“…We present the selection of two improved variants of ToTK1 generated by random protein engineering for suicide gene therapy with the NA azidothymidine (AZT). …”
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“…Zucker Diabetic Fatty (ZDF) rat, a common model for type 2 diabetes mellitus (T2DM), had high levels of d-ribose and HbA1c, accompanied by a decrease of transketolase (TK) in the liver. The administration of benfotiamine, an activator of TK, significantly decreased d-ribose followed by a decline in HbA1c. …”
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“…A series of 2-arylbenzo[c]furan-chalcone hybrids 3a–y have been synthesized and evaluated for antiproliferative effects against the human breast cancer (MCF-7) cell line and for its potential to induce apoptosis and also to inhibit tubulin polymerization and/or epidermal growth factor receptor-tyrosine kinase (EGFR-TK) phosphorylation. Most of these compounds exhibited moderate to significant antigrowth effects in vitro against the MCF-7 cell line when compared to the reference standard actinomycin D. …”
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“…Compound 16b exhibited the highest activity against a thymidine kinase-deficient (TK(−)) VZV strain (EC(50) = 27.59 μM), while 16d was the most potent towards TK(+) VZV (EC(50) = 29.91 μM). …”
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“…Transketolase (TK) catalyzes a reversible transfer of a two‐carbon (C(2)) unit between phosphoketose donors and phosphoaldose acceptors, for which the group‐transfer reaction that follows a one‐ or two‐electron mechanism and the force that breaks the C2“−C3” bond of the ketose donors remain unresolved. …”
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“…One compound was slightly active against human cytomegalovirus in HEL cell cultures (EC(50) = 45 μM) while another showed weak activity against varicella-zoster virus (TK(+) VZV strain OKA and TK(−) VZV strain 07-1) with EC(50) = 43 and 53 µM, respectively. …”
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“…The European Food Safety Authority (EFSA) tiered approach for food additives in concordance with the safety assessment of chemicals in food developed by Food and Agriculture Organization/World Health Organization (FAO/WHO) was followed; the miniaturized Ames test in Salmonella typhimurium TA97a, TA98, TA100, TA102, and TA1535 strains (following the principles of Organization for Economic Co-operation and Development (OECD) 471), and the micronucleus test (OECD 487) in TK6 cells were performed. In addition, the in vitro standard and enzyme-modified (human 8-oxoguanine DNA glycosylase 1 (hOGG), endonuclease III (EndoIII), human alkyladenine DNA glycosylase (hAAG)) comet assay (S9−/S9+) was conducted in order to assess the potential premutagenic lesions in TK6 cells. …”
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“…We therefore investigated the self-pollination and cross-pollination of two compatible T. koksaghyz varieties (TkMS2 and TkMS3) by microscopy and transcriptomic analysis to shed light on the pollination process. …”
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“…Polymerase chain reaction (PCR) amplification of the thymidine kinase gene (TK) was successful in 16/140 (11.4%) of the suspected cases. …”
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“…Intergroup comparisons were performed to identify statistical significance in terms of the following parameters: serum NGF, TK1, and CA15-3 levels; VAS, SAS, and SDS scores; nursing compliance; incidence of adverse reactions; and nursing satisfaction. …”
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“…The MTT results are in accordance with the binding affinities found by docking the said molecules with HER2 Tyrosine Kinase (HER2-TK). Compound 3b is identified as a promising HER2-TK inhibitor and also shows effective inhibition against Gram-positive bacteria Staphylococcus aureus.…”
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“…Notably, as in the case of ALK, STAT proteins have emerged as key downstream factors for most of the involved TK.…”
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“…Uncertainties exist about their comparative mammalian toxicokinetic (‘TK’) profiles, including their relative oral route bioavailability, especially for Ag massive and powder forms. …”
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“…CONCLUSION: Quizartinib is a potent second-generation class III receptor TK-inhibitor – but specific, mutation restricted spectrum of activity may require mutation screening prior to therapy.…”
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“…Cerebellar granule cell (CGC) apoptosis by trophic/potassium (TK) deprivation is a model of election to study the interplay of pro-apoptotic and pro-survival signaling pathways in neuronal cell death. …”
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“…We also utilized the anti-selection gene HSV-TK, which results in cell death in strains grown on the drug 5-Fluoro-2’-deoxyuridine (FdU, Floxuridin or FUDR). …”
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“…The following parameters were recorded: C7 SVA, C2-C7 CL, TK, LL, TPA, T1SPi, PI, PT, SS, L4-S1 angle, L1-L4 angle, PI-LL mismatch and CTPA. …”
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“…While mice carrying the suicide gene thymidine kinase (TK) along with the GFP reporter, under the control of the Nestin promoter regions (Nestin(TK) mice) were used to label and selectively kill SC-NSCs. …”
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“…We disrupted the PDIP38 gene, generating PDIP38(-/-) cells from the chicken DT40 and human TK6 B cell lines. These PDIP38(-/-) cells did not show a significant sensitivity to either UV or H(2)O(2), a phenotype not seen in any TLS-polymerase-deficient DT40 or TK6 mutants. …”
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“…BACKGROUND: Traditional knowledge (TK) on the different uses of under-valued fruit tree species including Gardenia erubescens Stapf & Hutch.…”
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