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1741por Badura, Susanne, Tesanovic, Tamara, Pfeifer, Heike, Wystub, Sylvia, Nijmeijer, Bart A., Liebermann, Marcus, Falkenburg, J. H. Frederik, Ruthardt, Martin, Ottmann, Oliver G.“…In Philadelphia chromosome (Ph) positive leukemias, activation of PI3K by dysregulated BCR-ABL tyrosine kinase (TK) contributes to the pathogenesis and development of resistance to ABL-TK inhibitors (TKI). …”
Publicado 2013
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1742por Zizzo, Gaetano, Guerrieri, Justus, Dittman, Lindsay M, Merrill, Joan T, Cohen, Philip L“…Membrane expression of MerTK, AXL and CD163 was assessed by flow cytometry. …”
Publicado 2013
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1743por Kern, Georg, Mair, Sabine M., Noppert, Susie-Jane, Jennings, Paul, Schramek, Herbert, Rudnicki, Michael, Mueller, Gerhard A., Mayer, Gert, Koppelstaetter, Christian“…In the human renal fibroblast cell line TK-173, the macrolide calcineurin inhibitor tacrolimus (FK-506) induced TGF-β-like effects, manifested by increased expression of NAD(P)H-oxidase 4 (Nox4), transgelin, tropomyosin 1, and procollagen α1(V) mRNA after three days. …”
Publicado 2014
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1744por Shi, Benlong, Mao, Saihu, Xu, Leilei, Sun, Xu, Liu, Zhen, Zhu, Zezhang, Lam, Tsz Ping, Cheng, Jack CY, Ng, Bobby, Qiu, Yong“…The multivariate regression analysis revealed the following pre-operative variables contributed significantly to ΔSH: pre-op Cobb angle, pre-op TK (single curve group only), pre-op GK (double curve group only) and pre-op LL (double curve group only) (p < 0.05). …”
Publicado 2016
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1745“…After fermentation for 2 days, S. lividans TK24 that harbored pIJ86/tg1 produced 1.8 U/mL of TGase, and a clear TGase band (38 kDa) was detected in the culture supernatant. …”
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1746por Bertran, Kateri, Lee, Dong-Hun, Balzli, Charles, Pantin-Jackwood, Mary J., Spackman, Erica, Swayne, David E.“…To assess any potential genetic resistance of broilers and/or age-related effects, we investigated the pathogenesis and transmission of A/turkey/Minnesota/12582/2015 (H5N2) (Tk/MN/15) virus in commercial 5-week-old broilers, 8-week-old broilers, and >30-week-old broiler breeders. …”
Publicado 2016
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1747por Srivastava, Jitendra Kumar, Pillai, Girinath G., Bhat, Hans Raj, Verma, Amita, Singh, Udaya Pratap“…These molecules showed considerable inhibitory percentage against Epidermal Growth Factor Receptor tyrosine kinase (EGFR-TK), in in-vitro assay. Molecular docking study was carried out on the analogs and reference compound (Erlotinib) into the ATP binding site of EGFR-TK domain (PDB ID:1M17) to elucidate vital structural residues necessary for bioactivity. …”
Publicado 2017
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1748por Merrill, Robert K., Kim, Jun S., Leven, Dante M., Meaike, Joshua J., Kim, Joung Heon, Cho, Samuel K.“…A number of measurements, including PT, SS, TL, TK, T9SPi, T1SPi, and SVA were inaccurately simulated. …”
Publicado 2017
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1749“…The potential for synergy was assessed by 24 hours time-kills (TK). Synergy was defined as >2 log(10) CFU/mL difference between combination and the most active single agent at 24 hours. …”
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1750por Cryer, Matthew, Lane, Kyle, Greer, Mary, Cates, Rex, Burt, Scott, Andrus, Merritt, Zou, Jiping, Rogers, Paul, Hansen, Marc D. H., Burgado, Jillybeth, Satheshkumar, Panayampalli Subbian, Day, Craig W., Smee, Donald F., Johnson, F. Brent“…Finally, KPB-100 inhibited HHV-2 TK- at an IC(50) value of 4.5 μg/mL in CPE inhibition assay and HHV-1 at an IC(90) of 3.0 μg/mL in VYR assay. …”
Publicado 2017
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1751por Salim, Muhammad Asad, Ranjitkar, Sailesh, Hart, Robbie, Khan, Tika, Ali, Sajid, Kiran, Chandni, Parveen, Asma, Batool, Zahra, Bano, Shanila, Xu, Jianchu“…MATERIALS AND METHODS: The study incorporated over 300 local community members (70% men and 30% women) in focused group discussions, semi-structured interviews, and homework assignments for 8th to 12th grade students to document traditional knowledge (TK) in six districts in Northeast Pakistan. We calculated various indices such as informant consensus factor, use value, relative frequency of citation, and CoKriging. …”
Publicado 2019
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1752por Manabe, Nodoka, Covaro, Augusto, Bobinski, Lukas, Shimizu, Takachika, Olerud, Claes, Robinson, Yohan“…There was a statistically significant difference observed in the T1–12, T5–12, and X-angles (p =0.004, 0.001, and <0.001, respectively). TK was greater in the ankylosed joint group than in the mobile joint group. …”
Publicado 2019
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1753por Pütter, Katharina M., van Deenen, Nicole, Müller, Boje, Fuchs, Lea, Vorwerk, Kirsten, Unland, Kristina, Bröker, Jan Niklas, Scherer, Emely, Huber, Claudia, Eisenreich, Wolfgang, Prüfer, Dirk, Schulze Gronover, Christian“…Furthermore, we isolated six different oxidosqualene cyclases (OSCs) and two P450 enzymes, and we functionally characterized TkOSC1 and CYP716A263 in Nicotiana benthamiana and Saccharomyces cerevisiae in detail. …”
Publicado 2019
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1754“…Sex, age, smoking status (yes or no), occupation (heavy or light labor), body mass index (BMI), bone mineral density (BMD) and radiographic parameters including the lumbar lordosis (LL), pelvic incidence (PI), pelvic tilt (PT), sacral slope (SS), thoracic kyphosis (TK), coronal vertical axis, and sagittal vertical axis (SVA) are all evaluated as potential risk factors. …”
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1755por Valverde, Jósé R., Gullón, Sonia, García-Herrero, Clara A., Campoy, Iván, Mellado, Rafael P.“…When applied to Sec- or Tat-dependent secretion of overproduced proteins in S. lividans, Adaptive DFBA can overcome the limitations of traditional DFBA to reproduce experimental data on plasmid-free, plasmid bearing and secretory protein overproducing S. lividans TK24, and can yield useful insights on the behaviour of systems with limited experimental knowledge such as agarase or amylase overproduction in S. lividans TK21. …”
Publicado 2019
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1756“…DCE‐MRI data were analyzed using five different single‐ or dual‐input tracer kinetic models: Tofts‐Kety (TK), extended TK (ETK), two compartment exchange (2CX), adiabatic approximation to the tissue homogeneity (AATH) and distributed parameter (DP) models. …”
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1757“…In this study, the varieties obtained through preliminary screening (i.e., TK14, HC56, TT30, TNG70, and TK8) exhibited outstanding thermotolerance. …”
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1758por Arise, Kiran K., Kumar, Prerna, Garg, Renu, Samivel, Ramachandran, Zhao, Hanqing, Pandya, Krishna, Nguyen, Christian, Lindsey, Sarah, Pandey, Kailash N.“…The repressive effect of ANG II on Npr1 transcription and receptor signaling seems to be transduced by TK and PI-3K pathways and modulated by CREB, HSF-4a, HDACs, and modified histones. …”
Publicado 2020
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1759“…In colorectal tumor models, mice treated with vaccinia VG9-TK(−) showed better tumor remission ability and prolonged survival. …”
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1760por Zhao, Yanhong, Teng, Binhong, Sun, Xun, Dong, Yunsheng, Wang, Shufang, Hu, Yongcheng, Wang, Zheng, Ma, Xinlong, Yang, Qiang“…HUCMSC were divided into four groups: control group, KGN group, TGF‐β3 group, and TK group (with TGF‐β3 and KGN added into the medium simultaneously). …”
Publicado 2020
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