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  1. 1201
    “…RESULTS: The intranasal administration of BoHV-4-A-S-ΔRS-HA-ΔTK elicited protection against SARS-CoV-2, with improved clinical signs, including significant reductions in body weight loss, significant reductions in viral load in the trachea and lungs, and significant reductions in histopathologic lung lesions compared to BoHV-4-A-S-ΔRS-HA-ΔTK administered intramuscularly. …”
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    Assessment of BoHV-4-based vector vaccine intranasally administered in a hamster challenge model of lung disease
  2. 1202
    “…Multilinear regression predicting L1-S1 based on TK, TPA, and PI demonstrated excellent results (R2 = .85). …”
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    How Much Lumbar Lordosis does a Patient Need to Reach their Age-Adjusted Alignment Target? A Formulated Approach Predicting Successful Surgical Outcomes
  3. 1203
    “…Targeting these abnormalities by blocking TK of BCR-ABL with STI571 provided a promising approach for the therapy of CML. …”
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    Tyrosine kinase inhibitor AG1024 exerts antileukaemic effects on STI571-resistant Bcr-Abl expressing cells and decreases AKT phosphorylation
  4. 1204
    “…Furthermore, this HSV1-tk-expressing CSC-like population was sensitive to ganciclovir applied for the suicide therapy. …”
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    Remnant living cells that escape cell loss in late-stage tumors exhibit cancer stem cell-like characteristics
  5. 1205
    “…Quantitative relationships between PET, thymidine kinase 1 (TK1) protein levels and immunostaining for proliferation markers (Ki67, TK1, PCNA) were evaluated using imaging-matched tumor specimens. …”
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    Limits of [(18)F]-FLT PET as a Biomarker of Proliferation in Oncology
  6. 1206
    “…In previous studies, we constructed a pulmonary surfactant-associated protein A (SPA) suicide gene system, rAAV-SPA-TK, which induced apoptosis in alveolar epithelial type II (AT II) cells and vacated the AT II cell niche. …”
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    Regulation of transplanted mesenchymal stem cells by the lung progenitor niche in rats with chronic obstructive pulmonary disease
  7. 1207
    “…Pretreatment DCE-MRI data on advanced HCC were analyzed using five different WX kinetic models: the Tofts-Kety (WX-TK), extended TK (WX-ETK), two compartment exchange, adiabatic approximation to tissue homogeneity (WX-AATH), and distributed parameter (WX-DP) models. …”
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    Water-Exchange-Modified Kinetic Parameters from Dynamic Contrast-Enhanced MRI as Prognostic Biomarkers of Survival in Advanced Hepatocellular Carcinoma Treated with Antiangiogenic Monotherapy
  8. 1208
    “…Local farmers have developed ancient breeding programs entrenched in traditional knowledge (TK) that has sustained rural cultures for thousands of years. …”
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    DNA record of some traditional small millet landraces in India and Nepal
  9. 1209
    “…To constitute the site‐specific expression of the herpes simplex virus thymidine‐kinase (HSV‐TK) gene in tumor cells, we have assessed the promoter function of the simian virus 40 (SV40) promoter and the 5’flanking region of c‐erbB‐2 gene using a luciferase‐expressing reporter plasmid. …”
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    Direct Intratumoral Gene Transfer of the Herpes Simplex Virus Thymidine Kinase Gene with DNA‐liposome Complexes: Growth Inhibition of Tumors and Lack of Localization in Normal Tissues
  10. 1210
    “…However, only DTI-TK revealed radial diffusivity (RD) to be driving this FA correlation with disease duration. …”
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    Influence of analytic techniques on comparing DTI-derived measurements in early stage Parkinson's disease
  11. 1211
    “…After the knockdown of TK, the FdUMP after treatment with FdU was decreased in MKN45 cells. …”
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    The inhibition of thymidine phosphorylase can reverse acquired 5FU-resistance in gastric cancer cells
  12. 1212
    “…Major components of the total oligosaccharides were high-mannose type N-glycans, whose level increased in MTX-resistant HKBML and TK but decreased in MTX-resistant RAJI. We also detected sialylated biantennary galactosylated N-glycans with α1,6-fucosylation, A2G2F, and A2G2FB from HKBML, TK, and RAJI. …”
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    Differential expression of N-linked oligosaccharides in methotrexate-resistant primary central nervous system lymphoma cells
  13. 1213
    “…First, we found that neurogenesis was disrupted in male and female mice chronically deficient for two phagocytosis pathways: the purinergic receptor P2Y12, and the tyrosine kinases of the TAM family Mer tyrosine kinase (MerTK)/Axl. In contrast, neurogenesis was transiently increased in mice in which MerTK expression was conditionally downregulated. …”
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    Microglia Actively Remodel Adult Hippocampal Neurogenesis through the Phagocytosis Secretome
  14. 1214
    “…Compounds trans-13c, cis-13c/trans-13c (86:14), cis-15b/trans-15b (87:13) and trans-15d/cis-15d (95:5) exhibited the highest activity toward both TK(+) and TK(−) VZV strains (mean EC(50) values in the range of 3.0–8.7 μM). …”
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    Synthesis, anti-varicella-zoster virus and anti-cytomegalovirus activity of quinazoline-2,4-diones containing isoxazolidine and phosphonate substructures
  15. 1215
    “…METHODS: Herpes simplex virus 1-thymidine kinase (HSV1-TK) and 9-(4-[(18)F]fluoro-3-(hydroxymethyl)butyl)guanine ((18)F-FHBG) were used as a pair of reporter gene/reporter probe for positron emission tomography (PET) imaging in this study. …”
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    (18)F-FHBG PET-CT Reporter Gene Imaging of Adoptive CIK Cell Transfer Immunotherapy for Breast Cancer in a Mouse Model
  16. 1216
    “…A sufficient quantitative understanding of aluminium (Al) toxicokinetics (TK) in man is still lacking, although highly desirable for risk assessment of Al exposure. …”
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    Physiology-based toxicokinetic modelling of aluminium in rat and man
  17. 1217
    “…OBJECTIVES: The objective of the study was to illustrate how toxicokinetic (TK) study design and data analysis can be implemented under the 4R rule to plan a chronic dosage regimen for investigating TK/toxicodynamic (TD) relationships. …”
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    Use of Mixture Dosing and Nonlinear Mixed Effect Modeling of Eight Environmental Contaminants in Rabbits to Improve Extrapolation Value of Toxicokinetic Data
  18. 1218
    “…RESULTS: There was a significant increase in thoracic kyphosis (TK) from T1–T12 and T4–T12 with increasing age. …”
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    Radiographic Analysis of the Sagittal Alignment of Spine and Pelvis in Asymptomatic Indian Population
  19. 1219
    “…Combating acquired drug resistance of EGFR tyrosine kinase (TK) is a great challenge and an urgent necessity in the management of non-small cell lung cancers. …”
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    Quinoxalinones as A Novel Inhibitor Scaffold for EGFR (L858R/T790M/C797S) Tyrosine Kinase: Molecular Docking, Biological Evaluations, and Computational Insights
  20. 1220
    “…We found a significant correlation between Δthoracic kyphosis (TK) and Δcervical lordosis. Preoperative cervical kyphosis, ΔT1 slope, and ΔTK were independently associated factors for postoperative cervical hyperkyphosis. …”
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    Reciprocal Change of Cervical Spine after Posterior Spinal Fusion for Lenke Type 1 and 2 Adolescent Idiopathic Scoliosis
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