes chronic myeloid leukemia resistance to tyrosine kinase inhibitors
  2. 1142
    “…Contrastingly, FdUMP was synthesized through the OPRT-RR and TP-TK pathways in LS174T cells but mainly through the TP-TK pathway in LS174T/5FUR cells. …”
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    Mechanism of acquired 5FU resistance and strategy for overcoming 5FU resistance focusing on 5FU metabolism in colon cancer cell lines
  3. 1143
    “…In this study, we constructed recombinant pseudorabies virus (rPRVXJ-delgE/gI/TK-S) expressing PDCoV spike (S) protein and evaluated its safety and immunogenicity in mice. …”
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    The recombinant pseudorabies virus expressing porcine deltacoronavirus spike protein is safe and effective for mice
  4. 1144
    “…One of these three types includes the unique sagittal profile of very small TK.…”
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    Thoracic kyphosis in light of lumbosacral alignment in thoracic adolescent idiopathic scoliosis: recognition of thoracic hypokyphosis and therapeutic implications
  5. 1145
    “…The regulation of PI‐LL was compensated through both TK and PT, with a fitting relationship of PI‐LL = 0.5 × PT − 0.2 × TK. …”
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    Sagittal Parameters of Spine‐Pelvis‐Hip Joints in Patients with Lumbar Spinal Stenosis
  6. 1146
    “…The TPA, LDI, TLK and TK increased with age in subjects who displayed type 1, whereas the PT, LL, L4–S1 and PI-LL were unchanged. …”
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    Roussouly type 2 could evolve into type 1 shape as sagittal spinal alignment deterioration progresses with age
  7. 1147
    “…AP group, p = 0.003), (LL-TK: P group vs. A group, p < 0.001, P group vs. …”
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    Physical and radiographic features of degenerative retrolisthesis in Japanese female volunteers: an observational cohort study
  8. 1148
    “…The most important of these proteins are part of the rubber transferase complex and are encoded by eight genes for cis-prenyltransferases (TkCPT), two genes for cis-prenyltransferase-like proteins (TkCPTL), one gene for rubber elongation factor (TkREF), and nine genes for small rubber particle proteins (TkSRPP). …”
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    Molecular Genetic Research and Genetic Engineering of Taraxacum kok-saghyz L.E. Rodin
  9. 1149
    “…TK-NC and TV-NC exhibited the crystallite sizes in the range of 2.55–5.94 nm as obtained by Debye Scherrer Equation and Williamsons–Hall equation The fabricated nanocomposites were characterized using FT-IR, SEM-EDX, and powder XRD. …”
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    Biochar supported metallo-inorganic nanocomposite: A green approach for decontamination of heavy metals from water
  10. 1150
    “…RESULTS: Homology-based screening revealed a gene designated pseudo-etiolated-in-light-like (TkPEL-like), and in silico analysis identified a light-responsive G-box element in its promoter. …”
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    Overexpression of a pseudo-etiolated-in-light-like protein in Taraxacum koksaghyz leads to a pale green phenotype and enables transcriptome-based network analysis of photomorphogenesis and isoprenoid biosynthesis
  11. 1151
    “…There was a brief sharp increase in TK and AAT in the first 24 hours after sham operation but no appearance of mitotic figures. …”
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    Does Liver Transplantation in the Rat Cause a Regenerative Response
  12. 1152
    “…In conclusion, the protective effects of quercetin could be due to different mechanisms resulting in NO release throughout PKC and TK intracellular signaling pathway activation.…”
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    Rat Pial Microvascular Responses to Transient Bilateral Common Carotid Artery Occlusion and Reperfusion: Quercetin’s Mechanism of Action
  13. 1153
    por DU, TONG, NIU, HONGXIN
    Publicado 2014
    “…Group 3 mice were administered splenic injections of SW480/TK-CD cells, and GCV and 5-FC were injected into the abdominal cavity. …”
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    Inhibitory effect of gene combination in a mouse model of colon cancer with liver metastasis
  14. 1154
    “…The Japanese young adults evaluated in this study tended to have a smaller PI, LLA, TK, and SVA than most Caucasian people. Regarding gender differences, SVA was significantly longer and TK was significantly smaller in men; however, there was no statistically significant difference in LLA, SS, PA, and PI. …”
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    Characteristics of Sagittal Spino-Pelvic Alignment in Japanese Young Adults
  15. 1155
    “…Treatment of TUBO tumors with Adv/CD-TK alone, however, induced neu-specific Ab responses. …”
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    Immunotherapeutic intervention with oncolytic adenovirus in mouse mammary tumors
  16. 1156
    “…Mutations in the region of the EGFR gene encoding the tyrosine kinase (TK) domain causes altered responses to EGFR TK inhibitors (TKI). …”
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    Structural investigations of T854A mutation in EGFR and identification of novel inhibitors using structure activity relationships
  17. 1157
    “…Highest levels of intracellular Mbh levels were achieved when the promoter of the entire mbh operon (TK2080-TK2093) was exchanged to a strong constitutive promoter from the glutamate dehydrogenase gene (TK1431) (strain MHG1). …”
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    Overproduction of the membrane-bound [NiFe]-hydrogenase in Thermococcus kodakarensis and its effect on hydrogen production
  18. 1158
    “…To obtain a marker-free VACV vector, we developed marker gene excision systems to modify the thymidine kinase (TK) region and N1L regions using Cre-Loxp and Flp-FRET systems respectively. …”
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    A marker-free system for highly efficient construction of vaccinia virus vectors using CRISPR Cas9
  19. 1159
    por Merrick, Catherine J.
    Publicado 2015
    “…RESULTS: Introduction of a TK gene produces parasites that can indeed incorporate BrdU. …”
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    Transfection with thymidine kinase permits bromodeoxyuridine labelling of DNA replication in the human malaria parasite Plasmodium falciparum
  20. 1160
    “…Although overexpression or constitutive activation of tyrosine kinases (TKs) through gene amplification, translocation or mutation are well-characterized oncogenic events, current knowledge about translational mechanisms of TK activation is scarce. Here, we report the presence of translational cis-regulatory upstream open reading frames (uORFs) in the majority of transcript leader sequences of human TK mRNAs. …”
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    Comprehensive translational control of tyrosine kinase expression by upstream open reading frames
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