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  1. 1161
    “…Expressing double-stranded RNA (dsRNA) in transgenic plants to silence essential genes within herbivorous pests is referred to as trans-kingdom RNA interference (TK-RNAi) and has emerged as a promising strategy for crop protection. …”
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    In-Plant Protection against Helicoverpa armigera by Production of Long hpRNA in Chloroplasts
  2. 1162
    “…METHODS: In the present study, an antigen delivery platform based on a recombinant bovine herpesvirus 4 (BoHV-4), delivering a synthetic EBOV glycoprotein (GP) gene sequence, BoHV-4-syEBOVgD106ΔTK, was generated. RESULTS: EBOV GP was abundantly expressed by BoHV-4-syEBOVgD106ΔTK transduced cells without decreasing viral replication. …”
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    BoHV-4-based vector delivering Ebola virus surface glycoprotein
  3. 1163
    “…Taraxacum kok-saghyz (TK) is a potential alternative crop for natural rubber (NR) production, due to its high molecular weight rubber, short breeding cycle, and diverse environmental adaptation. …”
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    Analysis of the first Taraxacum kok-saghyz transcriptome reveals potential rubber yield related SNPs
  4. 1164
    “…We generate Rosa26-mT/sr39tk PET reporter mice and induce sr39tk expression in platelets, T lymphocytes or cardiomyocytes. …”
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    Cre/lox-assisted non-invasive in vivo tracking of specific cell populations by positron emission tomography
  5. 1165
    por Zweiri, Jehad, Christmas, Stephen E.
    Publicado 2017
    “…In contrast, TK-modified human and mouse mesothelioma cells were found to retain their in vitro and in vivo bystander killing effect after γ-irradiation. …”
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    The impact of γ-irradiation on the induction of bystander killing by genetically engineered ovarian tumor cells: implications for clinical use
  6. 1166
    “…The viability of Huh7 cells was not reduced in the presence of GCV after infection by Ad-tk-122a vector. In contrast, cytotoxicity of HSV-tk/GCV was similar in Huh7 cells and HepG2 cells by Ad-tk vector, with 35.3% and 27% viability, respectively. …”
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    Regulation of HSVtk gene by endogenous microRNA-122a in liver cell lines as suicide gene therapy
  7. 1167
    por Nishida, Satoshi, Ono, Yasuo
    Publicado 2018
    “…CONCLUSION: Differences in pathogenicity among carbapenem-resistant A. baumannii clones are consistent with heterogeneous clinical outcomes. Strain TK1033, isolated frequently during the outbreak, was the most virulent, whereas preoutbreak isolate TK1032 was less virulent than other A. baumannii isolates. …”
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    Comparative analysis of the pathogenicity between multidrug-resistant Acinetobacter baumannii clinical isolates: isolation of highly pathogenic multidrug-resistant A. baumannii and experimental therapeutics with fourth-generation cephalosporin cefozopran
  8. 1168
    “…Preoperatively, the mean TK and LL were 36.8° and 55.3°. At the last follow up, the mean TK and LL were 27.1° and 49.0° degrees, respectively. …”
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    Analysing the change of sagittal balance in patients with Lenke 5 idiopathic scoliosis
  9. 1169
    por Zhen, Gao, Yingying, Liu, Jingcheng, Dong
    Publicado 2018
    “…The objective of this systematic review is to evaluate the efficacy and safety of tonifying kidney therapy (Bushen, TK) for stable COPD. METHODS: Randomized controlled trials (RCTs) of TK for stable COPD were searched from 4 databases including Pubmed, the Cochrane library, CBM (China Biology Medicine disc, CBMdisc), CNKI (China National Knowledge Infrastructure) from inception to December 2017. …”
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    Traditional Chinese medicine tonifying kidney therapy (Bu shen) for stable chronic obstructive pulmonary disease: Protocol for a systematic review and meta-analysis
  10. 1170
    “…PURPOSE: The arterial input function (AIF) is a major source of uncertainty in tracer kinetic (TK) analysis of dynamic contrast‐enhanced (DCE)‐MRI data. …”
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    Improved repeatability of dynamic contrast‐enhanced MRI using the complex MRI signal to derive arterial input functions: a test‐retest study in prostate cancer patients
  11. 1171
    “…Subsequently, the NTP showed that a variety of BCEs, including the sample that induced micronuclei (MN) in vivo (“NTP BCE”) had a similar effect in human TK6 cells. Further testing with the MultiFlow® DNA Damage Assay revealed that TK6 cells exposed to NTP BCE, as well as a BCE reference material (BC XRM), exhibited a signature consistent with aneugenic activity in TK6 cells. …”
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    Evidence for an Aneugenic Mechanism of Action for Micronucleus Induction by Black Cohosh Extract
  12. 1172
    “…OBJECTIVE: This study aimed to appraise the efficacy and safety of the tonifying-Shen (kidney) principle (TS (TK) principle) for primary osteoporosis (POP). METHODS: Randomized controlled clinical trials (RCTs) using the TS (TK) principle for POP were searched from eight electronic databases to search for relevant literature that was published from the initiation to September 2019. …”
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    The Efficacy and Safety of Traditional Chinese Medicine Tonifying-Shen (Kidney) Principle for Primary Osteoporosis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
  13. 1173
    “…We propose that radiographs obtained when patients are in supine position are valuable for evaluating the flexibility of the TK. Rigid TK might be an etiology of restrictive ventilatory impairment in patients with ASD.…”
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    Prevalence and Key Radiographic Spinal Malalignment Parameters Associated with the Risk of Pulmonary Function Impairment in Patients Treated Surgically to Correct Adult Spinal Deformity
  14. 1174
    “…This phase I dose-escalation pilot trial assessed bronchoscopic delivery of AdV-tk in patients with suspected lung cancer who were candidates for surgery. …”
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    Neoadjuvant Gene-Mediated Cytotoxic Immunotherapy for Non-Small-Cell Lung Cancer: Safety and Immunologic Activity
  15. 1175
    “…SIMPLE SUMMARY: TAM receptors are a family of receptor tyrosine kinases, comprising Tyro3, Axl and MerTK. Their primary role is in digestion of dying cells by macrophages without alarming the immune system. …”
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    TAM Receptor Inhibition–Implications for Cancer and the Immune System
  16. 1176
    “…Hypothetical values of LL and TK, and positive or negative-sum of (LL + TK), are weak predictors for occurrences of PJK.…”
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    Proximal Junction Kyphosis in Adult Scoliosis: Best Postoperative Radiological Predictors—A Retrospective Cohort Study
  17. 1177
    “…The subjects were evaluated by two independent assessors using FC and SPI to measure the TK angle. The intraclass correlation coefficient (ICC) was analysed at a 95% confidence interval. …”
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    Reliability of the Smartphone Application Inclinometer and Flexicurve in Measuring Thoracic Kyphosis
  18. 1178
    “…We generated transgenic mice that express herpes simplex virus thymidine kinase under control of the DCX promoter (DCX-TK transgenic mice). DCX-expressing and recently divided cells in the rostral subventricular zone (SVZ) and hippocampus of DCX-TK transgenic mice, but not wild-type mice, were specifically depleted after ganciclovir (GCV) treatment for 14 days. …”
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    Conditional Depletion of Neurogenesis Inhibits Long-Term Recovery after Experimental Stroke in Mice
  19. 1179
    “…We also found compensatory increases in cytosolic deoxycytidine kinase (dCK) and thymidine kinase 1 (TK1) and in mitochondrial deoxyguanosine kinase (dGK), all of the salvage dNTP supply system; in contrast, the remaining mitochondrial salvage enzyme thymidine kinase 2 (TK2) decreased with p53 loss. …”
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    dNTP Supply Gene Expression Patterns after P53 Loss
  20. 1180
    “…In the present work, a rabbit PBPK/TK model is developed and evaluated with data available from the literature. …”
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    Development and validation of a physiology-based model for the prediction of pharmacokinetics/toxicokinetics in rabbits
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