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121por Belkhelfa, Sophia, Roche, David, Dubois, Ivan, Berger, Anne, Delmas, Valérie A., Cattolico, Laurence, Perret, Alain, Labadie, Karine, Perdereau, Aude C., Darii, Ekaterina, Pateau, Emilie, de Berardinis, Véronique, Salanoubat, Marcel, Bouzon, Madeleine, Döring, Volker“…Turbidostat and conditional medium swap regimes were employed for the parallel evolution of the recently characterized strain TK 0001 and the reference strain AM1 and enabled the isolation of derivatives of both strains capable of stable growth with 10% methanol. …”
Publicado 2019
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122“…RESULTS: We have identified four acting thiol-disulphide oxidoreductases (TDORs) in S. lividans TK21, mutants in all TDOR candidates affect the secretion and activity of the Sec-dependent alpha-amylase, which contains several disulphide bonds, but the effect was more drastic in the case of the Sli-DsbA deficient strain. …”
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123por Novitskiy, Sergey V., Zaynagetdinov, Rinat, Vasiukov, Georgii, Gutor, Sergey, Han, Wei, Serezani, Ana, Matafonov, Anton, Gleaves, Linda A., Sherrill, Taylor P., Polosukhin, Vasiliy V., Blackwell, Timothy S.“…To assess the therapeutic potential for combination treatment targeting NF-κB and Gas6-MerTK, we injected Lewis Lung Carcinoma cells subcutaneously and treated mice with Bay 11-70852 (NF-κB inhibitor) and/or Foretinib (MerTK inhibitor). …”
Publicado 2019
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124por Kenmochi, Hiroaki, Yamasaki, Tomohiro, Oishi, Tomoya, Horikawa, Makoto, Yamamoto, Taisuke, Koizumi, Shinichiro, Sameshima, Tetsuro, Namba, Hiroki“…BACKGROUND: Herpes simplex virus-thymidine kinase/ganciclovir (HSV-tk/GCV) system is one of feasible therapeutic strategies for defeating malignant gliomas. …”
Publicado 2019
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125por Dominguez-Gonzalez, Cristina, Badosa, Carmen, Madruga-Garrido, Marcos, Martí, Itxaso, Paradas, Carmen, Ortez, Carlos, Diaz-Manera, Jordi, Berardo, Andres, Alonso-Pérez, Jorge, Trifunov, Selena, Cuadras, Daniel, Kalko, Susana G., Blázquez-Bermejo, Cora, Cámara, Yolanda, Martí, Ramon, Mavillard, Fabiola, Martin, Miguel A., Montoya, Julio, Ruiz-Pesini, Eduardo, Villarroya, Joan, Montero, Raquel, Villarroya, Francesc, Artuch, Rafael, Hirano, Michio, Nascimento, Andrés, Jimenez-Mallebrera, Cecilia“…We investigated the application of GDF-15 as biomarker of disease severity and response to deoxynucleoside treatment in patients with thymidine kinase 2 (TK2) deficiency and compared it to FGF-21. GDF-15 and FGF-21 were measured in serum from 24 patients with TK2 deficiency treated 1–49 months with oral deoxynucleosides. …”
Publicado 2020
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126por Ibrahim, Mahmoud Abdelghany, Yasui, Manabu, Saha, Liton Kumar, Sasanuma, Hiroyuki, Honma, Masamitsu, Takeda, Shunichi“…The OECD guidelines define the bioassays of identifying mutagenic chemicals, including the thymidine kinase (TK) assay, which specifically detects the mutations that inactivate the TK gene in the human TK6 lymphoid line. …”
Publicado 2020
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127por Papadimas, George K., Vargiami, Efthimia, Dragoumi, Pinelopi, Van Coster, Rudy, Smet, Joel, Seneca, Sara, Papadopoulos, Constantinos, Kararizou, Evangelia, Zafeiriou, Dimitrios“…Few severely affected cases carrying the c.416C > T mutation in TK2 gene have been described so far. We describe the case of a 14months boy with the aforementioned TK2 gene pathogenic mutation at a homozygous state, presenting with a mild clinical phenotype. …”
Publicado 2020
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128“…For this reason, we thought useful to continue the research, by investigating the potential antimutagenic activity of 6-MITC and thus better define its profile as a possible chemopreventive agent. 6-MITC antimutagenic effect against two known mutagenic agents: the clastogen Mitomycin C (MMC) and the aneuplodogen Vinblastine (VINB), was analyzed, in terms of micronuclei frequency decrease, after short- and long- time treatment on TK6 human cells, using a new automated protocol of the “In Vitro Mammalian Cell Micronucleous Test” by flow cytometry. …”
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129Isolation and Characterization of a Variant Psedorabies Virus HNXY and Construction of rHNXY-∆TK/∆gEpor Wu, Fengsun, Lv, Yujin, Zhang, Shijun, Liu, Lingling, Wu, Yuchen, Zhao, Pandeng, Peng, Zhifeng, Liu, Shengli, Zhang, Zhonghua, Li, Wengang“…The attenuated rHNXY-∆TK/∆gE was further constructed, which presented significantly smaller plaques than HNXY, as well as the similar growth kinetics. rHNXY-∆TK/∆gE was confirmed to be non-pathogenic to six-week-old BALB/c mice and zero-day-old piglets. …”
Publicado 2020
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130“…It is a process involved with two steps whereby the gene (HSV-tk) is first delivered to malignant cells. Afterward, non-toxic GCV is administered to that site and activated to cytotoxic ganciclovir triphosphate by HSV-tk enzyme expressed exogenously. …”
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131por Droste, Julian, Rückert, Christian, Kalinowski, Jörn, Hamed, Mohamed Belal, Anné, Jozef, Simoens, Kenneth, Bernaerts, Kristel, Economou, Anastassios, Busche, Tobias“…Streptomyces lividans TK24 is a relevant Gram-positive soil inhabiting bacterium and one of the model organisms of the genus Streptomyces. …”
Publicado 2021
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132por Li, Yong, Sun, Tiehu, Hong, Yuxuan, Qiao, Tong, Wang, Yongsheng, Li, Wei, Tang, Shi, Yang, Xin, Li, Jie, Li, Xiaowen, Zhou, Zutao, Xiao, Yuncai“…To explore the feasibility of using fermented Chinese herbal mixture Zhihuasi Tk (Z. Tk) supplementation to increase the swine production, the protective effect of dietary supplementation with Z. …”
Publicado 2021
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133por Özdemir, Ahmet, Ciftci, Halilibrahim, Sever, Belgin, Tateishi, Hiroshi, Otsuka, Masami, Fujita, Mikako, Altıntop, Mehlika Dilek“…This compound also inhibited EGFR TK with an IC(50) value of 17.58 µM compared to erlotinib (IC(50) = 0.04 µM) and induced apoptosis (56.30%). …”
Publicado 2022
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134Macrophage MerTK promotes profibrogenic cross-talk with hepatic stellate cells via soluble mediatorspor Pastore, Mirella, Caligiuri, Alessandra, Raggi, Chiara, Navari, Nadia, Piombanti, Benedetta, Di Maira, Giovanni, Rovida, Elisabetta, Piccinni, Marie-Pierre, Lombardelli, Letizia, Logiodice, Federica, Rombouts, Krista, Petta, Salvatore, Marra, Fabio“…METHODS: Macrophages were derived from THP-1 cells or differentiated from peripheral blood monocytes towards MerTK(+)/CD206(+)/CD163(+)/CD209(-) macrophages. The role of MerTK was assessed by pharmacologic and genetic inhibition. …”
Publicado 2022
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135por Rousseau, Antoine, Haigh, Oscar, Legrand, Roger, Palgen, Jean-Louis, Lemaitre, Julien, Deback, Claire, Oziol, Noémie, Lomonte, Patrick, Labetoulle, Marc“…We previously engendered an acute disease-free, non-reactivating latent state in mice when challenged with virulent HSV-1 in orofacial mucosa, by priming with non-neurovirulent HSV-1 (TK(del)) before the challenge. Herein, we define the local immune infiltration and inflammatory chemokine production changes after virulent HSV-1 challenge, which were elicited by TK(del) prime. …”
Publicado 2022
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136por Qiu, Haori, Yang, Bincai, Chen, Yuhai, Zhu, Qianwen, Wen, Faxin, Peng, Min, Wang, Guoqing, Guo, Guijie, Chen, Biao, Maarouf, Mohamed, Fang, Min, Chen, Ji-Long“…Poly(I:C) and interferon β (IFN-β) stimulated circMerTK expression, while RIG-I knockout and IFNAR1 knockout cell lines failed to elevate circMerTK levels after IAV infection, demonstrating that circMerTK is regulated by IFN signaling. …”
Publicado 2023
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137por Tang, Aoxing, Zhu, Meng, Zhu, Jie, Zhang, Da, Zhu, Shiqiang, Wang, Xiao, Meng, Chunchun, Li, Chuangfeng, Liu, Guangqing“…METHODS: To address these shortcomings, we constructed FHV ∆gIgE-eGFP, FHV ∆TK mCherry, and FHV ∆gIgE/TK eGFP-mCherry deletion mutants (ΔgI/gE, ΔTK, and ΔgIgE/TK, respectively) using the clustered regularly interspaced palindromic repeats (CRISPR)/CRISP-associated protein 9 (Cas9) system (CRISPR/Cas9), which showed safety and immunogenicity in vitro. …”
Publicado 2023
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138“…Previous studies have found that Bifidobacterium infantis-mediated herpes simplex virus-TK/ganciclovir (BF-TK/GCV) reduces the expression of VEGF and CD146, implying tumor metastasis inhibition. …”
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139“…In addition, TK216 sharply decreased Mcl-1 protein levels in a dose-dependent manner. …”
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140“…Therefore, novel EKB-569 in combination with sorafenib may be able to overcome HCC resistance to EGFR-TK inhibitors.…”
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