“…Of notice, both AduPARTK(T) and ICOVIR15-TK(T) antitumoral responses were stronger by ductal viral application than intravenously, in line with the 38-fold increase in pancreas transduction observed upon ductal administration. …”
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“…Thus, an increased FLT uptake level was demonstrated following the treatment, which may indicate the suppression of thymidylate synthase (TS) and the compensatory upregulation of TK-1 activity by sorafenib.…”
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“…The first approved TK inhibitor (TKI) was Imatinib Mesylate (Glivec or Gleevec, Novartis). …”
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“…Nine morphological parameters including nuclear size, perinuclear halo, hyperchromasia, typical koilocyte (TK), abortive koilocyte (AK), bi-/multi-nucleation, keratohyaline granules, inflammation, and dyskeratosis were examined for each case. …”
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“…Genotoxicity profiles of ZnO > Ag > Fe(2)O(3) > CeO(2) > SiO(2) in TK6 cells at 4 h and Ag > Fe(2)O(3) > ZnO > CeO(2) > SiO(2) in H9T3 cells at 24 h were observed. …”
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“…Previously, we developed a transgenic strain of L. major that harbors two suicide genes tk and cd genes (lmtkcd(+/+)) for use as a challenge strain in vaccine studies. …”
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“…We developed a combined conditional cytotoxic, i.e., herpes simplex type 1-thymidine kinase (TK), plus immune-stimulatory, i.e., fms-like tyrosine kinase ligand-3–mediated gene therapy for glioblastoma multiforme (GBM). …”
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“…In this study, we show that epithelial (BEAS-2B), fibroblast (HFF-1), and lymphoblastoid (TK6) cells show different biological responses following exposure to QDs. …”
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“…In this study, we explored the applicability of using in vitro micronucleus (MN) data from human lymphoblastoid TK6 cells to derive in vivo genotoxicity potency information. …”
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“…In the present study, gene recombination technology was used to construct two types of gene expression vectors that contained the P1 promoter of the CD133 gene, which regulated either the neomycin-resistance gene or the herpes simplex virus thymidine kinase (HSV-TK) gene. Following the stable transfection of U251 glioblastoma cells with these two gene vectors, the cells expressing the P1 promoter that regulated the neomycin-resistance gene were named CD133 (+) cells, while the cells expressing the P1 promoter regulating the HSV-TK gene were called CD133 (−) cells. …”
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“…CONCLUSION: All experimental results indicated that DTI-TK performed the best under the study conditions, and SyN ranked just behind it.…”
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“…CBY1 reduced expression in clonal progenitors and, more importantly, in leukemic stem cells (LSC), is contingent upon the tyrosine kinase (TK) activity of BCR-ABL1 fusion protein. Accordingly, its induction by Imatinib (IM) and second generation TK inhibitors contributes to β-catenin inactivation through multiple events encompassing the activation of endoplasmic reticulum (ER) stress-associated unfolded protein response (UPR) and autophagy, eventually leading to apoptotic death. …”
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“…Pazopanib, a multitarget tyrosine kinase (TK) inhibitor, has been approved for treatment of soft tissue sarcoma. …”
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“…The dual reconstituted TK-NOG mouse model is a feasible platform to investigate hepatocyte-related HIV-1 immunopathogenesis. …”
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“…However, during push-up plus, thoracic kyphosis (TK) may usually occur as a compensatory movement. …”
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“…Serum antibodies specific for EBNA1, Zta, Thymidine Kinase (TK), EAD, EAR, and VCA were detected by enzyme‐linked immunosorbent assay. …”
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“…The activity of thymidine kinase (TK) and the uptake ratio of 5‐hromo‐2′‐deoxyuridine (BrdU), indices of salvage pathway activity, were significantly lower in the AZT and 5‐FU plus AZT groups than in the control group (TK, P<0.05, P< 0.01; uptake ratio of BrdU, P< 0.01, P< 0.05, respectively). …”
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“…RESULTS: HAI of high doses of VV(tk−) did not cause any acute or chronic changes in body weight, survival or in biochemical, hematological tests in the 2 animal models, and none of the changes showed dose dependency (in rabbit study), or were influenced by liver cirrhosis (in rat study). …”
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“…In a human EJ bladder cancer xenograft mouse model, with either overexpressed or suppressed CD46 expression levels, Ad5/35-tk followed by ganciclovir (GCV) treatment significantly affected tumor growth, whereas Ad5-tk/GCV had only minimal effects. …”
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“…The delivery of the HSV-tk gene by Metafectene or GeneJammer in the presence of 0% or 60% FBS, followed by GCV treatment for 6 days, resulted in over 90% cytotoxicity. …”
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